31.8. How Does the Human Immunodeficiency Virus Cause AIDS?, 829
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Protein Reactions Curdling milk, decomposition of hydrogen peroxide by catalase, glucose oxidase activity, hydrolyzing of sucrose with invertase, and using an enzyme to halt the Briggs-Rauscher reaction are demonstrated. Inhibiting the enzyme HIV-1 protease may slow the spread of AIDS.
Proteins / Peptides
HIV-1 Protease: An Enzyme at Work This is "HIV-1 Protease: An Enzyme at Work", from a video tape published by the Journal of Chemical Education - Software as Special Issue 13
Applications of Chemistry |
Enzymes |
Proteins / Peptides |
Medicinal Chemistry
Nature of Proteins Effect of pH on solubility, denaturing proteins, hydrolysis in strong base, binding to coomassie blue, dying wool and cotton, gel filtration column, reaction of ninhydrin with amino acids and precipitating protein with ammonium sulfate are demonstrated.
An NMR-Smell Module for the First-Semester General Chemistry LaboratoryErich S. Uffelman, Elizabeth H. Cox, J. Brown Goehring, Tyler S. Lorig, and C. Michele Davis The series of experiments involves an exploration of organic stereochemistry via hands-on model building, several chemosensory smell tests, and hands-on use of 13C NMR, thus serving as a powerful interdisciplinary lab involving chemistry, physics, and neuroscience. Similarities and differences between NMR and MRI methods are emphasized. Uffelman, Erich S.; Cox, Elizabeth H.; Goehring, J. Brown; Lorig, Tyler S.; Davis, C. Michele. J. Chem. Educ.2003, 80, 1368.
NMR Spectroscopy |
Stereochemistry |
Molecular Modeling |
Medicinal Chemistry
Drugs and the Human Body: With Implications for Society, 6th Edition by Ken LiskaDavid J. A. Schedler Facts about drug sources, history, action in the body, side effects, interactions, tolerance, abuse potential, dosage, dependency, delivery systems, and alternatives to drug use. Schedler, David J. A. J. Chem. Educ.2002, 79, 805.
Nitric Oxide-Releasing CompoundsWilliam F. Coleman, Randall J. Wildman The five WebWare Molecules for December derive from the article Nitrogen-Based Diazeniumdiolates: Versatile Nitric Oxide-Releasing Compounds for Biomedical Research and Potential Clinical Applications by Joseph E. Saavedra and Larry K. Keefer.
Medicinal Chemistry
Prophine and ProtoporphyrinWilliam F. Coleman, Randall J. Wildman The WebWare molecules this month are from the article "Photochemotherapy: Light-Dependent Therapies in Medicine" by Edward P. Zovinka and Danielle R. Suneri. The first is a simple porphine, illustrating the ubiquitous four-nitrogen macrocycle, while the second is the protoporphyrin found in heme systems.
Medicinal Chemistry |
Photochemistry
Elements That Disintegrate Volume 03, issue 32 of a series of leaflets covering subjects of interest to students of elementary chemistry distributed in 1929 - 1932.