| Journal Articles: 10 results |
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Molecules and Medicine (E. J. Corey, Barbara Czakó, and László Kürti) Robert E. Buntrock
Looking for a book on common drugs and pharmaceuticals? On diseases and medical conditions? On pharmacology? In addition, do you need some background in chemistry to handle all of this information? If you want all of this, and in addition want it under one cover, then this is the book for you.
Buntrock, Robert E. J. Chem. Educ. 2008, 85, 1495.
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Molecular Properties / Structure |
Proteins / Peptides |
Synthesis |
Toxicology
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Mentoring an Undergraduate Research Student in the Structural and Nonstructural Properties of Drugs Julie B. Ealy and Veronica Kvarta
This article describes research, conducted with an undergraduate, to investigate the structural and nonstructural characteristics of drugs and their significance in drug research.
Ealy, Julie B.; Kvarta, Veronica. J. Chem. Educ. 2006, 83, 1779.
Applications of Chemistry |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Molecular Modeling |
Molecular Properties / Structure |
Undergraduate Research |
Student-Centered Learning
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Nature's Way To Make the Lantibiotics Heather A. Relyea and Wilfred A. van der Donk
This article focuses on one class of antimicrobial compounds, the lantibiotics, and discusses their biosynthetic pathways as well as their molecular mode of action. In the course of the review, the meaning of the terms regio-, chemo-, and stereoselectivity are discussed.
Relyea, Heather A.; van der Donk, Wilfred A. J. Chem. Educ. 2006, 83, 1769.
Applications of Chemistry |
Bioorganic Chemistry |
Biotechnology |
Biosynthesis |
Catalysis |
Drugs / Pharmaceuticals |
Proteins / Peptides
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Synthesis and Analysis of a Versatile Imine for the Undergraduate Organic Chemistry Laboratory Jacqueline Bennett, Kristen Meldi, and Christopher Kimmell II
In this experiment students prepare and analyze N-p-methoxyphenyl (N-PMP) alpha-imino ethyl glyoxalate, an imine that has been used in the synthesis of biologically active molecules. The stability and versatility of this imine allow it to be used in subsequent reactions, offering a variety of possible multistep synthetic strategies.
Bennett, Jacqueline; Meldi, Kristen; Kimmell, Christopher, II. J. Chem. Educ. 2006, 83, 1221.
Aldehydes / Ketones |
Gas Chromatography |
Green Chemistry |
Mass Spectrometry |
NMR Spectroscopy |
Synthesis
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Acetal Protecting Groups in the Organic Laboratory: Synthesis of Methyl 4,6-O-Benzylidene-α-D-Glucopyranoside Alexei V. Demchenko, Papapida Pornsuriyasak, and Cristina De Meo
The synthesis of methyl 4,6-O-benzylidene-a-D-glucopyranoside provides an opportunity to synthesize a cyclic acetal; stereoselectively introduce a chirality center; and learn extraction, evaporation, precipitation, optical rotation, melting point measurement, thin-layer chromatography, IR-spectroscopy, mass spectrometry, and various NMR techniques.
Demchenko, Alexei V.; Pornsuriyasak, Papapida; De Meo, Cristina. J. Chem. Educ. 2006, 83, 782.
Carbohydrates |
IR Spectroscopy |
Medicinal Chemistry |
NMR Spectroscopy |
Thin Layer Chromatography |
Synthesis
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Microwave-Assisted Heterocyclic Chemistry for Undergraduate Organic Laboratory Robert Musiol, Bozena Tyman-Szram, and Jaroslaw Polanski
Microwave-assisted techniques are used to design new environmentally benign syntheses of heterocycles for the undergraduate organic laboratory.
Musiol, Robert; Tyman-Szram, Bozena; Polanski, Jaroslaw. J. Chem. Educ. 2006, 83, 632.
Green Chemistry |
Heterocycles |
Reactions |
Synthesis
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A Supramolecular Approach to Medicinal Chemistry: Medicine Beyond the Molecule David K. Smith
This article emphasizes a conceptual view of medicinal chemistry, which has important implications for the future, as the supramolecular approach to medicinal-chemistry products outlined here is rapidly allowing nanotechnology to converge with medicine. In particular, this article discusses recent developments including the rational design of drugs such as Relenza and Tamiflu, the mode of action of vancomycin, and the mechanism by which bacteria develop resistance, drug delivery using cyclodextrins, and the importance of supramolecular chemistry in understanding protein aggregation diseases such as Alzheimer's and CreutzfieldJacob.
Smith, David K. J. Chem. Educ. 2005, 82, 393.
Drugs / Pharmaceuticals |
Noncovalent Interactions |
Medicinal Chemistry |
Nanotechnology |
Proteins / Peptides
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Milk as a Drug Analysis Medium: HPLC Determination of Isoniazid Enzo Sottofattori, Riccardo Raggio, and Olga Bruno
Using milk as a safer biological fluid for drug analysis; detecting isoniazid in cow's milk through HPLC.
Sottofattori, Enzo; Raggio, Riccardo; Bruno, Olga. J. Chem. Educ. 2003, 80, 547.
Chromatography |
Drugs / Pharmaceuticals |
Food Science |
Proteins / Peptides |
HPLC |
Quantitative Analysis |
Applications of Chemistry
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A multidimensional experiment. Synthesis of sulfa drug and its use as a chemotherapeutic agent Krantz, A.; Jesaitis, R. G.
Students synthesize sulfanilamide or sulfathiazole and independently investigate their effect on bacteria cultures.
Krantz, A.; Jesaitis, R. G. J. Chem. Educ. 1973, 50, 76.
Synthesis |
Drugs / Pharmaceuticals
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Alicyclic chemistry: The playground for organic chemists Ferguson, Lloyd N.
This article reviews a number of general topics that have been of special interest in alicyclic chemistry, including conformational analysis, the nonclassical versus classical norbornyl cation, Woodward-Hoffmann electrolytic rules, the aromaticity of nonbenzoid rings, strained ring systems, bridgehead activity, and photochemical syntheses and rearrangements.
Ferguson, Lloyd N. J. Chem. Educ. 1969, 46, 404.
Conformational Analysis |
Synthesis |
Photochemistry
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