Journal Articles: 7 results
X-ray Diffraction and the Discovery of the Structure of DNA  David T. Crouse
Describes a step-by-step method of teaching the X-ray diffraction analysis of DNA using the approach employed by Watson, Crick, Wilkins, Franklin, and Gosling. Excerpts of their original articles describe the obstacles encountered by these researchers, the contributions made by each, and the degree to which X-ray diffraction aided their determination of DNA's structure.
Crouse, David T. J. Chem. Educ. 2007, 84, 803.
Biophysical Chemistry |
Crystals / Crystallography |
X-ray Crystallography |
Molecular Properties / Structure |
Molecular Modeling |
Nucleic Acids / DNA / RNA
Testing for Genetically Modified Foods Using PCR  Ann Taylor and Samin Sajan
The polymerase chain reaction (PCR) is a powerful technique used to detect and amplify a specific DNA sequence. In this experiment, DNA is isolated from commercially available corn meal and corn-muffin mixes, then a sequence unique to transgenic plants is amplified by PCR. The amplified sequence is identified by its size (192 base pairs) by agarose gel electrophoresis. This experiment could be used in either a biochemistry course or in an analytical chemistry course in a curriculum that integrates biochemistry throughout the course work.
Taylor, Ann; Sajan, Samin. J. Chem. Educ. 2005, 82, 597.
Agricultural Chemistry |
Constitutional Isomers |
Biotechnology |
Plant Chemistry |
Consumer Chemistry |
Nucleic Acids / DNA / RNA
An Attack on the AIDS Virus: Inhibition of the HIV-1 Protease. New Drug Development Based on the Structure and Activity of the Protease and its Role in the Replication and Maturation of the Virus  Volker, Eugene J.
Article shows how research into the biochemistry of HIV may lead to a method for controlling its growth and maturation. This research illustrates some basic enzyme chemistry and holds student appeal due to the tie into current affairs.
Volker, Eugene J. J. Chem. Educ. 1993, 70, 3.
Bioorganic Chemistry |
Proteins / Peptides |
Medicinal Chemistry |
Molecular Biology
Are high school students ready for recombinant DNA?: The UOP experience  Minch, Michael J.
What follows is a description of a three-week summer course on recombinant DNA offered to talented high school students between their junior and senior years.
Minch, Michael J. J. Chem. Educ. 1989, 66, 64.
Molecular Biology
Supercoiled DNA   Scovell, William M.
This article reviews recent advances in our knowledge of Supercoiled DNA such as topology, energetic, and physicochemical characteristics as well as the biological implications of this tertiary structure.
Scovell, William M. J. Chem. Educ. 1986, 63, 562.
Molecular Biology
Separation of glycohemoglobins by ion exchange chromatography: An undergraduate biochemistry laboratory experiment  Jackman, Lance E.
In this experiment, students determine the glycohemoglobin level of whole blood samples by separation of the glycohemoglobins from the nonglycosylated hemoglobins using cation exchange chromatography.
Jackman, Lance E. J. Chem. Educ. 1981, 58, 77.
Chromatography |
Separation Science |
Ion Exchange |
Molecular Biology
Hemocyanin: The copper blood  Senozan, N. M.
The author contrasts hemocyanin against hemoglobin and discusses the occurrence of hemocyanin; oxygen and hemocyanin; the details of the oxygenation curves; Bohr effect and the respiration of squids and snails; and dissociation of association of hemocyanin.
Senozan, N. M. J. Chem. Educ. 1976, 53, 684.
Molecular Biology |
Medicinal Chemistry |
Bioinorganic Chemistry |
Biological Cells |
Applications of Chemistry |