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For the textbook, chapter, and section you specified we found
3 Videos
7 Assessment Questions
16 Molecular Structures
8 Journal Articles
19 Other Resources
Videos: 3 results
Factors Affecting Glucose Oxidase Activity  
Various factors which affect glucose oxidase activity are demonstrated.
Catalysis |
Enzymes |
Kinetics |
Proteins / Peptides
Halting the Briggs-Rauscher Oscillating Reaction  
The Briggs-Rauscher reaction is demonstrated in three different ways. Catalase from a liver extract decomposes the hydrogen peroxide in an Briggs-Rauscher reaction, stopping the oscillations.
Catalysis |
Kinetics |
Enzymes |
Proteins / Peptides
HIV-1 Protease: An Enzyme at Work  
This is "HIV-1 Protease: An Enzyme at Work", from a video tape published by the Journal of Chemical Education - Software as Special Issue 13
Applications of Chemistry |
Enzymes |
Proteins / Peptides |
Medicinal Chemistry
Assessment Questions: First 3 results
Biochemistry : HBondingDNA (9 Variations)
The structure and replication of DNA are strongly dependent on the hydrogen bonding system present in the double helix. How many functional groups in thymine can participate in hydrogen bonding? (This means all the groups, not just the ones that actually participate in hydrogen bonding in the double helix.)

Nucleic Acids / DNA / RNA
Biochemistry : Replication (8 Variations)
Which of the following is NOT a feature of replication?
Nucleic Acids / DNA / RNA
Biochemistry : ComplementaryDNA (20 Variations)
Determine the sequence of the complementary DNA strand for the following sequence. (Note: Complementary strands match up 5' ends to 3' ends.)
5'-TAATGAGT-3'

Nucleic Acids / DNA / RNA
View all 7 results
Molecular Structures: First 3 results
uracil C4H4N2O2

