| Journal Articles: 35 results |
|
|
Identification of an Unknown Compound by Combined Use of IR, 1H NMR, 13C NMR, and Mass Spectrometry: A Real-Life Experience in Structure Determination Louis J. Liotta and Magdalena James-Pederson
In this introductory organic chemistry experiment, students are expected to operate NMR, IR, and GCMS instrumentation to obtain spectra which are interpreted to elucidate the chemical structure of the assigned compounds without the benefit of a list of possible unknowns.
Liotta, Louis J.; James-Pederson, Magdalena. J. Chem. Educ. 2008, 85, 832.
Gas Chromatography |
Instrumental Methods |
IR Spectroscopy |
Mass Spectrometry |
Molecular Properties / Structure |
NMR Spectroscopy |
Qualitative Analysis |
Spectroscopy
|
Illustrating the Concepts of Isotopes and Mass Spectrometry in Introductory Courses: A MALDI-TOF Mass Spectrometry Laboratory Experiment Nancy Carter Dopke and Timothy Neal Lovett
This article describes a matrix-assisted laser desorption/ionization (MALDI) mass spectrometry experiment in which students prepare peptide samples for mass analysis and then collect and analyze mass spectral data. The lab provides hands-on experience with research instrumentation and reinforces the concepts of isotopes, molecular masses, and molecular formulas.
Dopke, Nancy Carter; Lovett, Timothy Neal. J. Chem. Educ. 2007, 84, 1968.
Isotopes |
Mass Spectrometry |
Proteins / Peptides
|
Teaching Science in Art Erich S. Uffelman
Describes two linked, interdisciplinary courses examining conservation science and the history of 17th-century Dutch painting. Strengths and limitations of the approaches taken are discussed and key resources cited.
Uffelman, Erich S. J. Chem. Educ. 2007, 84, 1617.
Applications of Chemistry |
Dyes / Pigments |
Instrumental Methods |
Lasers |
Mass Spectrometry |
Spectroscopy
|
Understanding Isotopic Distributions in Mass Spectrometry Juris Meija
Offers a simple graphical tool for obtaining complex isotopic distributions.
Meija, Juris. J. Chem. Educ. 2006, 83, 1761.
Mass Spectrometry |
Isotopes |
Chemometrics
|
Analysis of the Thickening Agents in Automotive Greases by GC–MS David Mayotte, Craig J. Donahue, and Cheryl A. Snyder
Describes a laboratory procedure for the identification of the thickening agents in lubricating greases by GCMS.
Mayotte, David; Donahue, Craig J.; Snyder, Cheryl A. J. Chem. Educ. 2006, 83, 902.
Applications of Chemistry |
Consumer Chemistry |
Gas Chromatography |
Industrial Chemistry |
Mass Spectrometry |
Separation Science |
Fatty Acids
|
4-Dimethylaminopyridine or Acid-Catalyzed Syntheses of Esters: A Comparison Annemieke W. C. van den Berg and Ulf Hanefeld
Students compare acid-catalyzed ester synthesis and the 4-dimethylaminopyridine-catalyzed reaction. Based on the outcome of the experiments, students discuss the different reaction mechanisms and reason why different products are formed.
van den Berg, Annemieke W. C.; Hanefeld, Ulf. J. Chem. Educ. 2006, 83, 292.
Acids / Bases |
Catalysis |
Chromatography |
Esters |
IR Spectroscopy |
NMR Spectroscopy |
Mass Spectrometry |
Synthesis |
Mechanisms of Reactions
|
Presumptive and Confirmatory Drug Tests Craig Anderson
Tests for illegal drugs were performed on unknowns obtained from over-the-counter cold medicines. Substances that tested positive for the qualitative Marquis color test were found to be false positives for illegal substances, while scopolamine hydrochloride shows a false positive for cocaine hydrochloride with the cobalt thiocyanate reagent.
Anderson, Craig. J. Chem. Educ. 2005, 82, 1809.
Drugs / Pharmaceuticals |
Qualitative Analysis |
Acids / Bases |
Gas Chromatography |
IR Spectroscopy |
Mass Spectrometry
|
Thermal Degradation and Identification of Heat-Sensitive Polymers. Applications of Pyrolysis and Distillation and Instrumental Methods of Analysis Stuart C. Clough and Emma W. Goldman
An experiment for undergraduate teaching laboratories is described that involves the identification of samples of polystyrene and poly(methyl methacrylate). This involves the thermal degradation of the polymers (a destructive distillation) into their respective monomers. The monomers are then identified using infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and gas chromatographymass spectrometry.
Clough, Stuart C.; Goldman, Emma W. J. Chem. Educ. 2005, 82, 1378.
