TIGER

Journal Articles: 45 results
Molecules and Medicine (E. J. Corey, Barbara Czakó, and László Kürti)  Robert E. Buntrock
Looking for a book on common drugs and pharmaceuticals? On diseases and medical conditions? On pharmacology? In addition, do you need some background in chemistry to handle all of this information? If you want all of this, and in addition want it under one cover, then this is the book for you.
Buntrock, Robert E. J. Chem. Educ. 2008, 85, 1495.
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Molecular Properties / Structure |
Proteins / Peptides |
Synthesis |
Toxicology
Illustrating the Concepts of Isotopes and Mass Spectrometry in Introductory Courses: A MALDI-TOF Mass Spectrometry Laboratory Experiment  Nancy Carter Dopke and Timothy Neal Lovett
This article describes a matrix-assisted laser desorption/ionization (MALDI) mass spectrometry experiment in which students prepare peptide samples for mass analysis and then collect and analyze mass spectral data. The lab provides hands-on experience with research instrumentation and reinforces the concepts of isotopes, molecular masses, and molecular formulas.
Dopke, Nancy Carter; Lovett, Timothy Neal. J. Chem. Educ. 2007, 84, 1968.
Isotopes |
Mass Spectrometry |
Proteins / Peptides
A New Colorimetric Assay of Tabletop Sweeteners Using a Modified Biuret Reagent  Christopher J. Fenk, Nathan Kaufman, and Donald G. Gerbig, Jr.
Presents a new, fast and effective colorimetric analysis of aspartame that incorporates a less caustic biuret reagent and visible spectroscopic analysis for selective detection in aqueous solutions using readily available instrumentation.
Fenk, Christopher J.; Kaufman, Nathan; Gerbig, Donald G., Jr. J. Chem. Educ. 2007, 84, 1676.
Consumer Chemistry |
Coordination Compounds |
Crystal Field / Ligand Field Theory |
Food Science |
Qualitative Analysis |
Quantitative Analysis |
UV-Vis Spectroscopy |
Amino Acids
The A1c Blood Test: An Illustration of Principles from General and Organic Chemistry  Robert C. Kerber
The glycated hemoglobin blood test is a key measure of the effectiveness of glucose control in diabetics. The chemistry of glucose in the bloodstream, which underlies the test and its impact, provides an illustration of the importance of chemical equilibrium and kinetics to a major health problem.
Kerber, Robert C. . J. Chem. Educ. 2007, 84, 1541.
Applications of Chemistry |
Bioinorganic Chemistry |
Carbohydrates |
Mechanisms of Reactions |
Proteins / Peptides |
Bioorganic Chemistry
Nature's Way To Make the Lantibiotics  Heather A. Relyea and Wilfred A. van der Donk
This article focuses on one class of antimicrobial compounds, the lantibiotics, and discusses their biosynthetic pathways as well as their molecular mode of action. In the course of the review, the meaning of the terms regio-, chemo-, and stereoselectivity are discussed.
Relyea, Heather A.; van der Donk, Wilfred A. J. Chem. Educ. 2006, 83, 1769.
Applications of Chemistry |
Bioorganic Chemistry |
Biotechnology |
Biosynthesis |
Catalysis |
Drugs / Pharmaceuticals |
Proteins / Peptides
Using Physical Models of Biomolecular Structures To Teach Concepts of Biochemical Structure and Structure Depiction in the Introductory Chemistry Laboratory  Gordon A. Bain, John Yi, Mithra Beikmohamadi, Timothy M. Herman, and Michael A. Patrick
Custom-made physical models of alpha-helices and beta-sheets, the zinc finger moiety, beta-globin, and green fluorescent protein are used to introduce students in first-year chemistry to the primary, secondary, and tertiary structure of proteins.
Bain, Gordon A.; Yi, John; Beikmohamadi, Mithra; Herman, Timothy M.; Patrick, Michael A. J. Chem. Educ. 2006, 83, 1322.
Amino Acids |
Proteins / Peptides |
Molecular Modeling |
Molecular Properties / Structure |
Nucleic Acids / DNA / RNA
Amino Acids  William F. Coleman
The Featured Molecules this month are the 20 standard alpha-amino acids found in proteins. The molecules are presented in two formats, the neutral form and the ionized form found in solution at physiologic pH.