3D Structure

Link to PubChem

Nucleic Acids / DNA / RNA |
Amides

thymine C5H6N2O2

3D Structure

Link to PubChem

Nucleic Acids / DNA / RNA |
Aromatic Compounds |
Amides

dihydro-thymine C5H8N2O2

3D Structure

Link to PubChem

Amides |
Nucleic Acids / DNA / RNA |
Heterocycles

View all 16 results
Journal Articles: First 3 results.
Pedagogies:
Fluorescence Spectroscopy of tRNAPhe Y Base in the Presence of Mg2+ and Small Molecule Ligands  Sarah R. Kirk, Todd P. Silverstein, and Karen L. McFarlane Holman
This article describes a set of experiments in which ligands (e.g., spermine, neomycin B, magnesium) are titrated into tRNAPhe solution and fluorescence spectroscopy is used to draw conclusions on how different binding modes affect tRNAPhe tertiary structure.
Kirk, Sarah R.; Silverstein, Todd P.; Holman, Karen L. McFarlane. J. Chem. Educ. 2008, 85, 678.
Bioinorganic Chemistry |
Bioorganic Chemistry |
Biophysical Chemistry |
Fluorescence Spectroscopy |
Nucleic Acids / DNA / RNA
Metal-Catalyzed Cleavage of tRNAPhe  Sarah R. Kirk, Todd P. Silverstein, and Karen L. McFarlane Holman
This article describes a set of experiments in which students study tRNAPhe conformational changes induced by ligand binding using gel electrophoresis to determine how metal-catalyzed hydrolysis is affected by parameters such as tRNAPhe structure, ligand charge, and the chemistry of the metal ion complexes involved.
Kirk, Sarah R.; Silverstein, Todd P.; Holman, Karen L. McFarlane. J. Chem. Educ. 2008, 85, 676.
Bioinorganic Chemistry |
Bioorganic Chemistry |
Electrophoresis |
Nucleic Acids / DNA / RNA
UV Thermal Melting Curves of tRNAPhe in the Presence of Ligands  Sarah R. Kirk, Todd P. Silverstein, and Karen L. McFarlane Holman
This article describes a set of experiments in which the thermal unfolding of tRNAPhe is studied with UVvis spectrophotometry. Students examine the effects of magnesium and small molecule ligands on tRNAPhe conformational stability and draw conclusions about tRNAPhe ligand binding modes and the impact of various types of ligands on tRNA structure.
Kirk, Sarah R.; Silverstein, Todd P.; Holman, Karen L. McFarlane. J. Chem. Educ. 2008, 85, 674.
Bioinorganic Chemistry |
Bioorganic Chemistry |
Biophysical Chemistry |
Thermal Analysis |
UV-Vis Spectroscopy |
Nucleic Acids / DNA / RNA
View all 8 articles
Other Resources: First 3 results
Netorials  
The Netorials cover selected topics in first-year chemistry including: Chemical Reactions, Stoichiometry, Intermolecular Forces, Acids & Bases, Biomolecules, and Electrochemistry.
Acids / Bases |
Stoichiometry |
Proteins / Peptides |
Enzymes |
Carbohydrates |
Nucleic Acids / DNA / RNA |
Lipids |
Oxidation / Reduction |
Noncovalent Interactions
Molecular Models of DNA  William F. Coleman
The featured molecules this month come from the paper by David T. Crouse on the X-ray determination of the structure of DNA. Given that most students are aware of the double helix, it seems appropriate to back up a little and examine the components that give rise to this structure. Accordingly, the molecule collection includes: Purine and pyrimidine, structural precursors of the four bases found in DNA: cytosine (C), thymine (T), adenine (A), and guanine (G) The four corresponding deoxyribonucleosides The four deoxyribonucleotides (the nucleoside monophosphates) A two-base-pair fragment showing the AT and GC hydrogen-bonded complements Several small 24-base-pair DNA fragments polyAT, polyGC, and a random array of bases. The DNA fragments provide a good opportunity to have students explore features of the Jmol and Chime menus. Using the Jmol menu as an example (right-click on the structure to bring up the menu) students can use the measuring tools to get an idea of the length of a complete turn in the DNA, the relative widths of the major and minor grooves, and the diameter of the helix. They can use the coloring schemes to detect the various base pair combinations, and learn to read the code for the random sequence. In Chime they can use the Shapely coloring scheme for this same purpose. Exploring other aspects of the menu will allow students to present the molecules in the various forms, including ribbon and cartoon views. In RNA, thymine is replaced by uracil, and the sugar moiety has an axial hydroxyl group on the carbon atom adjacent to the base binding site (the 2? carbon). The structures of uracil and of uridine monophosphate are included in the molecule collection. Students can use the Web to download and examine more complex DNAs using a site such as the Nucleic Acid Database at Rutgers University.
Nucleic Acids / DNA / RNA
Molecular Models of DAPI  William F. Coleman
This month's Featured Molecule is DAPI (4′,6-diamidino-2-phenylindole), from the paper by Eamonn F. Healy (1). The utility of DAPI is a consequence of its being a minor-groove binder to DNA. A crystal structure of DAPI binding to the minor groove of a synthetic DNA has been determined, and the structure file made available through the RCSB Protein Data Bank (2, 3). That structure is also included in the Featured Molecules Collection, with the water molecules removed for the sake of clarity. For many students this may be their first encounter with the binding of small molecules to DNA. Another example of such binding is the intercalation of the antibiotic actinomycin into DNA. The Department of Biology at the University of Hamburg maintains an excellent Web site showing both crystal and NMR structures of actinomycin intercalation (4). Observant students will also note in the structure of DAPI a theme that has appeared several times in our Featured Molecules, and that is the non-planarity of adjacent delocalized ring systems. In DAPI, it is a five-membered ring adjacent to a six-membered ring, and the observed departure from planarity is less than that in biphenyl. Students might be asked to explain that difference.
Nucleic Acids / DNA / RNA
View all 19 results