| Journal Articles: 19 results |
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The A1c Blood Test: An Illustration of Principles from General and Organic Chemistry Robert C. Kerber
The glycated hemoglobin blood test is a key measure of the effectiveness of glucose control in diabetics. The chemistry of glucose in the bloodstream, which underlies the test and its impact, provides an illustration of the importance of chemical equilibrium and kinetics to a major health problem.
Kerber, Robert C. . J. Chem. Educ. 2007, 84, 1541.
Applications of Chemistry |
Bioinorganic Chemistry |
Carbohydrates |
Mechanisms of Reactions |
Proteins / Peptides |
Bioorganic Chemistry
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A Green Polymerization of Aspartic Acid for the Undergraduate Organic Laboratory George D. Bennett
Based on a technology that won a Presidential Green Chemistry Challenge Award, this experiment involves the thermal polymerization of aspartic acid and subsequent hydrolysis to give sodium poly(aspartate). The procedure is suitable for introducing students to the important topic of polymers and for illustrating several of the principles of green chemistry.
Bennett, George D. J. Chem. Educ. 2005, 82, 1380.
Green Chemistry |
Synthesis |
Industrial Chemistry |
Natural Products |
Polymerization |
Proteins / Peptides
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A Supramolecular Approach to Medicinal Chemistry: Medicine Beyond the Molecule David K. Smith
This article emphasizes a conceptual view of medicinal chemistry, which has important implications for the future, as the supramolecular approach to medicinal-chemistry products outlined here is rapidly allowing nanotechnology to converge with medicine. In particular, this article discusses recent developments including the rational design of drugs such as Relenza and Tamiflu, the mode of action of vancomycin, and the mechanism by which bacteria develop resistance, drug delivery using cyclodextrins, and the importance of supramolecular chemistry in understanding protein aggregation diseases such as Alzheimer's and CreutzfieldJacob.
Smith, David K. J. Chem. Educ. 2005, 82, 393.
Drugs / Pharmaceuticals |
Noncovalent Interactions |
Medicinal Chemistry |
Nanotechnology |
Proteins / Peptides
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A Modular Laser Apparatus for Polarimetry, Nephelometry, and Fluorimetry in General Chemistry Scott A. Darveau, Jessica Mueller, April Vaverka, Cheri Barta, Anthony Fitch, Jessica Jurzenski, and Yvonne Gindt
We present an apparatus suitable for multiple uses in the general chemistry laboratory including polarimetry, fluorescence, and nephelometry. The open design of the instrument also decreases the chance that students will contract the "black-box syndrome" that seems to develop when using instruments that only provide the final data in an experiment without showing how the measurements are obtained.
Darveau, Scott A.; Mueller, Jessica; Vaverka, April; Barta, Cheri; Fitch, Anthony; Jurzenski, Jessica; Gindt, Yvonne. J. Chem. Educ. 2004, 81, 401.
Fluorescence Spectroscopy |
Kinetics |
Laboratory Equipment / Apparatus |
Lasers |
Spectroscopy |
Proteins / Peptides |
Water / Water Chemistry
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Homogeneous Immunoassays: Historical Perspective and Future Promise Edwin F. Ullman
The founding and growth of Syva Company is examined in the context of its leadership role in the development of homogeneous immunoassays. The simple mix and read protocols of these methods offer advantages in routine analytical and clinical applications.
Ullman, Edwin F. J. Chem. Educ. 1999, 76, 781.
Biotechnology |
Enzymes |
Atomic Properties / Structure |
Free Radicals |
Photochemistry |
Medicinal Chemistry |
Proteins / Peptides
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Nucleophilic and Enzymic Catalysis of p-Nitrophenylacetate Hydrolysis Head, Michael B.; Mistry, Kalpna S.; Ridings, Bernard J.; Smith, Christopher A.; Parker, Mark J.
Experimental procedure for determining the relative effectiveness of several amino acids and enzymes in catalyzing the hydrolysis of p-nitrophenylacetate; sample data and analysis included.
Head, Michael B.; Mistry, Kalpna S.; Ridings, Bernard J.; Smith, Christopher A.; Parker, Mark J. J. Chem. Educ. 1995, 72, 184.
Amino Acids |
Enzymes |
Proteins / Peptides |
Catalysis
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A Ligand-Binding Study Based on a Protein Assay Method Chial, H. J.; Congdon, R. W.; Splittgerber, A. G.
Experimental procedure for determining the protein concentration of an unknown solution, as well as the number of dye-binding sites on the protein; data and analysis included.
Chial, H. J.; Congdon, R. W.; Splittgerber, A. G. J. Chem. Educ. 1995, 72, 76.
