| Journal Articles: 20 results |
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The Iodochlorination of Styrene: An Experiment That Makes a Difference R. Gary Amiet and Sylvia Urban
This purpose of this laboratory exercise is to determine the various substitution and elimination products generated in the iodochlorination of styrene and their relative proportions through the application of mechanistic principles and a basic knowledge of GCMS and NMR.
Amiet, R. Gary; Urban, Sylvia. J. Chem. Educ. 2008, 85, 962.
Alkenes |
Constitutional Isomers |
Gas Chromatography |
Instrumental Methods |
Mass Spectrometry |
Mechanisms of Reactions |
NMR Spectroscopy |
Synthesis |
Student-Centered Learning
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Identification of an Unknown Compound by Combined Use of IR, 1H NMR, 13C NMR, and Mass Spectrometry: A Real-Life Experience in Structure Determination Louis J. Liotta and Magdalena James-Pederson
In this introductory organic chemistry experiment, students are expected to operate NMR, IR, and GCMS instrumentation to obtain spectra which are interpreted to elucidate the chemical structure of the assigned compounds without the benefit of a list of possible unknowns.
Liotta, Louis J.; James-Pederson, Magdalena. J. Chem. Educ. 2008, 85, 832.
Gas Chromatography |
Instrumental Methods |
IR Spectroscopy |
Mass Spectrometry |
Molecular Properties / Structure |
NMR Spectroscopy |
Qualitative Analysis |
Spectroscopy
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Analysis of the Thickening Agents in Automotive Greases by GC–MS David Mayotte, Craig J. Donahue, and Cheryl A. Snyder
Describes a laboratory procedure for the identification of the thickening agents in lubricating greases by GCMS.
Mayotte, David; Donahue, Craig J.; Snyder, Cheryl A. J. Chem. Educ. 2006, 83, 902.
Applications of Chemistry |
Consumer Chemistry |
Gas Chromatography |
Industrial Chemistry |
Mass Spectrometry |
Separation Science |
Fatty Acids
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Understanding Mass Spectra, A Basic Approach, Second Edition (R. Martin Smith) Bill Boggess
The interpretation of mass spectra represents arguably the most significant challenge to both newcomers and practitioners in the field of mass spectrometry (MS). For those of us who have ever struggled to use a mass spectrum to solve the structure of an organic compound, R. Martin Smith offers the second edition of Understanding Mass Spectra, A Basic Approach. Fortunately, the author manages to go well beyond the obvious and expected explanations of the common modes of fragmentation for ions generated during electron ionization (EI) by offering a rational approach to mass spectral problem solving. This ten-step approach, which represents the most important contribution of this text, appears in chapter 5 and is condensed into table 5.1.
Boggess, Bill. J. Chem. Educ. 2005, 82, 687.
Mass Spectrometry |
Instrumental Methods
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Syntheses and Characterization of Ruthenium(II) Tetrakis(Pyridine) Complexes. An Advanced Coordination Chemistry Experiment or Mini-Project Benjamin J. Coe
This experiment involves the syntheses of several coordination complexes of ruthenium(II) and their characterization by using various spectroscopic and spectrometric techniques.
Coe, Benjamin J. J. Chem. Educ. 2004, 81, 718.
Coordination Compounds |
IR Spectroscopy |
Synthesis |
Mass Spectrometry |
NMR Spectroscopy |
UV-Vis Spectroscopy
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Teaching Experimental Design Using a GC–MS Analysis of Cocaine on Money: A Cross-Disciplinary Laboratory Christopher A. Heimbuck and Nathan W. Bower
An opportunity for students to develop and use experimental designs to refine and optimize an extraction technique from the literature.
Heimbuck, Christopher A.; Bower, Nathan W. J. Chem. Educ. 2002, 79, 1254.
Drugs / Pharmaceuticals |
Forensic Chemistry |
Instrumental Methods |
Chemometrics |
Mass Spectrometry |
Gas Chromatography |
Separation Science |
Undergraduate Research
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Spectroscopy for Schools and Colleges [CD-ROM] (by the Royal Society of Chemistry and GlaxoWellcome) Thomas H. Eberlein
Interactive CR-ROM to assist in learning the fundamentals of interpreting spectroscopy in organic chemistry.
Eberlein, Thomas H. J. Chem. Educ. 2002, 79, 1204.
Spectroscopy |
NMR Spectroscopy |
IR Spectroscopy |
Mass Spectrometry |
Physical Properties |
Molecular Properties / Structure |
Enrichment / Review Materials
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Mass Spectral Fragmentation Patterns of Deuterated Butyl and Ethyl Acetates: An Easy Microscale Isotopic Labeling Experiment Hengameh Zahedkargaran and Leverett R. Smith
Microscale experiment that illustrates the use of isotopic labeling to help confirm and interpret mass spectral fragmentation patterns.
Zahedkargaran, Hengameh; Smith, Leverett R. J. Chem. Educ. 2001, 78, 1379.
Chromatography |
Isotopes |
Mass Spectrometry |
Microscale Lab |
Synthesis |
Gas Chromatography
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Antacids Revisited with Modern Chemical Instruments: GCMS, AAS, and CCT Stanley L. Burden and Christopher J. Petzold
This paper describes a novel experiment that requires students to obtain and interpret data from several analytical techniques to identify the brand name of a commercial antacid. They are required to design a set of experiments utilizing computer controlled titrations (CCT), atomic absorption (AA), gas chromatography-mass spectroscopy (GCMS), and careful quantitative manual titrations using a visual indicator of their choice to determine the brand name of their sample from a list of six to eight choices.