Coleman, William F. J. Chem. Educ. 2006, 83, 1103.
Amino Acids |
Proteins / Peptides |
Molecular Properties / Structure |
Molecular Modeling |
Molecular Mechanics / Dynamics
Amino Acid Complementarity: A Biochemical Exemplar of Stoichiometry for General and Health Sciences Chemistry  Ed Vitz
Calculations demonstrating amino acid complementarity are presented as an interesting application of stoichiometry. Food proteins are said to have complementary amino acids when the proteins combine to provide amino acids in the proper stoichiometric ratios to synthesize human protein. Implications for vegetarian diet, efficiency of food production, and diet adaptations in various cultures are explored briefly.
Vitz, Ed. J. Chem. Educ. 2005, 82, 1013.
Amino Acids |
Proteins / Peptides |
Stoichiometry |
Food Science
A Supramolecular Approach to Medicinal Chemistry: Medicine Beyond the Molecule  David K. Smith
This article emphasizes a conceptual view of medicinal chemistry, which has important implications for the future, as the supramolecular approach to medicinal-chemistry products outlined here is rapidly allowing nanotechnology to converge with medicine. In particular, this article discusses recent developments including the rational design of drugs such as Relenza and Tamiflu, the mode of action of vancomycin, and the mechanism by which bacteria develop resistance, drug delivery using cyclodextrins, and the importance of supramolecular chemistry in understanding protein aggregation diseases such as Alzheimer's and CreutzfieldJacob.
Smith, David K. J. Chem. Educ. 2005, 82, 393.
Drugs / Pharmaceuticals |
Noncovalent Interactions |
Medicinal Chemistry |
Nanotechnology |
Proteins / Peptides
A "Polypeptide Demonstrator"  Addison Ault
I have used a telephone Handset Coil Cord as a simple and convenient model for the structure of a polypeptide.
Ault, Addison. J. Chem. Educ. 2004, 81, 196.
Proteins / Peptides |
Molecular Modeling |
Molecular Properties / Structure
Mass Spectra  JCE Editorial Staff
Activity in which students solve puzzles analogous to finding the amino acid sequence of a peptide using mass spectrometry.
JCE Editorial Staff. J. Chem. Educ. 2003, 80, 176A.
Amino Acids |
Mass Spectrometry |
Proteins / Peptides
Some Like It Cold: A Computer-Based Laboratory Introduction to Sequence and Tertiary Structure Comparison of Cold-Adapted Lactate Dehydrogenases Using Bioinformatics Tools  M. Sue Lowery and Leigh A. Plesniak
Students download sequences and structures from appropriate databases, create sequence alignments, and carry out molecular modeling exercises, and then form hypotheses about the mechanism of biochemical adaptation for function and stability. This laboratory is appropriate for biochemistry and molecular biology laboratory courses, special topics, and advanced biochemistry lecture courses, and can be adapted for honors high school programs.
Lowery, M. Sue; Plesniak, Leigh A. J. Chem. Educ. 2003, 80, 1300.
Enzymes |
Molecular Modeling |
Proteins / Peptides |
Molecular Properties / Structure
Simple Recipes for Prebiotic Soup: A High School or Undergraduate Chemistry Laboratory  Marisol Martinez-Meeler, Nika Aljinovic, and Dorothy Swain
Replicating Stanley Miller's prebiotic soup experiment for introductory chemistry; includes experimental apparatus and analysis of the products.
Martinez-Meeler, Marisol; Aljinovic, Nika; Swain, Dorothy. J. Chem. Educ. 2003, 80, 665.
Amino Acids |
Aqueous Solution Chemistry |
Chromatography |
Electrochemistry |
Proteins / Peptides |
Synthesis |
Applications of Chemistry
Introducing Freshmen Students to the Practice of Solid-Phase Synthesis  Alpay Taralp, Can Hulusi Türkseven, Atilla Özgür Çakmak, and Ömer Çengel
Procedure to introduce freshmen to the principles and practice of solid-phase (peptide) synthesis.
