TIGER

Journal Articles: 71 results
Molecules and Medicine (E. J. Corey, Barbara Czakó, and László Kürti)  Robert E. Buntrock
Looking for a book on common drugs and pharmaceuticals? On diseases and medical conditions? On pharmacology? In addition, do you need some background in chemistry to handle all of this information? If you want all of this, and in addition want it under one cover, then this is the book for you.
Buntrock, Robert E. J. Chem. Educ. 2008, 85, 1495.
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Molecular Properties / Structure |
Proteins / Peptides |
Synthesis |
Toxicology
Frank Westheimer's Early Demonstration of Enzymatic Specificity  Addison Ault
Reviews one of the most significant accomplishments of one of the most respected chemists of the 20th centurya series of stereospecific enzymatic oxidation and reduction experiments that led chemists to recognize enantiotopic and diastereotopic relationships of atoms, or groups of atoms, within molecules.
Ault, Addison. J. Chem. Educ. 2008, 85, 1246.
Asymmetric Synthesis |
Bioorganic Chemistry |
Catalysis |
Chirality / Optical Activity |
Enantiomers |
Enzymes |
Isotopes |
Nucleophilic Substitution |
Oxidation / Reduction |
Stereochemistry
"As Simple as Possible, but Not Simpler"—The Case of Dehydroascorbic Acid  Robert C. Kerber
Textbooks routinely assign dehydroascorbic acid a tricarbonyl structure that is highly improbable in aqueous solution and inconsistent with its colorless appearance. Studies of oxidized forms of ascorbic acid are summarized here, and a plea is entered for accurate descriptions of chemical structures in this and other cases, even at the cost of some simplicity.
Kerber, Robert C. J. Chem. Educ. 2008, 85, 1237.
Bioorganic Chemistry |
Free Radicals |
Natural Products |
NMR Spectroscopy |
Vitamins
Six Pillars of Organic Chemistry  Joseph J. Mullins
This article focuses on a core set of conceptselectronegativity, polar covalent bonding, inductive and steric effects, resonance, and aromaticitythe proper application of which can explain and predict a wide variety of chemical, physical, and biological properties of molecules and conceptually unite important features of general, organic, and biochemistry.
Mullins, Joseph J. J. Chem. Educ. 2008, 85, 83.
Bioorganic Chemistry |
Covalent Bonding |
Hydrogen Bonding |
Mechanisms of Reactions |
Periodicity / Periodic Table |
Reactive Intermediates |
Resonance Theory
Synthesis of Quaternary Ammonium Salts of Tricyclic Cationic Drugs: A One-Pot Synthesis for the Bioorganic Chemistry Laboratory  Linda S. Brunauer, Abid C. Mogannam, Won B. Hwee, and James Y. Chen
Describes a one-pot conversion of tricyclic cationic drugs to their quaternary ammonium forms for a widely used bioactive drug, chlorpromazine, a phenothiazine-based antipsychotic. The conversion of parent drug to the methylated form was evaluated by qualitatively measuring its ability to induce alterations in the shape of mammalian erythrocytes.
Brunauer, Linda S.; Mogannam, Abid C.; Hwee, Won B.; Chen, James Y. J. Chem. Educ. 2007, 84, 1992.
Amines / Ammonium Compounds |
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
IR Spectroscopy |
Microscale Lab |
NMR Spectroscopy |
Synthesis |
Thin Layer Chromatography
Structures for the ABO(H) Blood Group: Which Textbook Is Correct?  John M. Risley
Six textbooks and two Internet sites show different structures for the A, B, and O(H) antigens of the ABO(H) blood group, but none of them are correct. This article emphasizes the correct molecular structures because it is important to distinguish between those carbohydrates that make up the antigens and those that are not part of the antigenic structures.
Risley, John M. J. Chem. Educ. 2007, 84, 1546.
Bioorganic Chemistry |
Carbohydrates |
Natural Products |
Molecular Properties / Structure
The A1c Blood Test: An Illustration of Principles from General and Organic Chemistry  Robert C. Kerber
The glycated hemoglobin blood test is a key measure of the effectiveness of glucose control in diabetics. The chemistry of glucose in the bloodstream, which underlies the test and its impact, provides an illustration of the importance of chemical equilibrium and kinetics to a major health problem.
Kerber, Robert C. . J. Chem. Educ. 2007, 84, 1541.