Nonmajor Courses |
IR Spectroscopy |
Mass Spectrometry |
NMR Spectroscopy |
Polymerization
|
Applying Chemical Potential and Partial Pressure Concepts To Understand the Spontaneous Mixing of Helium and Air in a Helium-Inflated Balloon Jee-Yon Lee, Hee-Soo Yoo, Jong Sook Park, Kwang-Jin Hwang, and Jin Seog Kim
In developing this laboratory, our initial motivation for the analysis of gases in a balloon was to answer simple and basic questions, such as, Why does a helium-charged balloon left in the air always drop in a few days? Is leakage of helium the only cause of the drop? What is the composition of the gas in the balloon when it falls after deflation? Students were intrigued by these questions, too, as they analyzed the variation over time in the composition in a balloon inflated with helium. Using the concepts of partial pressure and chemical potential, the laboratory experiment described effectively investigates the diffusion process and the behavior of gas molecules for teaching these concepts in general and physical chemistry.
Lee, Jee-Yon; Yoo, Hee-Soo; Park, Jong Sook; Hwang, Kwang-Jin; Kim, Jin Seog. J. Chem. Educ. 2005, 82, 288.
Transport Properties |
Gases |
Mass Spectrometry |
Quantitative Analysis
|
Introduction of Mass Spectrometry in a First-Semester General Chemistry Laboratory Course: Quantification of MTBE or DMSO in Water Mike Solow
An experiment has been developed to introduce first-semester general chemistry students to mass spectrometry. Students analyze water samples contaminated with a known compound, either DMSO or MTBE. Students are asked to determine the concentration of the compound in the water. In performing this experiment, students should learn (i) how the mass of an atom or molecule is determined, (ii) the effect of the presence of different isotopes on molecular mass, (iii) the role of an internal standard, and (iv) how mass spectrometry is used in answering various scientific questions.
Solow, Mike. J. Chem. Educ. 2004, 81, 1172.
Instrumental Methods |
Mass Spectrometry |
Quantitative Analysis |
Water / Water Chemistry |
Gas Chromatography
|
Mass Spectrometry for the Masses Jared D. Persinger, Geoffrey C. Hoops, and Michael J. Samide
In this article, we describe an experiment for an introductory chemistry course that incorporates the use of mass spectrometry for sample analysis. Several different air samples are collected that represent various chemical processes, and the composition of the air sample is predicted on the basis of known chemical principles. A gas chromatograph-mass spectrometer is used to analyze these samples, and the relative quantities of nitrogen, oxygen, carbon dioxide, water, and argon are calculated. On the basis of the data, the hypothesized sample composition is validated.
Persinger, Jared D.; Hoops, Geoffrey C.; Samide, Michael J. J. Chem. Educ. 2004, 81, 1169.
Mass Spectrometry |
Atmospheric Chemistry |
Green Chemistry |
Nonmajor Courses |
Oxidation / Reduction |
Photosynthesis |
Gases
|
Mass Spectra JCE Editorial Staff
Activity in which students solve puzzles analogous to finding the amino acid sequence of a peptide using mass spectrometry.
JCE Editorial Staff. J. Chem. Educ. 2003, 80, 176A.
Amino Acids |
Mass Spectrometry |
Proteins / Peptides
|
News from Online: Teaching with Chemical Instrumentation on the Web Thomas G. Chasteen
Variety of web-based animations on analytical instrumentation; WWW addresses for software, plug-ins, sites for images and animations, references for designing sites, and sites regarding specific analytical techniques.
Chasteen, Thomas G. J. Chem. Educ. 2001, 78, 1144.
Instrumental Methods |
Molecular Modeling |
Spectroscopy |
Chromatography |
Mass Spectrometry |
Gas Chromatography |
Fluorescence Spectroscopy
|
Metal Complexes of Trifluoropentanedione. An Experiment for the General Chemistry Laboratory Robert C. Sadoski, David Shipp, and Bill Durham
Investigation of the transition-metal complexes produced by the reactions of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), and Cu(II) with 1,1,1-trifluoro-2,4-pentanedione; mass spectroscopy is used to determine the stoichiometry of the reaction products.
Sadoski, Robert C.; Shipp, David; Durham, Bill. J. Chem. Educ. 2001, 78, 665.
Coordination Compounds |
Synthesis |
Mass Spectrometry |
Transition Elements |
Stoichiometry
|
A Strategy for Incorporating Hands-On GC-MS into the General Chemistry Lecture and Laboratory Courses Perry C. Reeves and Kim L. Pamplin
Students use the GC-MS to obtain spectra of the various halobenzenes. This vividly illustrates the differences in isotopic distributions of the halogens and the complications these differences present in calculating molar masses of compounds. The isotopic distribution of iron is then obtained from the mass spectrum of Fe(CO)5, and the students calculate the atomic mass of iron from this data.
Reeves, Perry C.; Pamplin, Kim L. J. Chem. Educ. 2001, 78, 368.
