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Journal Articles: 22 results
Molecules and Medicine (E. J. Corey, Barbara Czakó, and László Kürti)  Robert E. Buntrock
Looking for a book on common drugs and pharmaceuticals? On diseases and medical conditions? On pharmacology? In addition, do you need some background in chemistry to handle all of this information? If you want all of this, and in addition want it under one cover, then this is the book for you.
Buntrock, Robert E. J. Chem. Educ. 2008, 85, 1495.
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Molecular Properties / Structure |
Proteins / Peptides |
Synthesis |
Toxicology
Kinetic Analysis of Amylase Using Quantitative Benedict's and Iodine Starch Reagents  Beverly Cochran, Deborah Lunday, and Frank Miskevich
This laboratory emphasizes that enzymes mediate the conversion of a substrate into a product and that either the concentration of product or reactant may be used to follow the course of a reaction. It does so by using an inexpensive scanner and open-source image analysis software to quantify amylase activity through the breakdown of starch and the appearance of glucose.
Cochran, Beverly; Lunday, Deborah; Miskevich, Frank. J. Chem. Educ. 2008, 85, 401.
Biosynthesis |
Carbohydrates |
Catalysis |
Enzymes |
Food Science |
Nutrition |
Quantitative Analysis |
UV-Vis Spectroscopy
Structures for the ABO(H) Blood Group: Which Textbook Is Correct?  John M. Risley
Six textbooks and two Internet sites show different structures for the A, B, and O(H) antigens of the ABO(H) blood group, but none of them are correct. This article emphasizes the correct molecular structures because it is important to distinguish between those carbohydrates that make up the antigens and those that are not part of the antigenic structures.
Risley, John M. J. Chem. Educ. 2007, 84, 1546.
Bioorganic Chemistry |
Carbohydrates |
Natural Products |
Molecular Properties / Structure
The A1c Blood Test: An Illustration of Principles from General and Organic Chemistry  Robert C. Kerber
The glycated hemoglobin blood test is a key measure of the effectiveness of glucose control in diabetics. The chemistry of glucose in the bloodstream, which underlies the test and its impact, provides an illustration of the importance of chemical equilibrium and kinetics to a major health problem.
Kerber, Robert C. . J. Chem. Educ. 2007, 84, 1541.
Applications of Chemistry |
Bioinorganic Chemistry |
Carbohydrates |
Mechanisms of Reactions |
Proteins / Peptides |
Bioorganic Chemistry
Receptor Surface Models in the Classroom: Introducing Molecular Modeling to Students in a 3-D World  Werner J. Geldenhuys, Michael Hayes, Cornelis J. Van der Schyf, David D. Allen, and Sarel F. Malan
Proposes a novel method for teaching drug interactions with a receptor, enzyme, or any other macromolecule or protein using plastic molecular models and aluminum foil.
Geldenhuys, Werner J.; Hayes, Michael; Van der Schyf, Cornelis J.; Allen, David D.; Malan, Sarel F. J. Chem. Educ. 2007, 84, 979.
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Laboratory Computing / Interfacing |
Medicinal Chemistry |
Molecular Modeling |
Enzymes
Molecular Model of Zincon  William F. Coleman
The Featured Molecules this month are the tautomeric forms of the colorimetric reagent zincon. The structures could be used as an introduction to the concept of tautomerism, with students being asked to develop a definition of the term based on their observations of the difference(s) in linkage in the two forms.
Coleman, William F. J. Chem. Educ. 2007, 84, 305.
Biological Cells |
Calorimetry / Thermochemistry |
Water / Water Chemistry |
Molecular Mechanics / Dynamics |
Molecular Modeling |
Molecular Properties / Structure
Nature's Way To Make the Lantibiotics  Heather A. Relyea and Wilfred A. van der Donk
This article focuses on one class of antimicrobial compounds, the lantibiotics, and discusses their biosynthetic pathways as well as their molecular mode of action. In the course of the review, the meaning of the terms regio-, chemo-, and stereoselectivity are discussed.
