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Journal Articles: 45 results
The A1c Blood Test: An Illustration of Principles from General and Organic Chemistry  Robert C. Kerber
The glycated hemoglobin blood test is a key measure of the effectiveness of glucose control in diabetics. The chemistry of glucose in the bloodstream, which underlies the test and its impact, provides an illustration of the importance of chemical equilibrium and kinetics to a major health problem.
Kerber, Robert C. . J. Chem. Educ. 2007, 84, 1541.
Applications of Chemistry |
Bioinorganic Chemistry |
Carbohydrates |
Mechanisms of Reactions |
Proteins / Peptides |
Bioorganic Chemistry
Nature's Way To Make the Lantibiotics  Heather A. Relyea and Wilfred A. van der Donk
This article focuses on one class of antimicrobial compounds, the lantibiotics, and discusses their biosynthetic pathways as well as their molecular mode of action. In the course of the review, the meaning of the terms regio-, chemo-, and stereoselectivity are discussed.
Relyea, Heather A.; van der Donk, Wilfred A. J. Chem. Educ. 2006, 83, 1769.
Applications of Chemistry |
Bioorganic Chemistry |
Biotechnology |
Biosynthesis |
Catalysis |
Drugs / Pharmaceuticals |
Proteins / Peptides
Caught on Tape: Catalyst Recovery; Secondary Structure Switch; DNA-Based Chiral Catalysts   Angela G. King
Common lab tape aids catalyst delivery and recovery, DNA lends its chirality to organic reaction, and a model for studying the transformation of ahelices to ?sheets.
King, Angela G. J. Chem. Educ. 2006, 83, 10.
Catalysis |
Chirality / Optical Activity |
Proteins / Peptides |
Molecular Modeling |
Molecular Properties / Structure
A Supramolecular Approach to Medicinal Chemistry: Medicine Beyond the Molecule  David K. Smith
This article emphasizes a conceptual view of medicinal chemistry, which has important implications for the future, as the supramolecular approach to medicinal-chemistry products outlined here is rapidly allowing nanotechnology to converge with medicine. In particular, this article discusses recent developments including the rational design of drugs such as Relenza and Tamiflu, the mode of action of vancomycin, and the mechanism by which bacteria develop resistance, drug delivery using cyclodextrins, and the importance of supramolecular chemistry in understanding protein aggregation diseases such as Alzheimer's and CreutzfieldJacob.
Smith, David K. J. Chem. Educ. 2005, 82, 393.
Drugs / Pharmaceuticals |
Noncovalent Interactions |
Medicinal Chemistry |
Nanotechnology |
Proteins / Peptides
The Proteomics Stock Market Project. A Cross-Disciplinary Collaboration in Biochemistry and Business Education  Heath Keller and James R. Cox
Students taking courses in different disciplines can work together to add unique elements to their educational experience. Stage I involved biochemistry students investigating the topic of proteomics and choosing companies for potential investment based only on scientific investigation. Marketing and management students completed Stage II and provided an investment analysis on the companies selected in Stage I.
Keller, Heath; Cox, James R. J. Chem. Educ. 2004, 81, 519.
Drugs / Pharmaceuticals |
Proteins / Peptides
Protein Design Using Unnatural Amino Acids  Basar Bilgiçer and Krishna Kumar
Using examples from the literature, this article describes the available methods for unnatural amino acid incorporation and highlights some recent applications including the design of hyperstable protein folds.
Bilgiçer, Basar; Kumar, Krishna. J. Chem. Educ. 2003, 80, 1275.
Amino Acids |
Bioorganic Chemistry |
Biotechnology |
Proteins / Peptides |
Synthesis |
Molecular Properties / Structure
Identifying a Protein by MALDI–TOF Mass Spectrometry: An Experiment for the Undergraduate Laboratory  Anne E. Counterman, Matthew S. Thompson, and David E. Clemmer
Experiment that requires students to use mass spectral data (MALDI-TOF) to find the identity of an unknown protein sample by performing a database search on the Internet.
Counterman, Anne E.; Thompson, Matthew S.; Clemmer, David E. J. Chem. Educ. 2003, 80, 177.