Applications of Chemistry |
Bioinorganic Chemistry |
Carbohydrates |
Mechanisms of Reactions |
Proteins / Peptides |
Bioorganic Chemistry
Synthesis of Plant Auxin Derivatives and Their Effects on Ceratopteris richardii  Corey E. Stilts and Roxanne Fisher
In this experiment, organic chemistry students synthesize derivatives of their own design of the plant auxins indole-3-acetic acid and 1-naphthalene acetic acid. Biochemistrycell biology students then examine the development of Ceratopteris richardii gametophytes on medium containing auxin derivatives synthesized in the organic chemistry lab.
Stilts, Corey E.; Fisher, Roxanne. J. Chem. Educ. 2007, 84, 999.
Biological Cells |
Bioorganic Chemistry |
Hormones |
Synthesis
Receptor Surface Models in the Classroom: Introducing Molecular Modeling to Students in a 3-D World  Werner J. Geldenhuys, Michael Hayes, Cornelis J. Van der Schyf, David D. Allen, and Sarel F. Malan
Proposes a novel method for teaching drug interactions with a receptor, enzyme, or any other macromolecule or protein using plastic molecular models and aluminum foil.
Geldenhuys, Werner J.; Hayes, Michael; Van der Schyf, Cornelis J.; Allen, David D.; Malan, Sarel F. J. Chem. Educ. 2007, 84, 979.
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Laboratory Computing / Interfacing |
Medicinal Chemistry |
Molecular Modeling |
Enzymes
Chemical Aspects of General Anesthesia: Part II. Current Practices  Robert Brunsvold and Daryl L. Ostercamp
With the basic elements of balanced general anesthesia in place by the 1950s, the focus turned to developing safer and more effective agents and to improving procedures. During the last half-century a new generation of intravenous induction anesthetics, inhalational anesthetics, and muscle relaxants has emerged.
Brunsvold, Robert; Ostercamp, Daryl L. J. Chem. Educ. 2006, 83, 1826.
Bioorganic Chemistry |
Chirality / Optical Activity |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Synthesis
Chemical Aspects of General Anesthesia: Part I. From Ether to Halothane  Robert Brunsvold and Daryl L. Ostercamp
Summarizes general anesthesia from 1846 to 1956. Events leading up to the adoption of a "balanced" approach, where a sequence of individual compounds is used rather than a single agent, are described.
Brunsvold, Robert; Ostercamp, Daryl L. J. Chem. Educ. 2006, 83, 1821.
Acids / Bases |
Bioorganic Chemistry |
Chirality / Optical Activity |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Synthesis
Chemical Aspects of Local and Regional Anesthesia  Robert Brunsvold and Daryl L. Ostercamp
The chemistry that underlies the development of local and regional anesthesia is explored. Emphasis is placed upon the importance of acidity constants and lipophilic versus hydrophilic character in interpreting what affect a particular compound has upon biological processes.
Brunsvold, Robert; Ostercamp, Daryl L. J. Chem. Educ. 2006, 83, 1816.
Acids / Bases |
Bioorganic Chemistry |
Chirality / Optical Activity |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Synthesis |
Applications of Chemistry
Capsaicin, from Hot to Not; Can New Pain-Relieving Drugs Be Derived from This Substance Known To Cause Pain?  David B. Rusterholz
This article traces the development of modified capsaicin structures that offer improved analgesic effectiveness with minimal pungency and the discovery of compounds that act as antagonists at the TRPV1 receptor, which appear to hold promise as new drugs that will be useful for the treatment of some types of pain.
Rusterholz, David B. J. Chem. Educ. 2006, 83, 1809.
Applications of Chemistry |
Bioorganic Chemistry |
Biosignaling |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Molecular Recognition
Nature's Way To Make the Lantibiotics  Heather A. Relyea and Wilfred A. van der Donk
This article focuses on one class of antimicrobial compounds, the lantibiotics, and discusses their biosynthetic pathways as well as their molecular mode of action. In the course of the review, the meaning of the terms regio-, chemo-, and stereoselectivity are discussed.
Relyea, Heather A.; van der Donk, Wilfred A. J. Chem. Educ. 2006, 83, 1769.
Applications of Chemistry |
Bioorganic Chemistry |
Biotechnology |
Biosynthesis |
Catalysis |
Drugs / Pharmaceuticals |
Proteins / Peptides
Molecular Model of Creatine Synthesis  William F. Coleman
The Featured Molecules for this month come from the synthesis of creatine and illustrate some of the limitations associated with the computation of molecular structure.
Coleman, William F. J. Chem. Educ. 2006, 83, 1657.
Molecular Modeling |
Molecular Properties / Structure |
Bioorganic Chemistry
Creatine Synthesis: An Undergraduate Organic Chemistry Laboratory Experiment  Andri L. Smith and Paula Tan
Describes the synthesis of creatine monohydratea popular supplement used in sports requiring short bursts of energyfor introductory organic chemistry laboratory courses. The synthesis illustrates the electrophilic nature of nitriles, as well as the nucleophilic nature of amines.
