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Synthesis of the Commercial Antidepressant Moclobemide Jesse D. More Describes an experiment for the undergraduate organic chemistry laboratory in which students synthesize the commercial antidepressant drug moclobemide, marketed under the trade name Manerix, in one step using commercially available material. The purity and identity of the product are confirmed by melting point and NMR and IR spectroscopy. More, Jesse D. J. Chem. Educ.2008, 85, 1424.
Drugs / Pharmaceuticals |
IR Spectroscopy |
Medicinal Chemistry |
NMR Spectroscopy |
Synthesis
Chemical Aspects of General Anesthesia: Part II. Current PracticesRobert Brunsvold and Daryl L. Ostercamp With the basic elements of balanced general anesthesia in place by the 1950s, the focus turned to developing safer and more effective agents and to improving procedures. During the last half-century a new generation of intravenous induction anesthetics, inhalational anesthetics, and muscle relaxants has emerged. Brunsvold, Robert; Ostercamp, Daryl L. J. Chem. Educ.2006, 83, 1826.
Bioorganic Chemistry |
Chirality / Optical Activity |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Synthesis
Chemical Aspects of Local and Regional AnesthesiaRobert Brunsvold and Daryl L. Ostercamp The chemistry that underlies the development of local and regional anesthesia is explored. Emphasis is placed upon the importance of acidity constants and lipophilic versus hydrophilic character in interpreting what affect a particular compound has upon biological processes. Brunsvold, Robert; Ostercamp, Daryl L. J. Chem. Educ.2006, 83, 1816.