Taralp, Alpay; Türkseven, Can Hulusi; Çakmak, Atilla Özgür; Çengel, Ömer. J. Chem. Educ. 2002, 79, 87.
Biotechnology |
Enzymes |
Synthesis |
Proteins / Peptides |
Undergraduate Research
Blood-Chemistry Tutorials: Teaching Biological Applications of General Chemistry Material  Rachel E. Casiday, Dewey Holten, Richard Krathen, and Regina F. Frey
Four, Web-based tutorials that deal with chemical processes in the blood and provide an integrated biological context for a variety of chemical concepts.
Casiday, Rachel E.; Holten, Dewey; Krathen, Richard; Frey, Regina F. J. Chem. Educ. 2001, 78, 1210.
Applications of Chemistry |
Medicinal Chemistry |
Proteins / Peptides |
Acids / Bases |
Equilibrium |
Molecular Properties / Structure
Protein Structure Wordsearch  Terry L. Helser
Puzzle with 37 names, terms, prefixes, and acronyms that describe protein structure.
Helser, Terry L. J. Chem. Educ. 2001, 78, 474.
Proteins / Peptides |
Nomenclature / Units / Symbols |
Molecular Properties / Structure
The Chemical Adventures of Sherlock Holmes: The Shroud of Spartacus  Thomas G. Waddell and Thomas R. Rybolt
A chemical mystery featuring Sherlock Holmes and Dr. Watson.
Waddell, Thomas G.; Rybolt, Thomas R. J. Chem. Educ. 2001, 78, 470.
Enrichment / Review Materials |
Forensic Chemistry |
Proteins / Peptides |
Quantitative Analysis
A Simple Protein Purification and Folding Experiment for General Chemistry Laboratory  Robert Bowen, Richard Hartung, and Yvonne M. Gindt
A simple procedure for the crude purification of a chromoprotein suitable for a general chemistry laboratory. The protein, phycocyanin, is easy to purify and very stable. It contains a chromophore that can serve to report the integrity of the protein structure: the chromoprotein is dark blue when the protein is folded in its native conformation, and it turns a very pale blue when the protein is unfolded or denatured.
Bowen, Robert ; Hartung, Richard; Gindt, Yvonne M. J. Chem. Educ. 2000, 77, 1456.
Noncovalent Interactions |
Photochemistry |
Proteins / Peptides |
UV-Vis Spectroscopy
Soup or Salad? Investigating the Action of Enzymes in Fruit on Gelatin  Erica Jacobsen
Some fruits contain proteases, a group of enzymes that catalyze the cleavage of peptide linkages in proteins. This can have an undesired effect in a gelatin salad containing fruit, because proteases in the fruit can cleave the proteins that make up the structure of gelatin so that it will not set.
Jacobsen, Erica. J. Chem. Educ. 1999, 76, 624A.
Enzymes |
Proteins / Peptides
Amino Acid Wordsearch  Terry L. Helser
This is a short puzzle with all 20 genetically encoded amino acids embedded in the matrix. The unused letters form a sentence describing them.
Helser, Terry L. J. Chem. Educ. 1999, 76, 494.
Amino Acids
Analysis of Iron in Ferritin, the Iron-Storage Protein: A General Chemistry Experiment  Maureen J. Donlin, Regina F. Frey, Christopher Putnam, Jody Proctor, and James K. Bashkin
The chemical properties of the iron-storage protein ferritin will be examined in this experiment by quantitating the average amount of iron in a ferritin sample, and observing the kinetics of iron release from the protein core under reducing conditions. Students learn and apply the principles of absorption spectroscopy, redox reactions, and metal chelation to study ferritin.
Maureen J. Donlin, Regina F. Frey, Christopher Putnam, Jody Proctor, and James K. Bashkin. J. Chem. Educ. 1998, 75, 437.
Oxidation / Reduction |
UV-Vis Spectroscopy |
Proteins / Peptides
Showing Food Foams Properties with Common Dairy Foods  Carlos Bravo-Diaz and Elisa Gonzalez-Romero
Some easy to carry, inexpensive and safe experiments developed using familiar kitchen materials related with egg foams. Eggs's properties are not only limited to prepare excellent and delicious emulsions like mayonnaise but also makes excellent foams, increasing their volume significantly in two primary ways.