Proteins / Peptides |
Coordination Compounds |
Crystal Field / Ligand Field Theory
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Identification of amino acids in unknown dipeptides: A derivatization with 9-fluorenylmethyl chloroformate and HPLC Clapp, Charles H.; Swan, James S.; Poechmann, James L.
This paper describes a biochemistry experiment in which students use HPLC to identify the amino acids in unknown dipeptides.
Clapp, Charles H.; Swan, James S.; Poechmann, James L. J. Chem. Educ. 1992, 69, A122.
Amino Acids |
Proteins / Peptides |
HPLC
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Teaching bioorganic chemistry: An introductory course Dugas, Hermann
Bioorganic chemistry could be defined as a discipline that is essentially concerned with using the tools of organic chemistry to understand biochemical processes.
Dugas, Hermann J. Chem. Educ. 1992, 69, 268.
Bioorganic Chemistry |
Catalysis |
Biological Cells |
Proteins / Peptides |
Medicinal Chemistry
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A convenient synthesis of aspartame Lindeberg, Gunnar
The one tube, enzymatic synthesis of the dipeptide sweetener aspartame.
Lindeberg, Gunnar J. Chem. Educ. 1987, 64, 1062.
Synthesis |
Enzymes |
Proteins / Peptides
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Perspectives in biochemistry: Methods for DNA sequencing Wood, Anne T.
Describes how DNA is sequenced.
Wood, Anne T. J. Chem. Educ. 1984, 61, 886.
Proteins / Peptides |
Biotechnology |
Electrophoresis
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Isoenzymes Daugherty, N. A.
The separation, identification, and measurement of isoenzymes is an appropriate topic for a special lecture in general chemistry.
Daugherty, N. A. J. Chem. Educ. 1979, 56, 442.
Enzymes |
Proteins / Peptides |
pH |
Electrophoresis |
Separation Science |
Electrochemistry |
Applications of Chemistry
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The separation of chymotrypsin and chymotrypsinogen: An affinity chromatography experiment for biological chemistry students Branchini, Bruce; Ziolkowski, Rodney
An experiment that can be used as either a demonstration or a laboratory illustrating the principles of affinity chromatography to purify an enzyme.
Branchini, Bruce; Ziolkowski, Rodney J. Chem. Educ. 1979, 56, 281.
Separation Science |
Chromatography |
Proteins / Peptides
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Bromolain. Experiments illustrating proteolytic enzyme action Reigh, Darryel L.
The following set of exercises provides a simple visual method of demonstrations some of the characteristics of enzymes in general, such as heat and pH lability and inhibition, as well as some specific properties of bromelain intide hydrolysis. These experiments can be used with freshman in introductory courses and juniors in biochemistry.
Reigh, Darryel L. J. Chem. Educ. 1976, 53, 386.
Enzymes |
pH |
Food Science |
Natural Products |
Proteins / Peptides
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Allied health chemistry laboratory. Amino acids, insulin, proteins, and skin Dever, David F.
Describes an allied health chemistry laboratory involving amino acids, insulin, proteins and skin that begins with the construction of molecular models of amino acids and proteins.
Dever, David F. J. Chem. Educ. 1975, 52, 338.
Amino Acids |
Proteins / Peptides |
Medicinal Chemistry |
Nonmajor Courses |
Molecular Properties / Structure |
Molecular Modeling |
Applications of Chemistry
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Photochemical reactions of natural macromolecules. Photoreactions of proteins Neckers, Douglas C.
Reviews salient features of protein destruction by ultraviolet radiation.
Neckers, Douglas C. J. Chem. Educ. 1973, 50, 164.
Photochemistry |
Proteins / Peptides |
Amino Acids
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Simple method for demonstrating an enzymatic reaction Tang, Chung-Shih
Uses taste sensations of papaya seeds under varying conditions to demonstrate an enzymatic reaction.
Tang, Chung-Shih J. Chem. Educ. 1970, 47, 692.
Enzymes |
Proteins / Peptides |
Food Science |
Reactions |
Consumer Chemistry |
Applications of Chemistry
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Preparation of the proteins by micro-organisms Dieteren, H. M. L.; Schouteten, A. P. H.
Yeast are used to generate proteins from tetradecane in a controlled vessel.
Dieteren, H. M. L.; Schouteten, A. P. H. J. Chem. Educ. 1970, 47, 663.
Proteins / Peptides |
Synthesis
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Schematic models of biochemical polymers Blackwell, R. Quentin
Demonstrates the use of plastic necklace beads to represent polysaccharides, peptides and proteins, and nucleotides.
Blackwell, R. Quentin J. Chem. Educ. 1957, 34, 500.
Molecular Modeling |
Molecular Properties / Structure |
Proteins / Peptides |
Carbohydrates
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