Journal Articles: 9 results
A-DNA and B-DNA: Comparing Their Historical X-ray Fiber Diffraction Images  Amand A. Lucas
This paper provides a comparative explanation of the structural content of the diffraction diagrams of A-DNA and B-DNA that facilitated the discovery of the double-helical structure of DNA by Watson and Crick in 1953. This analysis is supported a method that simulates both A-DNA and B-DNA X-ray images optically.
Lucas, Amand A. J. Chem. Educ. 2008, 85, 737.
Biophysical Chemistry |
Conformational Analysis |
Crystals / Crystallography |
X-ray Crystallography |
Nucleic Acids / DNA / RNA
A 3D Model of Double-Helical DNA Showing Variable Chemical Details  Susan G. Cady
A 3D double-helical DNA model, made by placing beads on a wire and stringing beads through holes in plastic canvas, is described. Suggestions are given to enhance the basic helical frame to show the shapes and sizes of the nitrogenous base rings, 3' and 5' chain termini, and base pair hydrogen bonding. Students can incorporate random or real gene sequence data into their models.
Cady, Susan G. J. Chem. Educ. 2005, 82, 79.
Biotechnology |
Molecular Properties / Structure |
Molecular Modeling |
Nucleic Acids / DNA / RNA
Genetic Code Wordsearch  Terry L. Helser
Wordsearch puzzle containing 30 words that describe the nucleotide sequences used to produce proteins.
Helser, Terry L. J. Chem. Educ. 2003, 80, 417.
Biotechnology |
Nomenclature / Units / Symbols |
Enrichment / Review Materials |
Nucleic Acids / DNA / RNA
Revealing the Backbone Structure of B-DNA from Laser Optical Simulations of Its X-ray Diffraction Diagram  A. A. Lucas, Ph. Lambin, R. Mairesse, and M. Mathot
A visible laser and a set of nine specially designed diffraction gratings held on a single slide have been used to build up progressively a classroom optical simulation of the diffraction of X-rays by a B-DNA fiber. The nine optical transforms allow understanding, without recourse to helical diffraction theory, of how the prominent features of the observed diffraction pattern arise from each of the structural parameters of the DNA backbone.
Lucas, A. A.; Lambin, Ph.; Mairesse, R.; Mathot, M. J. Chem. Educ. 1999, 76, 378.
Crystals / Crystallography |
X-ray Crystallography |
Molecular Properties / Structure |
Nucleic Acids / DNA / RNA
Detection of Non-B-DNA Secondary Structures by S1 Nuclease Digestion  Marcel.li del Olmo, Agustin Aranda, Jose E. Perez-Ortin, and Vicente Tordera
Two cheap and simple laboratory experiments to analyze the different topological states of DNA and, simultaneously, to detect denatured regions and cruciforms in vitro, using the single-strand specific S1 nuclease.
del Olmo, Marcel.l; Aranda, Agustn; Perez-Ortn, Jos E.; Tordera, Vicente. J. Chem. Educ. 1998, 75, 762.
Electrophoresis |
Enzymes |
Amino Acids |
Molecular Properties / Structure
An Attack on the AIDS Virus: Inhibition of the HIV-1 Protease. New Drug Development Based on the Structure and Activity of the Protease and its Role in the Replication and Maturation of the Virus  Volker, Eugene J.
Article shows how research into the biochemistry of HIV may lead to a method for controlling its growth and maturation. This research illustrates some basic enzyme chemistry and holds student appeal due to the tie into current affairs.
Volker, Eugene J. J. Chem. Educ. 1993, 70, 3.
Bioorganic Chemistry |
Proteins / Peptides |
Medicinal Chemistry |
Molecular Biology
Biochemical consequences of lipid peroxidation  Bland, Jeffrey
The mechanism of formation of lipid peroxides and their biochemical roles in observed changes in cellular proteins, enzymes, and nucleotides, lipofusion and period pigment formation, cellular aging, membrane alteration, crosslinking of collagen, and drug/chemical-induced pathologies constitute the focus of this report.
Bland, Jeffrey J. Chem. Educ. 1978, 55, 151.
Drugs / Pharmaceuticals |
Lipids |
Proteins / Peptides |
Enzymes |
Transport Properties |
Medicinal Chemistry
The Molecular Basis of Evolution (Anfinsen, Christian B.)  Edsall, John T.

Edsall, John T. J. Chem. Educ. 1960, 37, 107.
Molecular Biology
Isomers of octahedral complexes with nonbranching ligands  Trimble, Russell F., Jr.
The purpose of this paper is to present a tabulation of the various ways in which ligands can be distributed about an octahedral frame.
Trimble, Russell F., Jr. J. Chem. Educ. 1954, 31, 176.
Coordination Compounds |
Molecular Biology |