Smith, Andri L.; Tan, Paula. J. Chem. Educ. 2006, 83, 1654.
Amines / Ammonium Compounds |
Aqueous Solution Chemistry |
Bioorganic Chemistry |
Chromatography |
Dyes / Pigments |
Mechanisms of Reactions |
Microscale Lab |
Thin Layer Chromatography
Teaching Biologically Relevant Chemistry throughout the Four-Year Chemistry Curriculum  Sarah R. Kirk, Todd P. Silverstein, and Jeffrey J. Willemsen
First-year chemistry students learn introductory chemistry using case studies which deal directly with human health issues and biological processes. Second-year students choose between two equivalent versions of the second-semester course: one that stresses synthetic organic chemistry and another that stresses bioorganic chemistry.
Kirk, Sarah R.; Silverstein, Todd P.; Willemsen, Jeffrey J. J. Chem. Educ. 2006, 83, 1171.
Bioorganic Chemistry |
Bioenergetics
Computer-Based Conformational Analysis of Acetylcholine and Muscarine Combined with an Overview of the Receptor–Ligand Interaction   Marcelo Tavares de Oliveira, Minéia Alves dos Santos, and Thais Horta Álvares da Silva
Reports on a procedure to perform conformational analysis using the systematic search method and the superimposition of two bioactive molecules, acetylcholine and muscarine. The undergraduate students individually perform the proposed procedure using a personal computer.
Tavares de Oliveira, Marcelo; Alves dos Santos, Minéia ; Álvares da Silva, Thais Horta. J. Chem. Educ. 2006, 83, 780.
Bioorganic Chemistry |
Computational Chemistry |
Conformational Analysis |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Molecular Mechanics / Dynamics |
Molecular Modeling |
Molecular Properties / Structure |
Receptors
The Discovery and Development of Cisplatin  Rebecca A. Alderden, Matthew D. Hall, and Trevor W. Hambley
Cisplatin is currently one of the most widely used anticancer drugs in the world. The unlikely events surrounding the discovery of its anticancer activity, subsequent introduction into the clinic, and the continuing research into platinum compounds is the subject of this review.
Alderden, Rebecca A.; Hall, Matthew D.; Hambley, Trevor W. J. Chem. Educ. 2006, 83, 728.
Bioinorganic Chemistry |
Coordination Compounds |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Metallic Bonding |
Oxidation State |
Synthesis
Calcium Phosphates and Human Beings  Sergey V. Dorozhkin
This article describes the general importance of calcium phosphates for human beings. The basic information on the structure and chemical properties of the biologically relevant calcium phosphates is summarized.
Dorozhkin, Sergey V. J. Chem. Educ. 2006, 83, 713.
Applications of Chemistry |
Bioinorganic Chemistry |
Biotechnology |
Materials Science |
Medicinal Chemistry |
Natural Products
Glycosyltransferases A and B: Four Critical Amino Acids Determine Blood Type  Natisha L. Rose, Monica M. Palcic, and Stephen V. Evans
Human A, B, and O blood type is determined by the presence or absence of distinct carbohydrate structures on red blood cells. In this review the chemistry of the blood group ABO system and the role of glycosyltransferase A, glycosyltransferase B, and the four amino acids critical to determining blood group status are discussed.
Rose, Natisha L.; Palcic, Monica M.; Evans, Stephen V. J. Chem. Educ. 2005, 82, 1846.
Carbohydrates |
Enzymes |
Kinetics |
Bioorganic Chemistry |
Crystals / Crystallography |
Molecular Biology |
X-ray Crystallography |
Amino Acids
Organic Chemistry of the Cell: An Interdisciplinary Approach To Learning with a Focus on Reading, Analyzing, and Critiquing Primary Literature  Craig A. Almeida and Louis J. Liotta
Describes a sophomore-level learning community entitled Organic Chemistry of the Cell comprised of two linked courses, Organic Chemistry I and Cell Biology, and an Integrative Seminar. The Integrative Seminar is grounded in the reading, critical analysis, and discussion of primary literature that ties together organic chemistry and cell biology.
Almeida, Craig A.; Liotta, Louis J. J. Chem. Educ. 2005, 82, 1794.
Biological Cells |
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Enzymes |
Molecular Biology |
Student-Centered Learning
Polypyrazolylborates: Scorpionates  Swiatoslaw Trofimenko
Key features of polypyrazolylborates (also known as scorpionates because of certain specific features of their coordination chemistry) and examples of their use in modeling biologically active compounds are briefly presented.
Trofimenko, Swiatoslaw. J. Chem. Educ. 2005, 82, 1715.