Chromatography |
Isotopes |
Mass Spectrometry |
Gas Chromatography |
Aromatic Compounds
|
No, the Molecular Mass of Bromobenzene Is Not 157 amu: An Exercise in Mass Spectrometry and Isotopes for Early General Chemistry Steven M. Schildcrout
Even with no background in bonding and structure, students can successfully interpret the output of a modern research instrument. They learn to identify an isotope pattern, assign chemical formulas to ions giving mass spectral peaks, calculate an average atomic weight (for bromine) from measured isotopic abundances, and write balanced equations for ion fragmentation reactions.
Schildcrout, Steven M. J. Chem. Educ. 2000, 77, 1433.
Isotopes |
Mass Spectrometry |
Atomic Properties / Structure |
Molecular Properties / Structure
|
Determination of Aspartame and Caffeine in Carbonated Beverages Utilizing Electrospray Ionization-Mass Spectrometry H. Robert Bergen III, Linda M. Benson, and Stephen Naylor
High school students utilize ESI-MS in an analysis of aspartame and caffeine. The lab is procedurally simple and the results clearly demonstrate the potential and limitations of ESI-coupled mass spectrometry.
Bergen, H. Robert, III; Benson, Linda M.; Naylor, Stephen. J. Chem. Educ. 2000, 77, 1325.
Instrumental Methods |
Mass Spectrometry |
Quantitative Analysis
|
Pesticides in Drinking Water: Project-Based Learning within the Introductory Chemistry Curriculum Patricia B. O'Hara, Jon A. Sanborn, and Meredith Howard
A new introductory chemistry module is described, which has as its central theme the measurement of trace levels of these xenoestrogens in the form of pesticides in the Town of Amherst's public drinking water. After a basic introduction to sample handling and measurement of pH, temperature, and conductivity, the students travel in small groups to several sites to collect water and perform preliminary characterization of their samples.
OHara, Patricia B.; Sanborn, Jon A.; Howard, Meredith. J. Chem. Educ. 1999, 76, 1673.
Mass Spectrometry |
Water / Water Chemistry |
Toxicology |
Applications of Chemistry
|
Correction to "How Mathematics Figures in Chemistry: Some Examples" (J. Chem. Educ. 1999, 76, 258-267) John Andraos
With respect to the widths of parabolas discussed in Problem 3, shallow wells should be characterized as having the a parameter between 0 and 1 (0 < a < 1). The words "deep" and "shallow" appearing in the paragraph following eq 17 are incorrectly transposed.
Andraos, John. J. Chem. Educ. 1999, 76, 897.
Mass Spectrometry |
Photochemistry
|
A General Chemistry Experiment Incorporating Synthesis and Structural Determination Hal Van Ryswyk
An experiment for the general chemistry laboratory is described wherein gas chromatography-mass spectroscopy (GC-MS) and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) are used to characterize the products of a series of microscale reactions on vanillin.
Van Ryswyk, Hal. J. Chem. Educ. 1997, 74, 842.
Instrumental Methods |
Microscale Lab |
Synthesis |
Molecular Properties / Structure |
Gas Chromatography |
Mass Spectrometry |
Fourier Transform Techniques |
Spectroscopy
|
News from On-Line Carolyn Sweeney Judd
Helpful chemistry WWW sites.
Judd, Carolyn Sweeney. J. Chem. Educ. 1997, 74, 620.
IR Spectroscopy |
Mass Spectrometry
|
Electrospray Ionization Mass Spectroscopy: Part I. Instrumentation and Spectral Interpretation Steven A. Hofstadler, Ray Bakhtiar, and Richard D. Smith
ESI-MS is now one of the most widely utilized and fastest growing mass spectrometric techniques for the analysis of biomolecular species. This article is intended to introduce the theory, principles, and instrumentation of ESI-MS to teachers, researchers, and future researchers with a rudimentary knowledge of ion formation, separation, and detection processes.
Hofstadler, Steven A.; Bakhtiar, Ray; and Smith, Richard D. J. Chem. Educ. 1996, 73, A82.
Mass Spectrometry |
Instrumental Methods |
Bioanalytical Chemistry
|
An LC/Particle Beam/MS Experiment for Undergraduates Norman Sproch, Kelly J. Begin, and Robert J. Morris
Sproch, Norman; Begin, Kelly J.; Morris, Robert J. J. Chem. Educ. 1996, 73, A33.
Instrumental Methods |
Mass Spectrometry |
HPLC
|
Use of Gas Chromatography-Mass Spectrometry (GC-MS) in Nonscience Major Course Laboratory Experiments Keith S. Kostecka, Zafra M. Lerman, and Sanford A. Angelos
Our efforts have centered on introducing prospective science communicators (film, video, radio, television, and journalism majors) to science relative to their majors and personal interests. Quality lecture-discussion topics, "mystery"-based laboratory activities have assisted in introducing and/or explaining specific areas of chemistry that attempt to reduce fear of subject matter.
