TIGER

Other Resources: 12 results
Aromatic Hydrocarbons  Ed Vitz, John W. Moore
A section of ChemPrime, the Chemical Educations Digital Library's free General Chemistry textbook.
Aromatic Compounds
Conjugated Systems  Ed Vitz, John W. Moore
A section of ChemPrime, the Chemical Educations Digital Library's free General Chemistry textbook.
Aromatic Compounds
ChemPaths 104 W Feb 23  John W. Moore
Today in Chem 104: * Lecture: Mechanisms of Reactions * Reading: Kotz, Ch. 15, Sec. 5-6 Moore, Ch. 13, Sec. 6-76 * Homework #5 due by 11:55 pm F Feb 25 * Excel Assignment due in first discussion section this week * Quiz 4 in second discussion section this week
Mechanisms of Reactions
ChemPaths 104 F Feb 25  John W. Moore
Today in Chem 104: * Lecture: Problem-Solving Session * No assigned reading for today. * Homework #5 due by 11:55 pm Today! * Biomolecules Tutorial Enzymes (including Enzymes Quiz) is due Wed. Mar. 2, at 11:55 pm.
Mechanisms of Reactions
Reaction Mechanisms  Ed Vitz, John W. Moore
A section of ChemPrime, the Chemical Educations Digital Library's free General Chemistry textbook.
Mechanisms of Reactions
Mechanism-Based Kinetics Simulator  Robert M. Hanson
Simulate the kinetics of a reaction based on its mechanism using JavaScript. The idea is to write a mechanism and, based on that, follow the course of concentrations or rates of change in concentration of reactants, catalysts, intermediates, and products over time.
Kinetics |
Catalysis |
Mechanisms of Reactions
Coumarin, Naphthalene, and Additional Polycyclic Aromatic Hydrocarbons  William F. Coleman
The featured molecules this month are drawn from two papers. The first, "One-Pot Synthesis of 7-Hydroxy-3-carboxycoumarin in Water", is a Green Chemistry feature by Fringuelli, Piermatti, and Pizzo. The three-dimensional versions of the molecules in the synthesis of the coumarin derivative are directly tied to the reaction scheme included in the paper, opening the possibility of showing large numbers of complex synthetic pathways in this manner.The second paper is "Determining the Carbon-Carbon Distance in an Organic Molecule with a Ruler" by Simoni, Tubino, and Ricchi. This article describes an experiment to determine the size of a naphthalene molecule, using an extension of classic experiments for determining molecular size and Avogadro's number. While the structure of naphthalene will come as no surprise to most students, the molecule collection also includes additional polycyclic aromatic hydrocarbons (PAHs) that can be used to introduce students to the environmental and health issues related to these molecules.
Molecular Modeling |
Molecular Properties / Structure |
Aromatic Compounds
Percent Yield  Ed Vitz, John W. Moore
A section of ChemPrime, the Chemical Educations Digital Library's free General Chemistry textbook.
Synthesis
Molecular Models of Products and Reactants from Suzuki and Heck Syntheses  William F. Coleman
Our Featured Molecules this month come from the paper by Evangelos Aktoudianakis, Elton Chan, Amanda R. Edward, Isabel Jarosz, Vicki Lee, Leo Mui, Sonya S. Thatipamala, and Andrew P. Dicks (1), in which they describe the synthesis of 4-phenylphenol using an aqueous-based Suzuki reaction. The authors describe the various ways in which this reaction addresses concerns of green chemistry, and point out that their product bears structural similarity to two non-steroidal anti-inflammatory drugs (NSAIDs), felbinac and diflunisal. A number of molecules from this paper and its online supplemental material have been added to the Featured Molecules collection. Students will first notice that the aromatic rings in the molecules based on a biphenyl backbone are non-planar, as is the case in biphenyl. If they look carefully at diflunisal, they will notice that the carbon atoms are in a different chemical environment. One way in which to see the effect of these differing environments is to examine the effect of atom charge on the energies of the carbon 1s orbitals. Figure 1 shows this effect using charges and energies from an HF/631-G(d) calculation. A reasonable question to ask students would be to assign each of the data points to the appropriate carbon atom. As an extension of this exercise students could produce similar plots using different computational schemes. Are the results the same; are they parallel. This would be a useful problem when dealing with the tricky question of exactly what is meant by atom charge in electronic structure calculations. Students with more expertise in organic chemistry could explore extending the synthesis of 4-phenylphenol to produce more complex bi- and polyphenyl-based drugs. This may well be the first time that they have seen coupling reactions such as the Suzuki and Heck reactions. Students in introductory and non-science-major courses might well find the NSAIDs to be an interesting group of molecules, and could be asked to find information on the variety of molecules that display the anti-inflammatory properties associated with NSAIDs. Do they find structural similarities? Are there various classes of NSAIDs? Are they familiar with any of these molecules? Have they taken any NSAIDs? If so, for what reason? Is there any controversy about any of the NSAIDs? As with all of the molecules in the Featured Molecules collections, those added this month provide us with a number of ways of showing students the practical relevance of what they sometime see only as lines on a page. Molecules do matter.
Synthesis
Mechanisms That Interchange Axial and Equatorial Atoms in Fluxional Processes  Marion E. Cass, Henry S. Rzepa, King Kuok Hii
The Berry pseudorotation is a classical mechanism for interchanging axial and equatorial ligands in molecules with trigonal bipyramidal geometry. Teaching this mechanism presents particular pedagogic problems due to both its dynamic and three dimensional character. The approach taken here illustrates these processes using interactive animations embedded in a Web page and overcomes many limitations of a printed page.
Computational Chemistry |
Molecular Properties / Structure |
Nonmetals |
Enantiomers |
NMR Spectroscopy |
Mechanisms of Reactions |
Molecular Mechanics / Dynamics
Creative Chemistry  
Volume 04, issue 15 of a series of leaflets covering subjects of interest to students of elementary chemistry distributed in 1929 - 1932.
Applications of Chemistry |
Synthesis
Molecular Models of Plant Hormones  William F. Coleman
The paper "Synthesis of Plant Auxin Derivatives and Their Effects on Ceratopteris richardii" by Corey E. Stilts and Roxanne Fisher describing an experiment begun in the organic labs and completed in a biochemistry cell biology lab provides the featured molecules for this month. The molecules in Figure 1 of that paper have been added to the collection. There is nothing particularly surprising about their structures, but students might be interested in seeing whether they can determine any structure/regulating effect relationships as the number of synthesized auxin derivatives grows. Additionally, students with little or no biochemistry background might wish to explore other systems that act as growth regulating hormones in plants, as an introduction to the variety of molecular structures that can display such bioactivity. Such molecules range from the very simple, ethene, to the adenine-derived cytokinins (an example of which, zealtin, is shown here) and the brassinosteroids. Brassinolide, a commonly occurring brassin, is also shown. These latter two structures have also been added to the molecule collection. All of the structures have been optimized at the HF/6-31G(d) level.
Synthesis |
Biological Cells |
Hormones |
Bioorganic Chemistry