Relyea, Heather A.; van der Donk, Wilfred A. J. Chem. Educ. 2006, 83, 1769.
Applications of Chemistry |
Bioorganic Chemistry |
Biotechnology |
Biosynthesis |
Catalysis |
Drugs / Pharmaceuticals |
Proteins / Peptides
Molecular Model of Creatine Synthesis  William F. Coleman
The Featured Molecules for this month come from the synthesis of creatine and illustrate some of the limitations associated with the computation of molecular structure.
Coleman, William F. J. Chem. Educ. 2006, 83, 1657.
Molecular Modeling |
Molecular Properties / Structure |
Bioorganic Chemistry
Teaching Biologically Relevant Chemistry throughout the Four-Year Chemistry Curriculum  Sarah R. Kirk, Todd P. Silverstein, and Jeffrey J. Willemsen
First-year chemistry students learn introductory chemistry using case studies which deal directly with human health issues and biological processes. Second-year students choose between two equivalent versions of the second-semester course: one that stresses synthetic organic chemistry and another that stresses bioorganic chemistry.
Kirk, Sarah R.; Silverstein, Todd P.; Willemsen, Jeffrey J. J. Chem. Educ. 2006, 83, 1171.
Bioorganic Chemistry |
Bioenergetics
(Strept)Avidin–Biotin: Two Interrelated Experiments for the Introductory Chemistry Laboratory  David E. Hansen, Dengda Tang, Jon A. Sanborn, and Mark D. Marshall
Describes a two-experiment sequence focusing on the noncovalent complex between the egg white protein avidin (or the similar protein streptavidin, which is expressed by the bacterium Streptomyces avidinii) and the essential cofactor biotin. The equilibrium constant for the binding of HABA to avidin is calculated from the data collected.
Hansen, David E.; Tang, Dengda; Sanborn, Jon A.; Marshall, Mark D. J. Chem. Educ. 2006, 83, 777.
Bioorganic Chemistry |
Computational Chemistry |
Equilibrium |
Titration / Volumetric Analysis
DNA Profiling of the D1S80 Locus: A Forensic Analysis for the Undergraduate Biochemistry Laboratory  D. Dewaine Jackson, Chad S. Abbey, and Dylan Nugent
Describes a laboratory exercise in DNA profiling that can be used to demonstrate four fundamental procedures: isolation of genomic DNA from human cells, use of the polymerase chain reaction to amplify DNA, separation of amplified DNAs on agarose and polyacrylamide gels, and quantitative analysis of data (while comparing two different gel separation techniques).
Jackson, D. Dewaine; Abbey, Chad S.; Nugent, Dylan. J. Chem. Educ. 2006, 83, 774.
Biological Cells |
Biotechnology |
Electrophoresis |
Forensic Chemistry |
Molecular Biology |
Quantitative Analysis |
Nucleic Acids / DNA / RNA
Gifts from Mother Earth—The Good, the Bad, and the Ugly  Sabine Heinhorst and Gordon C. Cannon
Recent articles from the journal Nature that deal with good, bad, and ugly gifts from Mother Earth are described.
Heinhorst, Sabine; Cannon, Gordon C. J. Chem. Educ. 2006, 83, 196.
Biosynthesis |
Biotechnology |
Natural Products |
Nutrition |
Plant Chemistry |
Polymerization |
Proteins / Peptides
Synthesis of a Racemic Ester and Its Lipase–Catalyzed Kinetic Resolution  Delia Stetca, Isabel W. C. E. Arends, and Ulf Hanefeld
Reaction sequence to familiarize first-year students with the use of enzymes in organic chemistry.
Stetca, Delia; Arends, Isabel W. C. E.; Hanefeld, Ulf. J. Chem. Educ. 2002, 79, 1351.
Bioinorganic Chemistry |
Enzymes |
Catalysis |
Synthesis |
Enantiomers |
Bioorganic Chemistry
Bioorganic First: A New Model for the College Chemistry Curriculum  I. David Reingold
Case for making bioorganic chemistry the introductory chemistry course for all college freshmen.
