TIGER

Journal Articles: 11 results
A-DNA and B-DNA: Comparing Their Historical X-ray Fiber Diffraction Images  Amand A. Lucas
This paper provides a comparative explanation of the structural content of the diffraction diagrams of A-DNA and B-DNA that facilitated the discovery of the double-helical structure of DNA by Watson and Crick in 1953. This analysis is supported a method that simulates both A-DNA and B-DNA X-ray images optically.
Lucas, Amand A. J. Chem. Educ. 2008, 85, 737.
Biophysical Chemistry |
Conformational Analysis |
Crystals / Crystallography |
X-ray Crystallography |
Nucleic Acids / DNA / RNA
X-ray Diffraction and the Discovery of the Structure of DNA  David T. Crouse
Describes a step-by-step method of teaching the X-ray diffraction analysis of DNA using the approach employed by Watson, Crick, Wilkins, Franklin, and Gosling. Excerpts of their original articles describe the obstacles encountered by these researchers, the contributions made by each, and the degree to which X-ray diffraction aided their determination of DNA's structure.
Crouse, David T. J. Chem. Educ. 2007, 84, 803.
Biophysical Chemistry |
Crystals / Crystallography |
X-ray Crystallography |
Molecular Properties / Structure |
Molecular Modeling |
Nucleic Acids / DNA / RNA
A Unique Demonstration Model of DNA  Jonathan P. L. Cox
Describes a physical demonstration model of DNA for the classroom. The model comprises two types of building blocks that can be put together rapidly to produce an abstract structure that portrays several of the gross architectural features of idealized B-DNA.
Cox, Jonathan P. L. J. Chem. Educ. 2006, 83, 1319.
Molecular Biology |
Molecular Properties / Structure |
Student-Centered Learning |
Nucleic Acids / DNA / RNA
Testing for Ultraviolet Toxicity Using Fungi  Marcelo Vital and Patricia Esperón
In this article, we describe a laboratory project quantifying the effects of UV radiation on a suspension of living cells. This laboratory experiment was designed for undergraduate students in biochemistry. The experiment was carried out employing different fungi strains, changing the dosage of radiation, the distance to the UV source, and the exposure period to the UV radiation. The quantity of viable spores was calculated and the dose¬Ěresponse curves were drawn. Students were able to prove that 100% of mortality was achieved with the longest time of exposure.
Vital, Marcelo; Esperón, Patricia. J. Chem. Educ. 2005, 82, 926.
Nucleic Acids / DNA / RNA |
UV-Vis Spectroscopy |
Medicinal Chemistry |
Molecular Biology |
Photochemistry
A 3D Model of Double-Helical DNA Showing Variable Chemical Details  Susan G. Cady
A 3D double-helical DNA model, made by placing beads on a wire and stringing beads through holes in plastic canvas, is described. Suggestions are given to enhance the basic helical frame to show the shapes and sizes of the nitrogenous base rings, 3' and 5' chain termini, and base pair hydrogen bonding. Students can incorporate random or real gene sequence data into their models.
Cady, Susan G. J. Chem. Educ. 2005, 82, 79.
Biotechnology |
Molecular Properties / Structure |
Molecular Modeling |
Nucleic Acids / DNA / RNA
DNA Topology Analysis in the Undergraduate Biochemistry Laboratory  Michael V. Keck
A set of complementary experiments is described which are useful in teaching the principles of DNA topology to undergraduate biochemistry students.
Keck, Michael V. J. Chem. Educ. 2000, 77, 1471.
Drugs / Pharmaceuticals |
Electrophoresis |
Molecular Properties / Structure |
Nucleic Acids / DNA / RNA
Liver and Onions: DNA Extraction from Animal and Plant Tissues  Karen J. Nordell, Anne-Marie L. Jackelen, S. Michael Condren, George C. Lisensky, and Arthur B. Ellis*
This activity, which allows students to extract DNA from plant and animal cells, serves as a spectacular example of the complexity of biochemical structure and function and fits well with a discussion of nucleic acids, hydrogen bonding, genetic coding, and heredity. DNA extraction can also be used in conjunction with a discussion of polymers and their properties.
Nordell, Karen J.; Jackelen, Anne-Marie L.; Condren, S. Michael; Lisensky, George C.; Ellis, Arthur B. J. Chem. Educ. 1999, 76, 400A.
Hydrogen Bonding |
Molecular Properties / Structure |
Nucleic Acids / DNA / RNA
An Attack on the AIDS Virus: Inhibition of the HIV-1 Protease. New Drug Development Based on the Structure and Activity of the Protease and its Role in the Replication and Maturation of the Virus  Volker, Eugene J.
Article shows how research into the biochemistry of HIV may lead to a method for controlling its growth and maturation. This research illustrates some basic enzyme chemistry and holds student appeal due to the tie into current affairs.
Volker, Eugene J. J. Chem. Educ. 1993, 70, 3.
Bioorganic Chemistry |
Proteins / Peptides |
Medicinal Chemistry |
Molecular Biology
Nucleic acid structure and synthesis (Parish, J.H.)  Parker, Keith K.
A review of a software program designed to introduce current understanding of DNA and RNA structure and the dynamic processes of replication and transcription.
Parker, Keith K. J. Chem. Educ. 1988, 65, A298.
Molecular Biology
Supercoiled DNA   Scovell, William M.
This article reviews recent advances in our knowledge of Supercoiled DNA such as topology, energetic, and physicochemical characteristics as well as the biological implications of this tertiary structure.
Scovell, William M. J. Chem. Educ. 1986, 63, 562.
Molecular Biology
The effects of ionizing radiation on mammalian cells  Biaglow, John E.
In this review, the author is concerned with the effects of radiation on dividing cells and the factors that influence it.
Biaglow, John E. J. Chem. Educ. 1981, 58, 144.
Medicinal Chemistry |
Free Radicals |
Nuclear / Radiochemistry |
Molecular Biology |
Applications of Chemistry