Mass Spectrometry |
Proteins / Peptides |
Instrumental Methods |
Qualitative Analysis
Entropy Loss of Hydroxyl Groups of Balanol upon Binding to Protein Kinase A  Gergely Gidofalvi, Chung F. Wong, and J. Andrew McCammon
Summer project to give undergraduates hands-on experience in using several modern tools of molecular modeling for computer-aided drug design.
Gidofalvi, Gergely; Wong, Chung F.; McCammon, J. Andrew. J. Chem. Educ. 2002, 79, 1122.
Computational Chemistry |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Molecular Recognition |
Undergraduate Research |
Molecular Modeling |
Statistical Mechanics |
Thermodynamics |
Proteins / Peptides
Blood-Chemistry Tutorials: Teaching Biological Applications of General Chemistry Material  Rachel E. Casiday, Dewey Holten, Richard Krathen, and Regina F. Frey
Four, Web-based tutorials that deal with chemical processes in the blood and provide an integrated biological context for a variety of chemical concepts.
Casiday, Rachel E.; Holten, Dewey; Krathen, Richard; Frey, Regina F. J. Chem. Educ. 2001, 78, 1210.
Applications of Chemistry |
Medicinal Chemistry |
Proteins / Peptides |
Acids / Bases |
Equilibrium |
Molecular Properties / Structure
Protein Structure Wordsearch  Terry L. Helser
Puzzle with 37 names, terms, prefixes, and acronyms that describe protein structure.
Helser, Terry L. J. Chem. Educ. 2001, 78, 474.
Proteins / Peptides |
Nomenclature / Units / Symbols |
Molecular Properties / Structure
Homogeneous Immunoassays: Historical Perspective and Future Promise  Edwin F. Ullman
The founding and growth of Syva Company is examined in the context of its leadership role in the development of homogeneous immunoassays. The simple mix and read protocols of these methods offer advantages in routine analytical and clinical applications.
Ullman, Edwin F. J. Chem. Educ. 1999, 76, 781.
Biotechnology |
Enzymes |
Atomic Properties / Structure |
Free Radicals |
Photochemistry |
Medicinal Chemistry |
Proteins / Peptides
Molecular Mechanics across Chemistry (by Anthony K. Rapp and Carla J. Casewit)  G. Craig Hill
The text is divided into 8 chapters, beginning with an Overview, followed by Organics, Peptides and Proteins, Drug Design, DNA, Synthetic Polymers, Inorganics, and Force Fields.
Hill, G. Craig. J. Chem. Educ. 1999, 76, 325.
Proteins / Peptides |
Drugs / Pharmaceuticals
A Ligand-Binding Study Based on a Protein Assay Method  Chial, H. J.; Congdon, R. W.; Splittgerber, A. G.
Experimental procedure for determining the protein concentration of an unknown solution, as well as the number of dye-binding sites on the protein; data and analysis included.
Chial, H. J.; Congdon, R. W.; Splittgerber, A. G. J. Chem. Educ. 1995, 72, 76.
Proteins / Peptides |
Coordination Compounds |
Crystal Field / Ligand Field Theory
Use of Tangle Links To Show Globular Protein Structure  Marino, Francis
Using Tangle Links (a child's toy) to model the primary, secondary, tertiary, and quaternary structure of proteins.
Marino, Francis J. Chem. Educ. 1994, 71, 741.
Proteins / Peptides |
Molecular Modeling
An inexpensive gel-filtration chromatography experiment: A simple biochemical laboratory exercise for high school and undergraduate students who make their own column and apply simple detection techniques  Rowe, H. Alan
The experiment described in this paper can be conducted with a minimum of supplies and equipment at the high school or undergraduate level thus lowering the usual barriers an exercise of this type presents.
Rowe, H. Alan J. Chem. Educ. 1993, 70, 415.
Chromatography |
Bioorganic Chemistry |
Laboratory Equipment / Apparatus |
Carbohydrates |
Proteins / Peptides
Identification of amino acids in unknown dipeptides: A derivatization with 9-fluorenylmethyl chloroformate and HPLC   Clapp, Charles H.; Swan, James S.; Poechmann, James L.