Coordination Compounds |
Heterocycles |
Synthesis |
Bioinorganic Chemistry |
Molecular Properties / Structure
Isolation of Shikimic Acid from Star Aniseed  Richard Payne and Michael Edmonds
The isolation of shikimic acid from star aniseed is described. This experiment uses Soxhlet extraction followed by ion exchange chromatography to isolate crude shikimic acid from the star aniseed. Subsequent charcoal decolorization and recrystallization from toluene and methanol afford the pure shikimic acid in 27% w/w yield.
Payne, Richard; Edmonds, Michael. J. Chem. Educ. 2005, 82, 599.
Bioorganic Chemistry |
Natural Products |
NMR Spectroscopy |
Plant Chemistry
Volatile Organic Sulfur Compounds of Environmental Interest: Dimethyl Sulfide and Methanethiol. An Introductory Overview  Thomas G. Chasteen and Ronald Bentley
Volatile organic sulfur compounds and their degradation products play important environmental roles in global warming, acid precipitation, and cloud formation. Two important members of this group, dimethyl sulfide, DMS, and methanethiol, MT, are formed by living organisms as well as by abiotic processes. The chemical reactions responsible for the biosynthesis of DMS and MT are emphasized here, as well as means for their degradation. Since sulfur compounds are often ignored in normal course work, this article provides a basic foundation for an understanding of these interesting and environmentally significant compounds.
Chasteen, Thomas G.; Bentley, Ronald. J. Chem. Educ. 2004, 81, 1524.
Atmospheric Chemistry |
Bioorganic Chemistry |
Gases |
Oxidation / Reduction
Chemical Modification of Papain and Subtilisin: An Active Site Comparison. An Undergraduate Biochemistry Experiment   Mireille St-Vincent and Michael Dickman
This experiment demonstrates the specific chemistry of cysteine and serine residues in the active sites of papain and subtilisin.
St-Vincent, Mireille; Dickman, Michael. J. Chem. Educ. 2004, 81, 1048.
Amino Acids |
Bioorganic Chemistry |
Enzymes
Research Partnership between Teaching-Centered and Research-Intensive Schools  Cristi H. Hunnes and David M. Dooley
This paper describes a model of providing research experiences to undergraduate students by partnering a teaching-centered institution with a research-intensive school.
Hunnes, Cristi H.; Dooley, David M. J. Chem. Educ. 2004, 81, 989.
Undergraduate Research |
Bioorganic Chemistry |
Bioinorganic Chemistry
Free-Energy Relationships in Organic and Bio–Organic Chemistry (Andrew Williams)  Richard Pagni
The book would be a nice supplement to a larger tome used in a senior or graduate level course in organic or physical organic chemistry. It would be an excellent textbook for a specialty course in free energy relationships.
Pagni, Richard. J. Chem. Educ. 2004, 81, 807.
Bioorganic Chemistry
The Trinity of Life: The Genome, the Proteome, and the Mineral Chemical Elements  R. J. P. Williams and J. J. R. Fraústo da Silva
In this article the major changes in evolution from the simplest prokaryote cells to man and his industrial activity are described as a progressive change in the organization of chemistry in spatial compartments.
Williams, R. J. P.; Fraústo da Silva, J. J. R. J. Chem. Educ. 2004, 81, 738.
Bioinorganic Chemistry |
Biophysical Chemistry |
Geochemistry |
Metals |
Transition Elements
Inverting Organic and Biochemistry: A Curriculum Tweak That Benefits All  I. David Reingold
This article makes the case for re-ordering the material currently taught in sophomore organic chemistry and junior biochemistry courses, so that most of the biochemistry appears in the sophomore course and some of the more esoteric organic chemistry material is postponed until junior year.
Reingold, I. David. J. Chem. Educ. 2004, 81, 470.
Administrative Issues |
Bioorganic Chemistry |
Learning Theories
Protein Design Using Unnatural Amino Acids  Basar Bilgiçer and Krishna Kumar
Using examples from the literature, this article describes the available methods for unnatural amino acid incorporation and highlights some recent applications including the design of hyperstable protein folds.
Bilgiçer, Basar; Kumar, Krishna. J. Chem. Educ. 2003, 80, 1275.
Amino Acids |
Bioorganic Chemistry |
Biotechnology |
Proteins / Peptides |
Synthesis |
Molecular Properties / Structure
Bioorganic First: A New Model for the College Chemistry Curriculum  I. David Reingold
Case for making bioorganic chemistry the introductory chemistry course for all college freshmen.
Reingold, I. David. J. Chem. Educ. 2001, 78, 869.