Keith S. Kostecka, Zafra M. Lerman, and Sanford A. Angelos. J. Chem. Educ. 1996, 73, 565.
Nonmajor Courses |
Gas Chromatography |
Mass Spectrometry |
Chromatography |
Forensic Chemistry |
Separation Science
|
In This Issue
The instruments that chemists use in their research have changed dramatically in the past decades. The explosion in new techniques and their instrumental counterparts has been made possible by two significant advances.
J. Chem. Educ. 1996, 73, 288.
NMR Spectroscopy |
Mass Spectrometry |
Instrumental Methods
|
Mass Spectrometry Analogy on the Overhead Projector Nancy C. Grim and Jerry L. Sarquis
Overhead projector demonstration of the principle behind mass spectroscopy.
Grim, Nancy C.; Sarquis, Jerry L. J. Chem. Educ. 1995, 72, 930.
Mass Spectrometry
|
Crayons, Boxes, and Books: A Model for Mass Spectrometry Crute, Thomas D.; Myers, Stephanie A.
Analogy for helping students to understand the basic principle and operation of mass spectrometry.
Crute, Thomas D.; Myers, Stephanie A. J. Chem. Educ. 1995, 72, 232.
Mass Spectrometry
|
Models and molecules: A laboratory-based course in spectroscopy for the nonscience major Werner, T. C.; Hull, L. A.
Recent general education curriculum requirements at the authors' institution led to the development of several laboratory-based courses for nonscience majors. One such course is presented in this paper.
Werner, T. C.; Hull, L. A. J. Chem. Educ. 1993, 70, 936.
Nonmajor Courses |
Spectroscopy |
Mass Spectrometry |
IR Spectroscopy |
NMR Spectroscopy
|
Integrating research instrumentation with the general chemistry curriculum. Part I: Mass spectrometry Eichstadt, Karen E.
A three-part exercise entitled "A Glimpse of Mass Spectrometry" was designed for students enrolled in the third quarter of a one-year, nonmajor course that surveyed organic and biological chemistry.
Eichstadt, Karen E. J. Chem. Educ. 1992, 69, 48.
Mass Spectrometry |
Laboratory Equipment / Apparatus |
Nonmajor Courses
|
Mass spectrometer interface with an Apple II computer Stahl, John W.
The author upgraded a low-cost mass spectrometer into a very functional instrument using a commercial computer interface, some hardware modification, and custom-written software.
Stahl, John W. J. Chem. Educ. 1990, 67, A72.
Laboratory Computing / Interfacing |
Mass Spectrometry
|
An integrated first-year laboratory experiment involving synthesis, spectroscopy, and chromatography of metal acetylacetonates Glidewell, Christopher; McKenchnic, James S.
This article presents a comprehensive experiment, involving synthesis, thin-layer chromatography, interpretation of two types of NMR and mass spectra.
Glidewell, Christopher; McKenchnic, James S. J. Chem. Educ. 1988, 65, 1015.
NMR Spectroscopy |
Mass Spectrometry |
Synthesis |
Separation Science |
Thin Layer Chromatography
|
Radioactive dating: A method for geochronology Rowe, M. W.
The discovery of radioactivity, radioactive dating, and various dating methods.
Rowe, M. W. J. Chem. Educ. 1985, 62, 580.
Geochemistry |
Nuclear / Radiochemistry |
Isotopes |
Mass Spectrometry
|
Mass spectral analysis of halogen compounds Holdsworth, David K.
37. Bits and pieces, 14. A pocket calculator can be programmed to decide and display the halogen combination in a molecular-ion cluster by examination of the (M+2)/M or (X+2)/X percentage values.
Holdsworth, David K. J. Chem. Educ. 1983, 60, 103.
Chemometrics |
Mass Spectrometry
|
But if atoms are so tiny... Kolb, Doris
Reviews the atomic theory, the laws of chemical combination, atomic weight scales, Avogadro's hypothesis, the development of the mass spectrograph, the meaning of atomic weight, and the difference between mass and weight in answering the question "If atoms are so small, how can we know how much they weigh?" [Debut]
Kolb, Doris J. Chem. Educ. 1977, 54, 543.
Atomic Properties / Structure |
Kinetic-Molecular Theory |
Mass Spectrometry
|
Questions [and] Answers Campbell, J. A.
Five questions requiring an application of basic chemical principles.
Campbell, J. A. J. Chem. Educ. 1972, 49, 328.
Enrichment / Review Materials |
Applications of Chemistry |
Nuclear / Radiochemistry |
Thermodynamics |
Mass Spectrometry |
Isotopes
|
|