This paper describes a biochemistry experiment in which students use HPLC to identify the amino acids in unknown dipeptides.
Clapp, Charles H.; Swan, James S.; Poechmann, James L. J. Chem. Educ. 1992, 69, A122.
Amino Acids |
Proteins / Peptides |
HPLC
Monitoring self-association of a hydrophobic peptide with high performance liquid chromatography: An undergraduate kinetic experiment using the antibiotic gramicidin A  Braco, Lorenzo; Ba, M. Carmen; Abad, Concepcin
The authors propose a kinetic experiment that uses high performance liquid chromatography to determine the rate and equilibrium constants in a very simple manner, and separate the molecular species under study.
Braco, Lorenzo; Ba, M. Carmen; Abad, Concepcin J. Chem. Educ. 1992, 69, A113.
HPLC |
Kinetics |
Proteins / Peptides |
Rate Law |
Equilibrium
Inclass interactive worksheets for organic chemistry  Ostercamp, Daryl L.
The author has designed two in-class worksheets for use near the end of a two semester organic chemistry course, one dealing with mono- and disaccharides and the second dealing with alpha-amino acids and dipeptides.
Ostercamp, Daryl L. J. Chem. Educ. 1992, 69, 318.
Carbohydrates |
Amino Acids |
Proteins / Peptides
Teaching bioorganic chemistry: An introductory course  Dugas, Hermann
Bioorganic chemistry could be defined as a discipline that is essentially concerned with using the tools of organic chemistry to understand biochemical processes.
Dugas, Hermann J. Chem. Educ. 1992, 69, 268.
Bioorganic Chemistry |
Catalysis |
Biological Cells |
Proteins / Peptides |
Medicinal Chemistry
Isolation of the active site of cytochrome c by reverse-phase high-performance liquid chromatography  Kenigsberg, Paul A.; Blanke, Steven R.; Hager, Lowell P.
To serve as an introduction to research, an advanced-level graduate laboratory course should be challenging, incorporate currently relevant techniques, offer more responsibility to students, and contain a minimum of technical pitfalls. The following experiment meets all the aforementioned criteria.
Kenigsberg, Paul A.; Blanke, Steven R.; Hager, Lowell P. J. Chem. Educ. 1990, 67, 177.
HPLC |
Proteins / Peptides
Synthesis of an enkephalinase inhibitor, Gly-Gly-Phe-Leu, by continuous-flow peptide synthesizer  Iskander, Magdy N.; Jones, Paul A.
The assembly of the continuous flow peptide synthesizer was carried out in the author's laboratory with no difficulty and has generated great interest among their students.
Iskander, Magdy N.; Jones, Paul A. J. Chem. Educ. 1990, 67, 170.
Synthesis |
Proteins / Peptides |
Medicinal Chemistry |
Laboratory Equipment / Apparatus
A game show approach to teaching peptide sequencing  Lemley, Paul V.
The game allows each group of students to propose experiments, report what results would have occurred, interpret results, and propose more experiments.
Lemley, Paul V. J. Chem. Educ. 1989, 66, 1011.
Proteins / Peptides
Microscale synthesis and analysis of a dipeptide  Blatchly, Richard A.; Allen, Timothy R.; Bergstrom, Dirk T.; Shinozaki, Yuji
The synthesis of a dipeptide from its component amino acids and its analysis by chiral-phase thin-layer chromatography.
Blatchly, Richard A.; Allen, Timothy R.; Bergstrom, Dirk T.; Shinozaki, Yuji J. Chem. Educ. 1989, 66, 965.
Microscale Lab |
Synthesis |
Proteins / Peptides |
Thin Layer Chromatography |
Amino Acids
A convenient synthesis of aspartame  Lindeberg, Gunnar
The one tube, enzymatic synthesis of the dipeptide sweetener aspartame.
Lindeberg, Gunnar J. Chem. Educ. 1987, 64, 1062.
Synthesis |
Enzymes |
Proteins / Peptides
Protein structure prediction in color  Davis, Lawrence C.; Radke, Gary A.