Bioorganic Chemistry
Combinatorial Synthesis and Discovery of an Antibiotic Compound. An Experiment Suitable for High School and Undergraduate Laboratories  Scott E. Wolkenberg and Andrew I. Su
An experiment designed to introduce students to combinatorial chemistry as applied to drug discovery.
Wolkenberg, Scott E.; Su, Andrew I. J. Chem. Educ. 2001, 78, 784.
Aqueous Solution Chemistry |
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Synthesis |
Combinatorial Chemistry |
Applications of Chemistry
A Chemical-Medical Mystery: Gold Jewelry and Black Marks on Skin  Barbara B. Kebbekus
Gold jewelry at times makes a black mark or smudge on skin. This may be caused by abrasive powders on the skin (e.g. zinc oxide) but the phenomenon may also be caused by other skin conditions, possibly the presence of chloride ion, acidity, or sulfur-containing amino acids.
Kebbekus, Barbara B. J. Chem. Educ. 2000, 77, 1298.
Bioorganic Chemistry |
Geochemistry |
Hormones |
Metals |
Solids |
Applications of Chemistry
Two Faces of Alkaloids  Jirí Dostál
The article discusses and compares the salts and free bases of six well-known alkaloids: nicotine, morphine, cocaine, sanguinarine, allocryptopine, and magnoflorine. Relevance for the biological and medical uses of these compounds is emphasized.
Dostál, Jirí. J. Chem. Educ. 2000, 77, 993.
Acids / Bases |
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Natural Products |
Aromatic Compounds |
Medicinal Chemistry
The Other Double Helix--The Fascinating Chemistry of Starch  Robert D. Hancock and Bryon J. Tarbet
The chemistry of starch, particularly the structure of starch and starch granules.
Hancock, Robert D.; Tarbet, Bryon J. J. Chem. Educ. 2000, 77, 988.
Bioorganic Chemistry |
Carbohydrates |
Food Science |
Stereochemistry |
Applications of Chemistry |
Molecular Properties / Structure
Organic Chemistry, 2nd Edition (by Paula Y. Bruice)  Marlene Katz
Bioorganic approach for students interested in the life sciences and in health care fields.
Katz, Marlene. J. Chem. Educ. 1998, 75, 1390.
Bioorganic Chemistry
Kinetic Demonstration of Intermolecular General Acid (GA) Catalysis in Thiolysis of 9-Anilinoacridine   Mohammad Niyaz Khan
After nearly five decades of active research and numerous publications on GA-GB catalysis, introduction of an experiment on GA for students majoring in enzymology/physical organic chemistry at advanced undergraduate/postgraduate level is appropriate. A kinetic experiment involving the reaction of 2-mercaptoethanol (2-ME) with 9-anilinoacridine (9-ANA) is designed to demonstrate intermolecular GA catalysis.
Khan, Mohammad Niyaz. J. Chem. Educ. 1998, 75, 632.
Bioinorganic Chemistry |
Bioorganic Chemistry |
Mechanisms of Reactions |
Catalysis |
Acids / Bases |
Kinetics
Iron as Nutrient and Poison  N. M. Senozan and M. P. Christiano
Iron containing compounds of the body and the ingestion and elimination of iron, the function and transport of this metal among different sites and substances of the body, and biochemical defects and nutritional habits that lead to excessive accumulation of iron and some unexpected consequences of this accumulation are described.
Senozan, N. M.; Christiano, M. P. J. Chem. Educ. 1997, 74, 1060.
Bioinorganic Chemistry |
Bioorganic Chemistry |
Food Science |
Metals |
Vitamins |
Toxicology |
Nutrition |
Applications of Chemistry |
Descriptive Chemistry
Global Metabolism of Elements: Principles and Applications in Bioinorganic Chemistry - XI  Ei-Ichiro Ochiai
The biosphere, as its members metabolize the elements, can thus contribute to the overall global geocycling of elements. A diagram is used to indicate several different manners of the contribution and their extents of contribution to the geoprocesses. This overall process incorporating the effects of the biosphere is termed here as "global metabolism" and is illustrated for iron, mercury and arsenic.
Ochiai, Ei-Ichiro. J. Chem. Educ. 1997, 74, 926.
Bioinorganic Chemistry |
Geochemistry
Book Notes  Arthur Glasfeld
A collection of monographs that are tied together by a common molecular focus on cytochrome c.
Glasfeld, Arthur. J. Chem. Educ. 1997, 74, 496.
