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A Green, Guided-Inquiry Based Electrophilic Aromatic Substitution for the Organic Chemistry LaboratoryEric Eby and S. Todd Deal This alternative, electrophilic aromatic substitutionan iodination reaction of salicylamide, a popular analgesicuses environmentally friendly reagents and serves as a guided-inquiry experiment in which students are asked to predict the orientation of the substitution reaction and determine the product's structure using FT-IR spectroscopy. Eby, Eric; Deal, S. Todd. J. Chem. Educ.2008, 85, 1426.
Aromatic Compounds |
Constitutional Isomers |
Electrophilic Substitution |
Green Chemistry |
IR Spectroscopy |
Synthesis
Coupling Molecular Modeling to the Traditional "IR-ID" Exercise in the Introductory Organic Chemistry LaboratoryHeather Stokes-Huby and Dale E. Vitale In this exercise students are required to identify unknowns from their IR spectra, but must also match some of the absorptions with frequencies generate by computer molecular models. Animations of the corresponding bonds in the model are then used to obtain descriptions of the observed vibrations. Stokes-Huby, Heather; Vitale, Dale E. J. Chem. Educ.2007, 84, 1486.
Computational Chemistry |
IR Spectroscopy |
Liquids
Presumptive and Confirmatory Drug TestsCraig Anderson Tests for illegal drugs were performed on unknowns obtained from over-the-counter cold medicines. Substances that tested positive for the qualitative Marquis color test were found to be false positives for illegal substances, while scopolamine hydrochloride shows a false positive for cocaine hydrochloride with the cobalt thiocyanate reagent. Anderson, Craig. J. Chem. Educ.2005, 82, 1809.
The Spectra of Molecules: InfraredEd Vitz, John W. Moore A section of ChemPrime, the Chemical Educations Digital Library's free General Chemistry textbook.
IR Spectroscopy
3D NormalModes Shockwave; A Web Application for Interactive Visualization and Three Dimensional PercNickolas D. Charistos, C. A. Tsipis, Michael P. Sigalas 3D Normal Modes is a Web application for interactive visualization and three-dimensional perception of the normal modes of molecular vibration, suitable for undergraduate students in chemistry. The application uses the Macromedia Shockwave plug-in and has been designed and developed especially for the Web. It has a simple graphical user interface and requires a download of only 120 KB, allowing it to be used even with low bandwidth Internet connections. Its performance is comparable to a desktop application.
IR Spectroscopy |
Raman Spectroscopy
The Effect of Anharmonicity on Diatomic Vibration; A Spreadsheet SimulationWilliam F. Coleman, Kieran F. Lim Instructors and students can use this spreadsheet to quickly and easily observe how the shape of a one-dimensional vibrational potential energy curve and its associated vibrational quantum energy levels depend on the anharmonicity. This illustrates the connection between the harmonic (approximation) and anharmonic descriptions of molecular vibrations.