Burden, Stanley L.; Petzold, Christopher J. J. Chem. Educ. 1999, 76, 1544.
Chromatography |
Mass Spectrometry |
Titration / Volumetric Analysis |
Instrumental Methods |
Acids / Bases |
Qualitative Analysis
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Incorporation of GC-MS into an Environmental Science Curriculum Audrey E. McGowin and George G. Hess
Incorporating modern analytical instrumentation such as GC-MS into an interdisciplinary environmental science program presents many challenges. The most daunting challenge is the variety of disciplines from which students come and their limited understanding of chemistry and chemical analysis.
McGowin, Audrey E.; Hess, George G. J. Chem. Educ. 1999, 76, 23.
Chromatography |
Gas Chromatography |
Mass Spectrometry |
Instrumental Methods
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A New GC-MS Experiment for the Undergraduate Instrumental Analysis Laboratory in Environmental Chemistry: Methyl-t-butyl Ether and Benzene in Gasoline Dinh T. Quach, Nancy A. Ciszkowski, and Barbara J. Finlayson-Pitts
In addition to illustrating the fundamentals of GC and MS, this experiment demonstrates (i) the use of internal standards to improve precision; (ii) the application of the method of standard additions; and (iii) the importance of techniques such as selected ion extraction/monitoring in the identification and measurement of specific highly volatile organic compounds in complex environmental mixtures.
Quach, Dinh T.; Ciszkowski, Nancy A.; Finlayson-Pitts, Barbara J. J. Chem. Educ. 1998, 75, 1595.
Instrumental Methods |
Chromatography |
Mass Spectrometry |
Quantitative Analysis |
Gas Chromatography |
Aromatic Compounds |
Ethers
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1H NMR, 13C NMR, and Mass Spectrometry of 1-Phenyl-1,2-Dihaloethanes Joseph R. Gandler, Kevin W. Kittredge, and Oliver L. Saunders
Procedure to introduce organic chemistry students to spectroscopic methods for characterizing structure and calculating 13C NMR chemical shifts.
Gandler, Joseph R.; Kittredge, Kevin W.; Saunders, Oliver L. . J. Chem. Educ. 1995, 72, 855.
NMR Spectroscopy |
Mass Spectrometry
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Interpretation of mass spectra: A direct learning approach through software Lehman, Thomas; Vagenin, Grigory
Software available from NIST makes it possible for students to peruse 735 carefully chosen spectra.
Lehman, Thomas; Vagenin, Grigory J. Chem. Educ. 1993, 70, A316.
Mass Spectrometry
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Applications of autosampling GC-MS in an introductory organic chemistry laboratory Asleson, Gary L.; Doig, Marion T.; Heldrich, Frederick J.
Incorporation of an automated GC-MS has allowed students to have access to state-of-the-art instrumentation in a cost-effective and pedagogically sound manner.
Asleson, Gary L.; Doig, Marion T.; Heldrich, Frederick J. J. Chem. Educ. 1993, 70, A290.
Instrumental Methods |
Gas Chromatography |
Mass Spectrometry
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Qualitative amino acid analysis of small peptides by GC/MS Mabbott, Gary A.
Besides being appealing to students the exercise described here gives them experiences in derivation methods that are often necessary in order to make nonvolatile samples amenable to gas chromatography separation.
Mabbott, Gary A. J. Chem. Educ. 1990, 67, 441.
Amino Acids |
Qualitative Analysis |
Gas Chromatography |
Mass Spectrometry |
Instrumental Methods
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Mass spectral analysis of halogen compounds Holdsworth, David K.
37. Bits and pieces, 14. A pocket calculator can be programmed to decide and display the halogen combination in a molecular-ion cluster by examination of the (M+2)/M or (X+2)/X percentage values.
Holdsworth, David K. J. Chem. Educ. 1983, 60, 103.
Chemometrics |
Mass Spectrometry
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Rapid calculation of molecular formulas from mass values Lederberg, Joshua
Presents a table of mass fractions for all combinations of H, N, O, for the rapid calculation of molecular formulas from mass values.
Lederberg, Joshua J. Chem. Educ. 1972, 49, 613.
Chemometrics |
Molecular Properties / Structure |
Physical Properties |
Mass Spectrometry
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The calculation of relative abundance of isotope clusters in mass spectrometry Gorman, Mel; DeMattia, Dennis; Doonan, Daniel; Gohlke, R. S.
Describes the calculation of relative abundance of isotope clusters in mass spectrometry.
Gorman, Mel; DeMattia, Dennis; Doonan, Daniel; Gohlke, R. S. J. Chem. Educ. 1970, 47, 467.
Mass Spectrometry |
Quantitative Analysis |
Isotopes |
Nuclear / Radiochemistry |
Chemometrics
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Mass spectrometry Wiberley, Stephen E.; Aikens, David A.
Examines the theory of mass spectroscopy and factors that influence mass spectra.
Wiberley, Stephen E.; Aikens, David A. J. Chem. Educ. 1964, 41, A75.
Mass Spectrometry |
Spectroscopy |
Instrumental Methods |
Laboratory Equipment / Apparatus
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Spectrometric identification of organic compounds Silverstein, Robert M.; Bassler, G. Clayton
Presents a sequence of procedures for identifying an unknown organic liquid using mass, NMR, IR, and UV spectroscopy, along with specific examples of unknowns and their spectra,
Silverstein, Robert M.; Bassler, G. Clayton J. Chem. Educ. 1962, 39, 546.
Spectroscopy |
Qualitative Analysis |
Mass Spectrometry |
IR Spectroscopy |
NMR Spectroscopy |
UV-Vis Spectroscopy
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