Bioinorganic Chemistry |
Biophysical Chemistry
The Manifestation of Evolutionary Pressure in Bioinorganic Chemistry: Principles and Applications in Bioinorganic Chemistry - IX  Ei-Ichiro Ochiai
We know virtually nothing about the evolutionary processes themselves that led to invention of the biocompounds found in the earlier organisms. What we know of is the biomolecules in the organisms presently existing on earth. The only thing we can do then is to rationalize why a biomolecule found in contemporary organisms takes a specific structure and why it behaves the way it does.
Ochiai, Ei-Chiro. J. Chem. Educ. 1997, 74, 348.
Bioinorganic Chemistry
Elements of General, Organic, and Biological Chemistry, Ninth Edition  reviewed by John Ganchoff
The audience for this text includes students in the health sciences (other than physicians) and nonscience students with an interest in the molecular nature of matter. The text can be used for a one-term course and does not have any chemistry prerequisites.
Ganchoff, John. J. Chem. Educ. 1996, 73, A135.
Bioorganic Chemistry |
Nonmajor Courses
The Inorganic Illustrator: A 3-D Graphical Supplement for Inorganic and Bioinorganic Chemistry Courses Distributed on CD-ROM  Scott L. Childs and Karl S. Hagen
As part of this project we are accumulating a database of representative crystal structures of main group molecules, coordination complexes, organometallic compounds, small metalloproteins, bioinorganic model complexes, clusters, and solid state materials in Chem3D Plus format to be viewed with Chem3D Viewer, which is free software from Cambridge Scientific Computing.
Childs, Scott L.; Hagen, Karl S. J. Chem. Educ. 1996, 73, 917.
Molecular Modeling |
Enrichment / Review Materials |
Bioinorganic Chemistry |
Coordination Compounds |
Organometallics |
Main-Group Elements |
Solid State Chemistry
CO, N2, NO, and O2--Their Bioinorganic Chemistry: Principles and Applications in Bioinorganic Chemistry--VIII  Ei-Ichiro Ochiai
The biochemistries of CO2, N2, NO, and O2 are discussed in terms of their basic chemistry.
Ochiai, Ei-Ichiro. J. Chem. Educ. 1996, 73, 130.
Bioinorganic Chemistry |
Atmospheric Chemistry |
Molecular Properties / Structure
Enzymatic Resolution of (+/-)-Menthol Using Transesterification with Methyl (2R)-(+)-2-Chloropropanoate: A Biocatalyzed Reaction Studied by NMR Spectroscopy and Polarimetry for an Advanced Undergraduate Project in Modern Organic Chemistry  C. Poiré, C. Rabiller, C. Chon, and P. Hudhomme
Lipase from Candida rugosa is used as an efficient biocatalyst for the kinetic resolution of (+/-)-Menthol. Methyl (2R)-(+)-2-chloropropanoate is chosen as an acyl donor for the transesterification reaction of menthol.
Poiré, C.; Rabiller, C.; Chon, C.; Hudhomme, P. J. Chem. Educ. 1996, 73, 93.
Bioorganic Chemistry |
Alcohols |
Catalysis |
Enzymes |
NMR Spectroscopy
Bioinorganic Chemistry (Bertini, Ivano; Gray, Harry B.; Lippard, Stephen J.; Valentine, Joan Selverstone)  Kustin, Kenneth
Bioinorganic chemistry text.
Kustin, Kenneth J. Chem. Educ. 1995, 72, A125.
Bioinorganic Chemistry
The Inorganic Illustrator: a 3D Graphical Supplement for Inorganic and Bioinorganic Chemistry Courses Distributed on CDROM  Hagen, Karl S.
Project to develop a variety of manipulatable models, miniature movies, and dynamic animations that address topics in inorganic and bioinorganic chemistry.
Hagen, Karl S. J. Chem. Educ. 1995, 72, 534.
Bioinorganic Chemistry
The microscale separation of lycopene and [beta]-carotene from tomato paste   Goodrich, James; Parker, Chris; Phelps, Ruff
A time effective way to isolate beta-carotene and lycopene from tomato paste on the microscale level.
Goodrich, James; Parker, Chris; Phelps, Ruff J. Chem. Educ. 1993, 70, A158.
Chromatography |
Bioorganic Chemistry |
UV-Vis Spectroscopy |
Quantitative Analysis |
Food Science |
Microscale Lab
Microscale yeast mediated enantiospecific reduction of vanillin, and the absolute configuration of (-)-(R)-[alpha]-deuteriovanillyl alcohol: A bioorganic chemistry experiment   Lee, Moses
An experiment is introduced to a sophomore chemistry course that demonstrates the effeciency and enantiospecificity of microbial/enzyme-mediated reactions and the use of NMR methods in determining the optical activity and absolute configuration of chiral alcohols.
Lee, Moses J. Chem. Educ. 1993, 70, A155.
