TIGER

Click on the title of a resource to view it. To save screen space, only the first 3 resources are shown. You can display more resources by scrolling down and clicking on “View all xx results”.

For the textbook, chapter, and section you specified we found
4 Assessment Questions
16 Molecular Structures
6 Journal Articles
13 Other Resources
Assessment Questions: First 3 results
Biochemistry : HBondingDNA (9 Variations)
The structure and replication of DNA are strongly dependent on the hydrogen bonding system present in the double helix. How many functional groups in thymine can participate in hydrogen bonding? (This means all the groups, not just the ones that actually participate in hydrogen bonding in the double helix.)

Nucleic Acids / DNA / RNA
Biochemistry : Replication (8 Variations)
Which of the following is NOT a feature of replication?
Nucleic Acids / DNA / RNA
Biochemistry : ComplementaryDNA (20 Variations)
Determine the sequence of the complementary DNA strand for the following sequence. (Note: Complementary strands match up 5' ends to 3' ends.)
5'-TAATGAGT-3'

Nucleic Acids / DNA / RNA
View all 4 results
Molecular Structures: First 3 results
uracil C4H4N2O2

3D Structure

Link to PubChem

Nucleic Acids / DNA / RNA |
Amides

thymine C5H6N2O2

3D Structure

Link to PubChem

Nucleic Acids / DNA / RNA |
Aromatic Compounds |
Amides

dihydro-thymine C5H8N2O2

3D Structure

Link to PubChem

Amides |
Nucleic Acids / DNA / RNA |
Heterocycles

View all 16 results
Journal Articles: First 3 results.
Pedagogies:
A-DNA and B-DNA: Comparing Their Historical X-ray Fiber Diffraction Images  Amand A. Lucas
This paper provides a comparative explanation of the structural content of the diffraction diagrams of A-DNA and B-DNA that facilitated the discovery of the double-helical structure of DNA by Watson and Crick in 1953. This analysis is supported a method that simulates both A-DNA and B-DNA X-ray images optically.
Lucas, Amand A. J. Chem. Educ. 2008, 85, 737.
Biophysical Chemistry |
Conformational Analysis |
Crystals / Crystallography |
X-ray Crystallography |
Nucleic Acids / DNA / RNA
Quantitative Determination of DNA–Ligand Binding Using Fluorescence Spectroscopy  Eamonn F. Healy
The experiment described here measures the DAPI (4',6-diamidino-2-phenylindole) binding constant for calf-thymus DNA using fluorescence measurements and a modified Scatchard analysis. Student can estimate DAPI occupancy of the minor groove in DNA by calculating the number of nucleotides per bound ligand.
Healy, Eamonn F. J. Chem. Educ. 2007, 84, 1304.
Bioanalytical Chemistry |
Drugs / Pharmaceuticals |
Fluorescence Spectroscopy |
Medicinal Chemistry |
Nucleic Acids / DNA / RNA
A 3D Model of Double-Helical DNA Showing Variable Chemical Details  Susan G. Cady
A 3D double-helical DNA model, made by placing beads on a wire and stringing beads through holes in plastic canvas, is described. Suggestions are given to enhance the basic helical frame to show the shapes and sizes of the nitrogenous base rings, 3' and 5' chain termini, and base pair hydrogen bonding. Students can incorporate random or real gene sequence data into their models.
Cady, Susan G. J. Chem. Educ. 2005, 82, 79.
Biotechnology |
Molecular Properties / Structure |
Molecular Modeling |
Nucleic Acids / DNA / RNA
View all 6 articles
Other Resources: First 3 results
Molecular Models of DNA  William F. Coleman
The featured molecules this month come from the paper by David T. Crouse on the X-ray determination of the structure of DNA. Given that most students are aware of the double helix, it seems appropriate to back up a little and examine the components that give rise to this structure. Accordingly, the molecule collection includes: Purine and pyrimidine, structural precursors of the four bases found in DNA: cytosine (C), thymine (T), adenine (A), and guanine (G) The four corresponding deoxyribonucleosides The four deoxyribonucleotides (the nucleoside monophosphates) A two-base-pair fragment showing the AT and GC hydrogen-bonded complements Several small 24-base-pair DNA fragments polyAT, polyGC, and a random array of bases. The DNA fragments provide a good opportunity to have students explore features of the Jmol and Chime menus. Using the Jmol menu as an example (right-click on the structure to bring up the menu) students can use the measuring tools to get an idea of the length of a complete turn in the DNA, the relative widths of the major and minor grooves, and the diameter of the helix. They can use the coloring schemes to detect the various base pair combinations, and learn to read the code for the random sequence. In Chime they can use the Shapely coloring scheme for this same purpose. Exploring other aspects of the menu will allow students to present the molecules in the various forms, including ribbon and cartoon views. In RNA, thymine is replaced by uracil, and the sugar moiety has an axial hydroxyl group on the carbon atom adjacent to the base binding site (the 2? carbon). The structures of uracil and of uridine monophosphate are included in the molecule collection. Students can use the Web to download and examine more complex DNAs using a site such as the Nucleic Acid Database at Rutgers University.
Nucleic Acids / DNA / RNA
Molecular Models of DAPI  William F. Coleman
This month's Featured Molecule is DAPI (4′,6-diamidino-2-phenylindole), from the paper by Eamonn F. Healy (1). The utility of DAPI is a consequence of its being a minor-groove binder to DNA. A crystal structure of DAPI binding to the minor groove of a synthetic DNA has been determined, and the structure file made available through the RCSB Protein Data Bank (2, 3). That structure is also included in the Featured Molecules Collection, with the water molecules removed for the sake of clarity. For many students this may be their first encounter with the binding of small molecules to DNA. Another example of such binding is the intercalation of the antibiotic actinomycin into DNA. The Department of Biology at the University of Hamburg maintains an excellent Web site showing both crystal and NMR structures of actinomycin intercalation (4). Observant students will also note in the structure of DAPI a theme that has appeared several times in our Featured Molecules, and that is the non-planarity of adjacent delocalized ring systems. In DAPI, it is a five-membered ring adjacent to a six-membered ring, and the observed departure from planarity is less than that in biphenyl. Students might be asked to explain that difference.
Nucleic Acids / DNA / RNA
Information Storage in Sports, Physiology & Health  Tim Wendorff
A section of ChemPrime, the Chemical Educations Digital Library's free General Chemistry textbook.
Nucleic Acids / DNA / RNA
View all 13 results