TIGER

Journal Articles: 22 results
Helping Students Assess the Relative Importance of Different Intermolecular Interactions  Paul G. Jasien
A semi-quantitative model has been developed to estimate the relative effects of dispersion, dipoledipole interactions, and H-bonding on the normal boiling points for a series of simple, straight-chain organic compounds. Application of this model may be useful in addressing student misconceptions related to the additivity of intermolecular interactions.
Jasien, Paul G. J. Chem. Educ. 2008, 85, 1222.
Chemometrics |
Molecular Properties / Structure |
Noncovalent Interactions |
Physical Properties
Dancing Crystals: A Dramatic Illustration of Intermolecular Forces  Donald W. Mundell
Crystals of naphthalene form on the surface of an acetone solution and dance about in an animated fashion illustrating surface tension, crystallization, and intermolecular forces. Additional experiments reveal the properties of the solution and previous demonstrations of surface motion are explored.
Mundell, Donald W. J. Chem. Educ. 2007, 84, 1773.
Aromatic Compounds |
Liquids |
Molecular Mechanics / Dynamics |
Molecular Properties / Structure |
Physical Properties |
Surface Science |
Noncovalent Interactions
Molecular Handshake: Recognition through Weak Noncovalent Interactions  Parvathi S. Murthy
This article traces the development of our thinking about molecular recognition through noncovalent interactions, highlights their salient features, and suggests ways for comprehensive education on this important concept.
Murthy, Parvathi S. J. Chem. Educ. 2006, 83, 1010.
Applications of Chemistry |
Biosignaling |
Membranes |
Molecular Recognition |
Noncovalent Interactions |
Chromatography |
Molecular Properties / Structure |
Polymerization |
Reactions
Intermolecular and Intramolecular Forces: A General Chemistry Laboratory Comparison of Hydrogen Bonding in Maleic and Fumaric Acids  Frazier W. Nyasulu and John Macklin
This article presents a simple laboratory experiment that is designed to enhance students' understanding of inter- and intramolecular hydrogen bonding by demonstrating the comparative effect of these phenomena on some chemical and physical properties.
Nyasulu, Frazier W.; Macklin, John. J. Chem. Educ. 2006, 83, 770.
Acids / Bases |
Hydrogen Bonding |
Noncovalent Interactions |
Thermodynamics |
Titration / Volumetric Analysis
The Nature of Hydrogen Bonding  Emeric Schultz
Students use toy connecting blocks and Velcro to investigate weak intermolecular interactions, specifically hydrogen bonds.
Schultz, Emeric. J. Chem. Educ. 2005, 82, 400A.
Noncovalent Interactions |
Hydrogen Bonding |
Phases / Phase Transitions / Diagrams |
Water / Water Chemistry |
Covalent Bonding |
Molecular Modeling |
Molecular Properties / Structure
Simple Dynamic Models for Hydrogen Bonding Using Velcro-Polarized Molecular Models  Emeric Schultz
This article describes the use of models that dynamically illustrate the unique characteristics of weak intermolecular interactions, specifically hydrogen bonds. The models clearly demonstrate that H-bonds can break and reform while covalent bonds stay intact. The manner in which the models form and break H-bonds reflects the geometric and statistical manner in which H-bonding actually occurs and is not contrived. The use of these models addresses a significant area of student misconceptions. The construction of these molecular models is described.
Schultz, Emeric. J. Chem. Educ. 2005, 82, 401.
Molecular Properties / Structure |
Molecular Modeling |
Noncovalent Interactions |
Hydrogen Bonding |
Water / Water Chemistry |
Phases / Phase Transitions / Diagrams
A Supramolecular Approach to Medicinal Chemistry: Medicine Beyond the Molecule  David K. Smith
This article emphasizes a conceptual view of medicinal chemistry, which has important implications for the future, as the supramolecular approach to medicinal-chemistry products outlined here is rapidly allowing nanotechnology to converge with medicine. In particular, this article discusses recent developments including the rational design of drugs such as Relenza and Tamiflu, the mode of action of vancomycin, and the mechanism by which bacteria develop resistance, drug delivery using cyclodextrins, and the importance of supramolecular chemistry in understanding protein aggregation diseases such as Alzheimer's and CreutzfieldJacob.
