27.4. Primary Structure of Polypeptides and Proteins
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Nature of Proteins Effect of pH on solubility, denaturing proteins, hydrolysis in strong base, binding to coomassie blue, dying wool and cotton, gel filtration column, reaction of ninhydrin with amino acids and precipitating protein with ammonium sulfate are demonstrated.
Proteins / Peptides
Protein Reactions Curdling milk, decomposition of hydrogen peroxide by catalase, glucose oxidase activity, hydrolyzing of sucrose with invertase, and using an enzyme to halt the Briggs-Rauscher reaction are demonstrated. Inhibiting the enzyme HIV-1 protease may slow the spread of AIDS.
Proteins / Peptides
Denaturation of Protein by Strong AcidJohn W. Moore, Jerrold J. Jacobsen, Gary Trammell, Kristin Johnson "Strong acid denatures egg white proteins.This video contains voiceover:""The tertiary structure of egg white proteins is held together by hydrogen bonding and hydrophobic interactions. Adding strong acid to the protein disrupts the intermolecular forces, and the tertiary structure is lost. The loss in protein structure is called denaturation. The proteins precipitate, forming a white solid."""
Molecules and Medicine (E. J. Corey, Barbara Czakó, and László Kürti)Robert E. Buntrock Looking for a book on common drugs and pharmaceuticals? On diseases and medical conditions? On pharmacology? In addition, do you need some background in chemistry to handle all of this information? If you want all of this, and in addition want it under one cover, then this is the book for you. Buntrock, Robert E. J. Chem. Educ.2008, 85, 1495.
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Molecular Properties / Structure |
Proteins / Peptides |
Synthesis |
Toxicology
OMLeT—An Alternative Approach to Learning Metabolism: Glycolysis and the TCA Cycle as an ExampleCharles M. Stevens, Dylan M. Silver, Brad Behm, Raymond J. Turner, and Michael G. Surette Using PHP Hypertext Preprocessor scripting, the dynamic OMLeT (Online Metabolism Learning Tool) Web site is geared towards different learning styles and allows the student to process metabolic pathways (glycolysis and TCA cycle) via a user-defined approach. Stevens, Charles M.; Silver, Dylan M.; Behm, Brad; Turner, Raymond J.; Surette, Michael G. J. Chem. Educ.2007, 84, 2024.
Bioenergetics |
Enzymes |
Learning Theories |
Metabolism |
Proteins / Peptides
The A1c Blood Test: An Illustration of Principles from General and Organic ChemistryRobert C. Kerber The glycated hemoglobin blood test is a key measure of the effectiveness of glucose control in diabetics. The chemistry of glucose in the bloodstream, which underlies the test and its impact, provides an illustration of the importance of chemical equilibrium and kinetics to a major health problem. Kerber, Robert C. . J. Chem. Educ.2007, 84, 1541.
Primary Protein StructureEd Vitz, John W. Moore A section of ChemPrime, the Chemical Educations Digital Library's free General Chemistry textbook.
Proteins / Peptides
Umami and ProteinsRobert Hetue A section of ChemPrime, the Chemical Educations Digital Library's free General Chemistry textbook.
Proteins / Peptides
ChemPaths 104 M Jan 31John W. Moore Today in Chem 104:
* Lecture: Biochemistry: Proteins
* Reading:
Kotz: Chemistry of Life (pp. 496-502);
Moore: Ch 3, Sec 11; Ch 12, Sec 7
* Biomolecules Tutorials
o Proteins 1 (including debriefing)
o Proteins 2 (including debriefing)
o Quiz due W Feb. 2, 11:55 PM)
* Homework #3 due by 11:55pm F Feb 4.