84. Implementing the Chuo and Faslar method for prediction of secondary structure and the Kyte and Doolittle method for predicting "hydropathic character" on an Apple IIe computer with color graphics.
Davis, Lawrence C.; Radke, Gary A. J. Chem. Educ. 1987, 64, 582.
Proteins / Peptides |
Molecular Properties / Structure
An inexpensive molecular model  Brickley, Meredith; Silva, R. A.
An inexpensive, space-filling model to help students understand the structure of proteins.
Brickley, Meredith; Silva, R. A. J. Chem. Educ. 1985, 62, 1077.
Molecular Modeling |
Proteins / Peptides
Use of the "cubic snake" as a molecular model  Gilon, Chaim
Using a "cubic snake" to model macromolecules.
Gilon, Chaim J. Chem. Educ. 1985, 62, 1074.
Molecular Modeling |
Molecular Properties / Structure |
Proteins / Peptides |
Enzymes
The catalytic function of enzymes  Splittgerber, Allan G.
Review of the structure, function, and factors that influence the action of enzymes.
Splittgerber, Allan G. J. Chem. Educ. 1985, 62, 1008.
Catalysis |
Enzymes |
Mechanisms of Reactions |
Proteins / Peptides |
Molecular Properties / Structure
Zinc enzymes  Bertini, I.; Luchinat, C.; Monnanni, R.
The role played by catalytic and noncatalytic zinc in biochemical systems. From the "State of the Art Symposium: Bioinorganic Chemistry", held at the ACS meeting, Miami, 1985.
Bertini, I.; Luchinat, C.; Monnanni, R. J. Chem. Educ. 1985, 62, 924.
Enzymes |
Bioinorganic Chemistry |
Lewis Acids / Bases |
Proteins / Peptides
Perspectives in biochemistry: Methods for DNA sequencing  Wood, Anne T.
Describes how DNA is sequenced.
Wood, Anne T. J. Chem. Educ. 1984, 61, 886.
Proteins / Peptides |
Biotechnology |
Electrophoresis
The synthesis of a dipeptide from its component amino acids: Protecting groups in the elementary organic laboratory  Young, Paul E.; Campbell, Andrew
A three-step procedure for synthesizing a dipeptide from its component amino acids.
Young, Paul E.; Campbell, Andrew J. Chem. Educ. 1982, 59, 701.
Synthesis |
Amino Acids |
Proteins / Peptides
Protein denaturation: A physical chemistry project lab  Pickering, Miles; Crabtree, Robert H.
This experiment links physical chemistry with biology and can be done with in advanced freshman course.
Pickering, Miles; Crabtree, Robert H. J. Chem. Educ. 1981, 58, 513.
Proteins / Peptides |
Biophysical Chemistry |
Molecular Properties / Structure
Isoenzymes  Daugherty, N. A.
The separation, identification, and measurement of isoenzymes is an appropriate topic for a special lecture in general chemistry.
Daugherty, N. A. J. Chem. Educ. 1979, 56, 442.
Enzymes |
Proteins / Peptides |
pH |
Electrophoresis |
Separation Science |
Electrochemistry |
Applications of Chemistry
Bromolain. Experiments illustrating proteolytic enzyme action  Reigh, Darryel L.
The following set of exercises provides a simple visual method of demonstrations some of the characteristics of enzymes in general, such as heat and pH lability and inhibition, as well as some specific properties of bromelain intide hydrolysis. These experiments can be used with freshman in introductory courses and juniors in biochemistry.
Reigh, Darryel L. J. Chem. Educ. 1976, 53, 386.
Enzymes |
pH |
Food Science |
Natural Products |
Proteins / Peptides
Non-covalent interactions: Key to biological flexibility and specificity  Frieden, Earl
Summarizes the types of non-covalent interactions found among biomolecules and how they facilitate the function of antibodies, hormones, and hemoglobin.
Frieden, Earl J. Chem. Educ. 1975, 52, 754.
Noncovalent Interactions |
Hydrogen Bonding |
Water / Water Chemistry |
Proteins / Peptides |
Amino Acids |
Molecular Properties / Structure |
Hormones
Allied health chemistry laboratory. Amino acids, insulin, proteins, and skin  Dever, David F.