Smith, David K. J. Chem. Educ. 2005, 82, 393.
Drugs / Pharmaceuticals |
Noncovalent Interactions |
Medicinal Chemistry |
Nanotechnology |
Proteins / Peptides
Intermolecular Forces as a Key to Understanding the Environmental Fate of Organic Xenobiotics  Ryan E. Casey and Faith A. Pittman
We have developed an environmental chemistry module that can be used in high schools or undergraduate nonscience courses to relate chemical structures and properties to the macroscopic behavior of environmentally relevant organic chemicals like pesticides, PCBs, and solvents. The module introduces the concepts of intermolecular forces, polarity, and partitioning to explain complex phenomena such as environmental transport and biomagnification of xenobiotics (human-made chemicals).
Casey, Ryan E.; Pittman, Faith A. J. Chem. Educ. 2005, 82, 260.
Nonmajor Courses |
Hydrogen Bonding |
Noncovalent Interactions
Purple or Colorless—Which Way Up? An Entertaining Solubility Demonstration  Trevor M. Kitson
Discrepant demonstration involving immiscible mixture of water colored with potassium permanganate and hexane.
Kitson, Trevor M. J. Chem. Educ. 2003, 80, 892.
Aqueous Solution Chemistry |
Solutions / Solvents |
UV-Vis Spectroscopy |
Noncovalent Interactions |
Molecular Properties / Structure |
Physical Properties
Laboratory Sequence in Computational Methods for Introductory Chemistry  Jason A. Cody and Dawn C. Wiser
Description of a four-week laboratory sequence that exposes students to instrumentation (FT-NMR, GC) and computational chemistry.
Cody, Jason A.; Wiser, Dawn C. J. Chem. Educ. 2003, 80, 793.
Chromatography |
Computational Chemistry |
Noncovalent Interactions |
MO Theory |
Molecular Modeling |
Molecular Mechanics / Dynamics |
Molecular Properties / Structure |
NMR Spectroscopy |
Gas Chromatography
Rubber Bands, Free Energy, and Le Châtelier's Principle  Warren Hirsch
Using a rubber band to illustrate Gibbs free energy, entropy, and enthalpy.
Hirsch, Warren. J. Chem. Educ. 2002, 79, 200A.
Noncovalent Interactions |
Thermodynamics |
Equilibrium
A Structure–Activity Investigation of Photosynthetic Electron Transport. An Interdisciplinary Experiment for the First-Year Laboratory  Kerry K. Karukstis, Gerald R. Van Hecke, Katherine A. Roth, and Matthew A. Burden
Investigation in which students measure the effect of several inhibitors (herbicides) on the electron transfer rate in chloroplasts and formulate a hypothesis between the inhibitor's activity and its structure as a means of using a physical technique to measure a chemical process in a biological system.
Karukstis, Kerry K.; Van Hecke, Gerald R.; Roth, Katherine A.; Burden, Matthew A. J. Chem. Educ. 2002, 79, 985.
Biophysical Chemistry |
Electrochemistry |
Noncovalent Interactions |
Molecular Properties / Structure |
UV-Vis Spectroscopy |
Aromatic Compounds |
Plant Chemistry
Boiling Points of the Family of Small Molecules CHwFxClyBrz: How Are They Related to Molecular Mass?  Michael Laing
Investigating the role of molecular mass in determining boiling points of small molecules.
Laing, Michael. J. Chem. Educ. 2001, 78, 1544.
Atomic Properties / Structure |
Noncovalent Interactions |
Liquids |
Molecular Properties / Structure |
Physical Properties
A Simple Protein Purification and Folding Experiment for General Chemistry Laboratory  Robert Bowen, Richard Hartung, and Yvonne M. Gindt
A simple procedure for the crude purification of a chromoprotein suitable for a general chemistry laboratory. The protein, phycocyanin, is easy to purify and very stable. It contains a chromophore that can serve to report the integrity of the protein structure: the chromoprotein is dark blue when the protein is folded in its native conformation, and it turns a very pale blue when the protein is unfolded or denatured.
Bowen, Robert ; Hartung, Richard; Gindt, Yvonne M. J. Chem. Educ. 2000, 77, 1456.
