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HIV-1 Protease: An Enzyme at Work This is "HIV-1 Protease: An Enzyme at Work", from a video tape published by the Journal of Chemical Education - Software as Special Issue 13
Applications of Chemistry |
Enzymes |
Proteins / Peptides |
Medicinal Chemistry
Journal Articles: First 3 results.
Pedagogies:
A Supramolecular Approach to Medicinal Chemistry: Medicine Beyond the MoleculeDavid K. Smith This article emphasizes a conceptual view of medicinal chemistry, which has important implications for the future, as the supramolecular approach to medicinal-chemistry products outlined here is rapidly allowing nanotechnology to converge with medicine. In particular, this article discusses recent developments including the rational design of drugs such as Relenza and Tamiflu, the mode of action of vancomycin, and the mechanism by which bacteria develop resistance, drug delivery using cyclodextrins, and the importance of supramolecular chemistry in understanding protein aggregation diseases such as Alzheimer's and CreutzfieldJacob. Smith, David K. J. Chem. Educ.2005, 82, 393.
Drugs / Pharmaceuticals |
Noncovalent Interactions |
Medicinal Chemistry |
Nanotechnology |
Proteins / Peptides
An NMR-Smell Module for the First-Semester General Chemistry LaboratoryErich S. Uffelman, Elizabeth H. Cox, J. Brown Goehring, Tyler S. Lorig, and C. Michele Davis The series of experiments involves an exploration of organic stereochemistry via hands-on model building, several chemosensory smell tests, and hands-on use of 13C NMR, thus serving as a powerful interdisciplinary lab involving chemistry, physics, and neuroscience. Similarities and differences between NMR and MRI methods are emphasized. Uffelman, Erich S.; Cox, Elizabeth H.; Goehring, J. Brown; Lorig, Tyler S.; Davis, C. Michele. J. Chem. Educ.2003, 80, 1368.
NMR Spectroscopy |
Stereochemistry |
Molecular Modeling |
Medicinal Chemistry
Risks and Chemical SubstancesBlumberg, Avrom A. We are exposed to about 50 thousand of the 12 million different substances that chemists have identified. This paper looks at how we become exposed within our homes, examine three important ways in which we identify and evaluate hazardous substances, and try to suggest a rational picture of the risks we face. Blumberg, Avrom A. J. Chem. Educ.1994, 71, 912.
Nitric Oxide-Releasing CompoundsWilliam F. Coleman, Randall J. Wildman The five WebWare Molecules for December derive from the article Nitrogen-Based Diazeniumdiolates: Versatile Nitric Oxide-Releasing Compounds for Biomedical Research and Potential Clinical Applications by Joseph E. Saavedra and Larry K. Keefer.
