TIGER

Journal Articles: 12 results
Molecules and Medicine (E. J. Corey, Barbara Czakó, and László Kürti)  Robert E. Buntrock
Looking for a book on common drugs and pharmaceuticals? On diseases and medical conditions? On pharmacology? In addition, do you need some background in chemistry to handle all of this information? If you want all of this, and in addition want it under one cover, then this is the book for you.
Buntrock, Robert E. J. Chem. Educ. 2008, 85, 1495.
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Molecular Properties / Structure |
Proteins / Peptides |
Synthesis |
Toxicology
Mentoring an Undergraduate Research Student in the Structural and Nonstructural Properties of Drugs  Julie B. Ealy and Veronica Kvarta
This article describes research, conducted with an undergraduate, to investigate the structural and nonstructural characteristics of drugs and their significance in drug research.
Ealy, Julie B.; Kvarta, Veronica. J. Chem. Educ. 2006, 83, 1779.
Applications of Chemistry |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Molecular Modeling |
Molecular Properties / Structure |
Undergraduate Research |
Student-Centered Learning
Nature's Way To Make the Lantibiotics  Heather A. Relyea and Wilfred A. van der Donk
This article focuses on one class of antimicrobial compounds, the lantibiotics, and discusses their biosynthetic pathways as well as their molecular mode of action. In the course of the review, the meaning of the terms regio-, chemo-, and stereoselectivity are discussed.
Relyea, Heather A.; van der Donk, Wilfred A. J. Chem. Educ. 2006, 83, 1769.
Applications of Chemistry |
Bioorganic Chemistry |
Biotechnology |
Biosynthesis |
Catalysis |
Drugs / Pharmaceuticals |
Proteins / Peptides
A Supramolecular Approach to Medicinal Chemistry: Medicine Beyond the Molecule  David K. Smith
This article emphasizes a conceptual view of medicinal chemistry, which has important implications for the future, as the supramolecular approach to medicinal-chemistry products outlined here is rapidly allowing nanotechnology to converge with medicine. In particular, this article discusses recent developments including the rational design of drugs such as Relenza and Tamiflu, the mode of action of vancomycin, and the mechanism by which bacteria develop resistance, drug delivery using cyclodextrins, and the importance of supramolecular chemistry in understanding protein aggregation diseases such as Alzheimer's and CreutzfieldJacob.
Smith, David K. J. Chem. Educ. 2005, 82, 393.
Drugs / Pharmaceuticals |
Noncovalent Interactions |
Medicinal Chemistry |
Nanotechnology |
Proteins / Peptides
Milk as a Drug Analysis Medium: HPLC Determination of Isoniazid  Enzo Sottofattori, Riccardo Raggio, and Olga Bruno
Using milk as a safer biological fluid for drug analysis; detecting isoniazid in cow's milk through HPLC.
Sottofattori, Enzo; Raggio, Riccardo; Bruno, Olga. J. Chem. Educ. 2003, 80, 547.
Chromatography |
Drugs / Pharmaceuticals |
Food Science |
Proteins / Peptides |
HPLC |
Quantitative Analysis |
Applications of Chemistry
An Indexed Combinatorial Library: The Synthesis and Testing of Insect Repellents  William H. Miles, Kathy A. Gelato, Kristen M. Pompizzi, Aislinn M. Scarbinsky, Brian K. Albrecht, and Elaine R. Reynolds
An indexed combinatorial library of amides was prepared by the reaction of amines and acid chlorides; a simple test for insect repellency using fruit flies (Drosophila melanogaster) allowed the determination of the most repellent sublibraries.
Miles, William H.; Gelato, Kathy A.; Pompizzi, Kristen M.; Scarbinsky, Aislinn M.; Albrecht, Brian K.; Reynolds, Elaine R. J. Chem. Educ. 2001, 78, 540.
Drugs / Pharmaceuticals |
Synthesis |
Combinatorial Chemistry |
Applications of Chemistry |
Amines / Ammonium Compounds
Exploring the Ocean- Stating the Case for Chemistry  Paul J. Scheuer
Salinity measurements and carbonate-bicarbonate equilibria used to be the only topics studied under what was known as "marine chemistry". But in the past few decades organic chemists have changed this situation profoundly by exploring the diverse fauna and flora of coral reefs and the ocean floor.
Scheuer, Paul J. J. Chem. Educ. 1999, 76, 1075.
Natural Products |
Drugs / Pharmaceuticals |
Applications of Chemistry
Immobilized Lactase in the Biochemistry Laboratory  Matthew J. Allison and C. Larry Bering
Lactase from over-the-counter tablets for patients with lactose intolerance is immobilized in polyacrylamide, which is then milled into small beads and placed into a chromatography column. A lactose solution is added to the column and the eluant is assayed using the glucose oxidase assay, available as a kit.
Allison, Matthew J.; Bering, C. Larry. J. Chem. Educ. 1998, 75, 1278.
Enzymes |
Biotechnology
The Art and Science of Organic and Natural Products Synthesis  K. C. Nicolaou, E. J. Sorensen, and N. Winssinger
In this article, the history of the art and science of organic and natural products synthesis is briefly reviewed and the state of the art is discussed. The impact of this discipline on biology and medicine is amply demonstrated with examples, and projections for future developments in the field are made.
Nicolaou, K. C.; Sorensen, E. J.; Winssinger, N. J. Chem. Educ. 1998, 75, 1225.
Natural Products |
Synthesis |
Medicinal Chemistry |
Applications of Chemistry |
Drugs / Pharmaceuticals
Drug stabilization against oxidative degradation  Akers, Michael J.
Describes the process of oxidation and ways in which pharmaceutical preparations can be protected from oxidative degredation.
Akers, Michael J. J. Chem. Educ. 1985, 62, 325.
Drugs / Pharmaceuticals |
Oxidation / Reduction |
Medicinal Chemistry |
Nonmajor Courses
A new chemistry program for nursing and allied health students  Stanitski, Conrad L.; Sears, Curtis T., Jr.
Outlines and discusses the topics considered in a chemistry program for nursing and allied health students.
Stanitski, Conrad L.; Sears, Curtis T., Jr. J. Chem. Educ. 1975, 52, 226.
Nonmajor Courses |
Applications of Chemistry |
Medicinal Chemistry |
Oxidation / Reduction |
Catalysis |
Acids / Bases |
pH |
Metabolism |
Drugs / Pharmaceuticals
A multidimensional experiment. Synthesis of sulfa drug and its use as a chemotherapeutic agent  Krantz, A.; Jesaitis, R. G.
Students synthesize sulfanilamide or sulfathiazole and independently investigate their effect on bacteria cultures.
Krantz, A.; Jesaitis, R. G. J. Chem. Educ. 1973, 50, 76.
Synthesis |
Drugs / Pharmaceuticals