Enantiomers |
Alcohols |
Bioorganic Chemistry |
Chirality / Optical Activity |
NMR Spectroscopy |
Microscale Lab
An inexpensive gel-filtration chromatography experiment: A simple biochemical laboratory exercise for high school and undergraduate students who make their own column and apply simple detection techniques  Rowe, H. Alan
The experiment described in this paper can be conducted with a minimum of supplies and equipment at the high school or undergraduate level thus lowering the usual barriers an exercise of this type presents.
Rowe, H. Alan J. Chem. Educ. 1993, 70, 415.
Chromatography |
Bioorganic Chemistry |
Laboratory Equipment / Apparatus |
Carbohydrates |
Proteins / Peptides
The preparation of furoin-A biomimetic reaction  Hanson, R. W.
A procedure for the title reaction using a nontoxic analog to cyanide.
Hanson, R. W. J. Chem. Educ. 1993, 70, 257.
Enzymes |
Bioorganic Chemistry |
Catalysis
Determining the critical micelle concentration of aqueous surfactant solutions: Using a novel colorimetric method  Furton, Kenneth G.; Norelus, Arold
Surfactants are versatile chemicals which, at a sufficiently high concentration, will arrange themselves into organized molecular assemblies known as micelles. This paper examines a method for determining this concentration.
Furton, Kenneth G.; Norelus, Arold J. Chem. Educ. 1993, 70, 254.
Micelles |
UV-Vis Spectroscopy |
Bioorganic Chemistry
Biomethylation and environmental transport of metals  Krishnamurthy, S.
Biological methylation of metals is a mechanism that plays an important role in the mobilization and transport of toxic heavy metals.
Krishnamurthy, S. J. Chem. Educ. 1992, 69, 347.
Metals |
Organometallics |
Bioinorganic Chemistry
Teaching bioorganic chemistry: An introductory course  Dugas, Hermann
Bioorganic chemistry could be defined as a discipline that is essentially concerned with using the tools of organic chemistry to understand biochemical processes.
Dugas, Hermann J. Chem. Educ. 1992, 69, 268.
Bioorganic Chemistry |
Catalysis |
Biological Cells |
Proteins / Peptides |
Medicinal Chemistry
The conversion of chemical energy: Part 2. Biochemical examples  Wink, Donald J.
Biological systems regulate energy transfer reactions through enzymes that permit a spontaneous reaction to go faster through a mechanism that also accomplishes work instead of, or in addition to, releasing energy as heat.
Wink, Donald J. J. Chem. Educ. 1992, 69, 264.
Enzymes |
Bioorganic Chemistry |
Bioenergetics
Methods for obtaining the midpoint potential E(m,pH) of a bacterial chromophore.  Rodriguez, Frdric; Prats, Michel.
The authors present a critical analysis of three methods that are used to determine the carotenoid midpoint potential of chromatophores extracted from Rhodobacter capsulatus.
Rodriguez, Frdric; Prats, Michel. J. Chem. Educ. 1992, 69, 245.
Proteins / Peptides |
Photochemistry |
Biological Cells |
Bioorganic Chemistry
Microscale synthesis of cis-diamminedihaloplatinum(II) and a corresponding trans isomer: A rapid and convenient method of preparing cisplatin - An anticancer drug. A laboratory experiment for inorganic and bioinorganic chemistry  Singh, Mono M.; Szafran, Zvi; Pike, Ronald M.
Involves drug synthesis, application of the trans effect, and preparation and characterization of isomers under different reaction conditions.
Singh, Mono M.; Szafran, Zvi; Pike, Ronald M. J. Chem. Educ. 1990, 67, A261.
Microscale Lab |
Synthesis |
Drugs / Pharmaceuticals |
Bioinorganic Chemistry |
Diastereomers
Selective ion transport across biological membranes: A simple experiment in bioinorganic chemistry  Adams, Paul A.; Black, Duncan
In this demonstration the intact human erythrocyte is utilized as a simple model with which to demonstrate the essential features of facilitated anion transport across biological membranes.
Adams, Paul A.; Black, Duncan J. Chem. Educ. 1990, 67, 526.
Bioinorganic Chemistry |
Proteins / Peptides |
Ion Exchange
Azosulfonamides: Preparation and binding to carbonic anhydrase: A bioorganic chemistry experiment  Manalang, Mary G.; Bundy, Hallie F.
Preparation of azosulfonamide, visible absorption analysis of free and enzyme-bond azosulfonamide, and titration of BCA with azosulfonamide.
Manalang, Mary G.; Bundy, Hallie F. J. Chem. Educ. 1989, 66, 609.