Describes an allied health chemistry laboratory involving amino acids, insulin, proteins and skin that begins with the construction of molecular models of amino acids and proteins.
Dever, David F. J. Chem. Educ. 1975, 52, 338.
Amino Acids |
Proteins / Peptides |
Medicinal Chemistry |
Nonmajor Courses |
Molecular Properties / Structure |
Molecular Modeling |
Applications of Chemistry
Photochemical reactions of natural macromolecules. Photoreactions of proteins  Neckers, Douglas C.
Reviews salient features of protein destruction by ultraviolet radiation.
Neckers, Douglas C. J. Chem. Educ. 1973, 50, 164.
Photochemistry |
Proteins / Peptides |
Amino Acids
Sickle-cell anemia, hemoglobin solubility and resistance to malaria  Martin, David L.; Huheey, James E.
The phenomenon of erythrocytic sickling is of considerable pedagogical usefulness since it provides a bridge of relevance between chemistry and biology.
Martin, David L.; Huheey, James E. J. Chem. Educ. 1972, 49, 177.
Proteins / Peptides |
Medicinal Chemistry |
Applications of Chemistry
Models for tertiary structures: Myoglobin and lysozyme  Smith, Ivor; Smith, Margaret J.; Roberts, Lynne
Presents the design details for constructing three dimensional models of proteins, including myoglobin and lysozyme.
Smith, Ivor; Smith, Margaret J.; Roberts, Lynne J. Chem. Educ. 1970, 47, 302.
Molecular Properties / Structure |
Molecular Modeling |
Proteins / Peptides |
Hydrogen Bonding |
Noncovalent Interactions
Polyethylene and pipecleaner models of biological polymers  Pollard, Harvey Bruce
An accurate method for modeling polysaccharides, nucleic acids, and proteins involves the use of pipecleaners, polyethylene tubing, and proteins.
Pollard, Harvey Bruce J. Chem. Educ. 1966, 43, 327.
Proteins / Peptides |
Molecular Modeling |
Molecular Properties / Structure |
Carbohydrates
Models illustrating the helix-coil transition in polypeptides  Hayman, H. J. G.
Describes modifications of the Fisher-Hirschfelder-Taylor atom models whereby a model of a polypeptide molecule in the form of a random chain can easily be rolled up to give the alpha-helix configuration and then unrolled again to give once more a random chain.
Hayman, H. J. G. J. Chem. Educ. 1964, 41, 561.
Molecular Modeling |
Molecular Properties / Structure |
Proteins / Peptides
Ribonucleic acid: The simplest information-transmitting molecule  Fraenkel-Conrat, H.
Examines the chemical structure of nucleic acids, chemical modification of RNA and mutagenesis, role of RNA in protein structure, the mechanism of information transfer from RNA to protein, and mutants and coding.
Fraenkel-Conrat, H. J. Chem. Educ. 1963, 40, 216.
Proteins / Peptides
Identification of amino acids in a protein hydrolysate by paper chromatography  Clapp, L. B.; Hansch, Corwin
By varying the number of amino acids to be identified, the difficulty of this procedure can be easily controlled.
Clapp, L. B.; Hansch, Corwin J. Chem. Educ. 1960, 37, 293.
Amino Acids |
Qualitative Analysis |
Proteins / Peptides |
Chromatography
The geometry of giant molecules  Price, Charles C.
The author examines a variety of specific examples of natural and synthetic polymer molecules and describes how their geometric molecular arrangements influence their properties.
Price, Charles C. J. Chem. Educ. 1959, 36, 160.
Molecular Properties / Structure |
Proteins / Peptides |
Carbohydrates
Schematic models of biochemical polymers  Blackwell, R. Quentin
Demonstrates the use of plastic necklace beads to represent polysaccharides, peptides and proteins, and nucleotides.
Blackwell, R. Quentin J. Chem. Educ. 1957, 34, 500.
Molecular Modeling |
Molecular Properties / Structure |
Proteins / Peptides |
Carbohydrates