Noncovalent Interactions |
Photochemistry |
Proteins / Peptides |
UV-Vis Spectroscopy
The Solubility of Ionic Solids and Molecular Liquids  C. Baer and Sheila M. Adamus
The solubilities of three ionic salts (NaCl, PbCl2, and KAl(SO4)2.12H2O) in water are measured at four temperatures. The concept of recrystallization is introduced as students cool a high-temperature solution and observe crystal formation. Spreadsheet calculations are performed with the group data, which are then graphed, and students observe the wide variance in solubility behavior for the three salts.
Baer, Carl; Adamus, Sheila M. J. Chem. Educ. 1999, 76, 1540.
Noncovalent Interactions |
Laboratory Computing / Interfacing |
Liquids |
Molecular Properties / Structure |
Solutions / Solvents
London Dispersion Forces and "The Wave"  C. Jayne Wilcox
An analogy is presented likening London dispersion forces to "The Wave", a popular ritual performed by fans attending sports events in large stadia. Similarities between people in the stands and electrons in atoms are emphasized.
Wilcox, C. Jayne. J. Chem. Educ. 1998, 75, 1301.
Noncovalent Interactions
Intermolecular Forces in Introductory Chemistry Studied by Gas Chromatography, Computer Models, and Viscometry  Jonathan C. Wedvik, Charity McManaman, Janet S. Anderson, and Mary K. Carroll
Students performing gas chromatographic (GC) analyses of mixtures of n-alkanes and samples that simulate crime scene evidence discover that liquid mixtures can be separated rapidly into their components based upon intermolecular forces. Each group of students is given a liquid sample that simulates one collected at an arson scene, and the group is required to determine the identity of the accelerant. Students also examine computer models to better visualize how molecular structure affects intermolecular forces: London forces, dipole-dipole interactions, and hydrogen bonding.
Wedvik, Jonathan C.; McManaman, Charity; Anderson, Janet S.; Carroll, Mary K. J. Chem. Educ. 1998, 75, 885.
Theoretical Chemistry |
Chromatography |
Noncovalent Interactions |
Gas Chromatography |
Molecular Modeling |
Forensic Chemistry |
Alkanes / Cycloalkanes |
Hydrogen Bonding |
Molecular Properties / Structure
Why Do Alcoholic Beverages Have "Legs"?  Todd P. Silverstein
After a sip of wine, "legs" of liquid typically run up and down the inside of the glass for many minutes. This phenomenon stems from the dipole-dipole intermolecular forces that are so important in understanding the physical behavior of aqueous solutions.
Silverstein, Todd P. J. Chem. Educ. 1998, 75, 723.
Noncovalent Interactions |
Aqueous Solution Chemistry |
Learning Theories |
Alcohols |
Hydrogen Bonding
A Simple Demonstration of How Intermolecular Forces Make DNA Helical  Michael F. Bruist
The usage of stacked identical boxes can be used to demonstrate the helical shape of DNA by the effect of intermolecular forces.
Bruist, Michael F. J. Chem. Educ. 1998, 75, 53.
Molecular Properties / Structure |
Hydrogen Bonding |
Noncovalent Interactions |
Molecular Modeling
An Intermolecular Forces Study Using IBM PSL  Eckberg, Christine; Zimmer, John; Reeves, James; Ward, Charles
Procedure to investigate evaporative cooling for a family of straight chain alcohols.
Eckberg, Christine; Zimmer, John; Reeves, James; Ward, Charles J. Chem. Educ. 1994, 71, A225.
Physical Properties |
Noncovalent Interactions |
Alcohols
Experiments for Modern Introductory Chemistry: Intermolecular Forces and Raoult's Law  Berka, Ladislav H.; Kildahl, Nicholas
Procedure that illustrates the liquid-vapor phase equilibrium of ideal and nonideal solutions.
Berka, Ladislav H.; Kildahl, Nicholas J. Chem. Educ. 1994, 71, 613.
Noncovalent Interactions |
Gas Chromatography |
Gases |
Liquids |
Equilibrium |
Solutions / Solvents
Which will evaporate first?  Stenmark, Allan
The evaporation rate of various short-chain alcohols and diethyl ether are compared.
Stenmark, Allan J. Chem. Educ. 1987, 64, 351.
Physical Properties |
Noncovalent Interactions |
Hydrogen Bonding |
Molecular Properties / Structure |
Alcohols |
Ethers