Bioorganic Chemistry |
Synthesis |
Proteins / Peptides |
Titration / Volumetric Analysis |
Enzymes
Tomato juice rainbow: A colorful and instructive demonstration  MacBeath, Marie E.; Richardson, Andrew L.
When saturated bromine water is gently stirred into canned tomato juice, a concentration gradient occurs and produces a colorful effect.
MacBeath, Marie E.; Richardson, Andrew L. J. Chem. Educ. 1986, 63, 1092.
Food Science |
Bioorganic Chemistry |
Vitamins
Zinc enzymes  Bertini, I.; Luchinat, C.; Monnanni, R.
The role played by catalytic and noncatalytic zinc in biochemical systems. From the "State of the Art Symposium: Bioinorganic Chemistry", held at the ACS meeting, Miami, 1985.
Bertini, I.; Luchinat, C.; Monnanni, R. J. Chem. Educ. 1985, 62, 924.
Enzymes |
Bioinorganic Chemistry |
Lewis Acids / Bases |
Proteins / Peptides
p-Chlorophenoxyacetic acid-preparation of a synthetic plant hormone  Wood, William F.
Instructions for the preparation of a synthetic plant hormone.
Wood, William F. J. Chem. Educ. 1981, 58, 76.
Plant Chemistry |
Hormones |
Synthesis |
Natural Products |
Bioorganic Chemistry
Bioactivity in organic chemistry courses  Ferguson, Lloyd N.
Considers the antibacterial activity of hydroxy compounds, the carcinogenicity of polycyclic aromatic hydrocarbons, structure-activity correlations, and bioactivity.
Ferguson, Lloyd N. J. Chem. Educ. 1980, 57, 46.
Aromatic Compounds |
Bioorganic Chemistry |
Molecular Properties / Structure
Some aspects of the bioinorganic chemistry of molybdenum  Swedo, Kathleen Bizot; Enemark, John H.
The biological role of molybdenum, biophysical studies of the molybdenum atoms in molybdo-enzymes, and aspects of coordination chemistry that bear on the understanding of molybdo-enzymes.
Swedo, Kathleen Bizot; Enemark, John H. J. Chem. Educ. 1979, 56, 70.
Bioinorganic Chemistry |
Organometallics |
Enzymes |
Coordination Compounds |
Transition Elements
The effect of iodide concentration on the starch-indicator end point in the coulometric determination of As(III)  Bell, Dorothy
Good analytical results are yielded using the techniques in this brief note.
Bell, Dorothy J. Chem. Educ. 1978, 55, 815.
Bioorganic Chemistry |
Qualitative Analysis
Biochemical roles of some essential metal ions  J. Chem. Educ. Staff
Summarizes the important biochemical roles played by ions of sodium, potassium, calcium, magnesium, zinc, iron, cobalt, and copper.
J. Chem. Educ. Staff J. Chem. Educ. 1977, 54, 761.
Metals |
Organometallics |
Bioinorganic Chemistry
Teaching bio-organometal chemistry. II. The metals  Thayer, John S.
Considers the toxicology and environmental cycles of compounds containing mercury, germanium, tin, lead, antimony, bismuth, cobalt, and other metals.
Thayer, John S. J. Chem. Educ. 1977, 54, 662.
Organometallics |
Bioinorganic Chemistry |
Toxicology
Pheromones and chemical communication in the laboratory  Alger, Donald B.
The topic of chemical communication is of great interest to biology students who may be taking courses in chemistry.
Alger, Donald B. J. Chem. Educ. 1976, 53, 210.
Hormones |
Bioorganic Chemistry |
Molecular Biology |
Molecular Recognition
Microbial oxidation of alkenes. An integrated organic-biology experiment  Kumler, Philip L.; DeJong, Peter J.
The conversion of an appropriate terminal alkene to a 1,2-epoxyalkane by Pseudomonas oleovorans introduces students to the techniques used in carrying out chemical conversions employing microorganisms.
Kumler, Philip L.; DeJong, Peter J. J. Chem. Educ. 1975, 52, 475.
Oxidation / Reduction |
Alkenes |
Bioorganic Chemistry |
Biotechnology |
Natural Products
Molecular oxygen adducts of transition metal complexes  Klevan, Leonard; Peone, Joseph, Jr.; Madan, Stanley K.
Reviews the chemistry of transition metal complexes that are able to bind reversibly to molecular oxygen, particularly complexes of iridium, rhodium, and cobalt.
Klevan, Leonard; Peone, Joseph, Jr.; Madan, Stanley K. J. Chem. Educ. 1973, 50, 670.
Transition Elements |
Coordination Compounds |
Bioinorganic Chemistry |
Metals |
Molecular Properties / Structure