Bravo-Diaz, Carlos; Gonzalez-Romero, Elisa. J. Chem. Educ. 1997, 74, 1133.
Learning Theories |
Food Science |
Proteins / Peptides |
Applications of Chemistry
Use of Tangle Links To Show Globular Protein Structure  Marino, Francis
Using Tangle Links (a child's toy) to model the primary, secondary, tertiary, and quaternary structure of proteins.
Marino, Francis J. Chem. Educ. 1994, 71, 741.
Proteins / Peptides |
Molecular Modeling
An Attack on the AIDS Virus: Inhibition of the HIV-1 Protease. New Drug Development Based on the Structure and Activity of the Protease and its Role in the Replication and Maturation of the Virus  Volker, Eugene J.
Article shows how research into the biochemistry of HIV may lead to a method for controlling its growth and maturation. This research illustrates some basic enzyme chemistry and holds student appeal due to the tie into current affairs.
Volker, Eugene J. J. Chem. Educ. 1993, 70, 3.
Bioorganic Chemistry |
Proteins / Peptides |
Medicinal Chemistry |
Molecular Biology
Biochemistry laboratory for the freshman chemistry curriculum  Falk, Peter M.
Intended to introduce students to two important biochemical principles: the study of biomolecules and metabolism.
Falk, Peter M. J. Chem. Educ. 1989, 66, 944.
Metabolism |
Carbohydrates |
Lipids |
Proteins / Peptides |
Plant Chemistry
Lecture demonstrations for organic/ biochemistry allied health courses  Deavor, James P.
Simple demonstrations on enantiomeric pairs and protein structure.
Deavor, James P. J. Chem. Educ. 1988, 65, 622.
Enantiomers |
Chirality / Optical Activity |
Proteins / Peptides |
Nonmajor Courses |
Amino Acids
Analysis of aspartame and its hydrolysis products by thin-layer chromatography  Conklin, Alfred R.
Separating and identifying the amino acids found in aspartame.
Conklin, Alfred R. J. Chem. Educ. 1987, 64, 1065.
Thin Layer Chromatography |
Amino Acids |
Food Science |
Separation Science |
Qualitative Analysis
Chemistry of polymers, proteins, and nucleic acids: A short course on macromolecules for secondary schools  Lulav, Ilan; Samuel, David
Topics considered in a macromolecular chemistry unit for advanced high school chemistry students.
Lulav, Ilan; Samuel, David J. Chem. Educ. 1985, 62, 1075.
Polymerization |
Proteins / Peptides
The catalytic function of enzymes  Splittgerber, Allan G.
Review of the structure, function, and factors that influence the action of enzymes.
Splittgerber, Allan G. J. Chem. Educ. 1985, 62, 1008.
Catalysis |
Enzymes |
Mechanisms of Reactions |
Proteins / Peptides |
Molecular Properties / Structure
Perspectives in biochemistry: Methods for DNA sequencing  Wood, Anne T.
Describes how DNA is sequenced.
Wood, Anne T. J. Chem. Educ. 1984, 61, 886.
Proteins / Peptides |
Biotechnology |
Electrophoresis
The chemical composition of the cell  Holum, John R.
A broad outline of the chemical substances that occur in most cells.
Holum, John R. J. Chem. Educ. 1984, 61, 877.
Biological Cells |
Lipids |
Carbohydrates |
Proteins / Peptides
Protein denaturation: A physical chemistry project lab  Pickering, Miles; Crabtree, Robert H.
This experiment links physical chemistry with biology and can be done with in advanced freshman course.
Pickering, Miles; Crabtree, Robert H. J. Chem. Educ. 1981, 58, 513.
Proteins / Peptides |
Biophysical Chemistry |
Molecular Properties / Structure
Molecular membrane model  Huebner, J. S.
Making a model of a lipid bilayer using polystyrene balls and pipe cleaners.
Huebner, J. S. J. Chem. Educ. 1977, 54, 171.
Membranes |
Lipids |
Molecular Modeling |
Proteins / Peptides |
Dyes / Pigments
Amino acid sequence diversity in proteins  Blackman, David
The number of unique proteins that can be generated from a small number of amino acids is truly enormous.
