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HIV-1 Protease: An Enzyme at Work This is "HIV-1 Protease: An Enzyme at Work", from a video tape published by the Journal of Chemical Education - Software as Special Issue 13
Applications of Chemistry |
Enzymes |
Proteins / Peptides |
Medicinal Chemistry
Nature of Proteins Effect of pH on solubility, denaturing proteins, hydrolysis in strong base, binding to coomassie blue, dying wool and cotton, gel filtration column, reaction of ninhydrin with amino acids and precipitating protein with ammonium sulfate are demonstrated.
Proteins / Peptides
Protein Reactions Curdling milk, decomposition of hydrogen peroxide by catalase, glucose oxidase activity, hydrolyzing of sucrose with invertase, and using an enzyme to halt the Briggs-Rauscher reaction are demonstrated. Inhibiting the enzyme HIV-1 protease may slow the spread of AIDS.
Gifts from Mother Earth—The Good, the Bad, and the UglySabine Heinhorst and Gordon C. Cannon Recent articles from the journal Nature that deal with good, bad, and ugly gifts from Mother Earth are described. Heinhorst, Sabine; Cannon, Gordon C. J. Chem. Educ.2006, 83, 196.
Biosynthesis |
Biotechnology |
Natural Products |
Nutrition |
Plant Chemistry |
Polymerization |
Proteins / Peptides
Based on a True Story: Using Movies as Source Material for General Chemistry ReportsMark A. Griep and Marjorie L. Mikasen Presents a list of one dozen, highly rated movies in which the focus is either a scientist's chemical research or the societal impact of some chemical compound. The method by which two of these movies were used as source material for a written report in a general chemistry course is described. Griep, Mark A.; Mikasen, Marjorie L. J. Chem. Educ.2005, 82, 1501.
Medicinal Chemistry |
Women in Chemistry |
Applications of Chemistry |
Drugs / Pharmaceuticals |
Industrial Chemistry |
Nonmajor Courses |
Nuclear / Radiochemistry
Experiments with AspirinLonda L. Borer and Edward Barry Experiments include (i) synthesis, purification, and characterization of aspirin by mp and TLC, (ii) percentage composition of a commercial aspirin tablet by titration, (iii) kinetics of the hydrolysis of aspirin to salicylic acid under various conditions, (iv) synthesis and characterization of copper(II) aspirinate and copper(II) salicylate, and (v) reaction of copper(II) aspirinate in aqueous solution. Borer, Londa L.; Barry, Edward. J. Chem. Educ.2000, 77, 354.
Collection of Chiral Drug, Pesticide, and Fragrance Molecular ModelsWilliam F. Coleman The article by Mannschreck, Kiessewetter, and von Angerer on the differential interactions between enantiomers and biological receptors (1) is the source for this month's Featured Molecules. Included in the molecule collection are all of the molecules described in the paper. In many instances we have included structures of multiple optical isomers of the same molecule so that students can not only see the forms that are active, but those that are less active, inactive, or act in an undesirable manner. These molecules will serve as good practice in determining optical configurations, and will also introduce additional forms of isomerism that students may be less familiar with than they are with R and S. Since multiple enantiomers and diastereomers are provided, students may use these molecules, together with an appropriate computational package, to verify that enantiomers have the same energy while diastereomers do not. The tuberculosis drug ethambutol provides an interesting case as both nitrogen atoms are also chiral as well as the two chiral carbon atoms. A calculation on a given structure will include the effect of that nitrogen chirality, although nitrogen inversion is expected to be quite rapid in this molecule. The conformations for the ethambutol molecules that are included here consider all four chiral atoms and are of the form (CNNC). A reasonable computational exercise would be to find the transition state for nitrogen inversion and the barrier height for that process. The supplemental material that is included with the featured article (1) includes a number of molecules that we will add to the collection as time permits. The result, including enantiomers and diastereomers, will be well over 200 additional molecules. A notice will appear in the JCE Featured Molecules column when this new set of molecules is available in JCE Online.