Reingold, I. David. J. Chem. Educ. 2001, 78, 869.
Bioorganic Chemistry
Combinatorial Synthesis and Discovery of an Antibiotic Compound. An Experiment Suitable for High School and Undergraduate Laboratories  Scott E. Wolkenberg and Andrew I. Su
An experiment designed to introduce students to combinatorial chemistry as applied to drug discovery.
Wolkenberg, Scott E.; Su, Andrew I. J. Chem. Educ. 2001, 78, 784.
Aqueous Solution Chemistry |
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Synthesis |
Combinatorial Chemistry |
Applications of Chemistry
A Chemical-Medical Mystery: Gold Jewelry and Black Marks on Skin  Barbara B. Kebbekus
Gold jewelry at times makes a black mark or smudge on skin. This may be caused by abrasive powders on the skin (e.g. zinc oxide) but the phenomenon may also be caused by other skin conditions, possibly the presence of chloride ion, acidity, or sulfur-containing amino acids.
Kebbekus, Barbara B. J. Chem. Educ. 2000, 77, 1298.
Bioorganic Chemistry |
Geochemistry |
Hormones |
Metals |
Solids |
Applications of Chemistry
Two Faces of Alkaloids  Jirí Dostál
The article discusses and compares the salts and free bases of six well-known alkaloids: nicotine, morphine, cocaine, sanguinarine, allocryptopine, and magnoflorine. Relevance for the biological and medical uses of these compounds is emphasized.
Dostál, Jirí. J. Chem. Educ. 2000, 77, 993.
Acids / Bases |
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Natural Products |
Aromatic Compounds |
Medicinal Chemistry
The Other Double Helix--The Fascinating Chemistry of Starch  Robert D. Hancock and Bryon J. Tarbet
The chemistry of starch, particularly the structure of starch and starch granules.
Hancock, Robert D.; Tarbet, Bryon J. J. Chem. Educ. 2000, 77, 988.
Bioorganic Chemistry |
Carbohydrates |
Food Science |
Stereochemistry |
Applications of Chemistry |
Molecular Properties / Structure
Iron as Nutrient and Poison  N. M. Senozan and M. P. Christiano
Iron containing compounds of the body and the ingestion and elimination of iron, the function and transport of this metal among different sites and substances of the body, and biochemical defects and nutritional habits that lead to excessive accumulation of iron and some unexpected consequences of this accumulation are described.
Senozan, N. M.; Christiano, M. P. J. Chem. Educ. 1997, 74, 1060.
Bioinorganic Chemistry |
Bioorganic Chemistry |
Food Science |
Metals |
Vitamins |
Toxicology |
Nutrition |
Applications of Chemistry |
Descriptive Chemistry
Elements of General, Organic, and Biological Chemistry, Ninth Edition  reviewed by John Ganchoff
The audience for this text includes students in the health sciences (other than physicians) and nonscience students with an interest in the molecular nature of matter. The text can be used for a one-term course and does not have any chemistry prerequisites.
Ganchoff, John. J. Chem. Educ. 1996, 73, A135.
Bioorganic Chemistry |
Nonmajor Courses
An Attack on the AIDS Virus: Inhibition of the HIV-1 Protease. New Drug Development Based on the Structure and Activity of the Protease and its Role in the Replication and Maturation of the Virus  Volker, Eugene J.
Article shows how research into the biochemistry of HIV may lead to a method for controlling its growth and maturation. This research illustrates some basic enzyme chemistry and holds student appeal due to the tie into current affairs.
Volker, Eugene J. J. Chem. Educ. 1993, 70, 3.
Bioorganic Chemistry |
Proteins / Peptides |
Medicinal Chemistry |
Molecular Biology
The chemical composition of the cell  Holum, John R.
A broad outline of the chemical substances that occur in most cells.
Holum, John R. J. Chem. Educ. 1984, 61, 877.
Biological Cells |
Lipids |
Carbohydrates |
Proteins / Peptides