Blackman, David J. Chem. Educ. 1977, 54, 170.
Proteins / Peptides |
Amino Acids
Non-covalent interactions: Key to biological flexibility and specificity  Frieden, Earl
Summarizes the types of non-covalent interactions found among biomolecules and how they facilitate the function of antibodies, hormones, and hemoglobin.
Frieden, Earl J. Chem. Educ. 1975, 52, 754.
Noncovalent Interactions |
Hydrogen Bonding |
Water / Water Chemistry |
Proteins / Peptides |
Amino Acids |
Molecular Properties / Structure |
Hormones
Sulfur compounds. Pollution, health effects, and biological function  Leh, F.; Chan, K. M.
Reviews the role of sulfur and its compounds in pollution and adverse health effects as well as biological functions.
Leh, F.; Chan, K. M. J. Chem. Educ. 1973, 50, 246.
Nonmetals |
Proteins / Peptides
Disposable macromolecular model "kits"  Nicholson, Isadore
A brief note suggesting the use of colored pipe cleaners for the construction of three dimensional models of polymers, particularly enzymes and other proteins.
Nicholson, Isadore J. Chem. Educ. 1969, 46, 671.
Molecular Modeling |
Enzymes |
Proteins / Peptides
Disc electrophoresis  Brewer, John M.; Ashworth, Raymond B.
Describes the procedures involved in separating proteins or nucleic acids through disc electrophoresis.
Brewer, John M.; Ashworth, Raymond B. J. Chem. Educ. 1969, 46, 41.
Electrochemistry |
Electrophoresis |
Proteins / Peptides |
Separation Science
VI - Biochemistry in the introductory college chemistry course  Sturtevant, Julian M.
To whatever extent one wishes in the introductory chemistry course to stimulate students' interest in the subject, it seems important to include illustrations of the role chemical progress plays in biology.
Sturtevant, Julian M. J. Chem. Educ. 1967, 44, 184.
Enzymes |
Proteins / Peptides |
Bioenergetics
Ribonucleic acid: The simplest information-transmitting molecule  Fraenkel-Conrat, H.
Examines the chemical structure of nucleic acids, chemical modification of RNA and mutagenesis, role of RNA in protein structure, the mechanism of information transfer from RNA to protein, and mutants and coding.
Fraenkel-Conrat, H. J. Chem. Educ. 1963, 40, 216.
Proteins / Peptides
Structural variety of natural products  Roderick, William R.
Classes of natural products examined includes alkynes; quinones; benzpyrones; small and large rings; sulfur, nitrogen, and halogen-containing compounds; and new amino acids.
Roderick, William R. J. Chem. Educ. 1962, 39, 2.
Natural Products |
Amino Acids |
Alkynes |
Aromatic Compounds
Student experiment with filter paper electrophoresis  Garvin, James E.
The effect of electrical charge in determining some of the properties of amino acids and proteins can be simply and convincingly demonstrated to the student by means of filter paper electrophoresis.
Garvin, James E. J. Chem. Educ. 1961, 38, 36.
Separation Science |
Electrophoresis |
Amino Acids |
Proteins / Peptides |
Electrochemistry
The geometry of giant molecules  Price, Charles C.
The author examines a variety of specific examples of natural and synthetic polymer molecules and describes how their geometric molecular arrangements influence their properties.
Price, Charles C. J. Chem. Educ. 1959, 36, 160.
Molecular Properties / Structure |
Proteins / Peptides |
Carbohydrates
Schematic models of biochemical polymers  Blackwell, R. Quentin
Demonstrates the use of plastic necklace beads to represent polysaccharides, peptides and proteins, and nucleotides.
Blackwell, R. Quentin J. Chem. Educ. 1957, 34, 500.
Molecular Modeling |
Molecular Properties / Structure |
Proteins / Peptides |
Carbohydrates
Potentialities of protein isomerism  Asimov, Isaac
The permutations generated by structural isomerism in proteins could be demonstrated more convincingly and realistically if the amino acid compositions of actual proteins were taken into consideration.
Asimov, Isaac J. Chem. Educ. 1954, 31, 125.
Proteins / Peptides |
Molecular Properties / Structure |
Amino Acids |
Constitutional Isomers