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For the textbook, chapter, and section you specified we found
2 Molecular Structures
71 Journal Articles
2 Other Resources
Molecular Structures: 2 results
D-amphetamine C9H13N

3D Structure

Link to PubChem

Amines / Ammonium Compounds |
Drugs / Pharmaceuticals |
Aromatic Compounds |
Acids / Bases

diazepam C16H13ClN2O

3D Structure

Link to PubChem

Heterocycles |
Drugs / Pharmaceuticals |
Amides |
Aromatic Compounds |
Acids / Bases

Journal Articles: First 3 results.
Pedagogies:
A Web-Based Interactive Module to Teach Acid–Base Principles of Drug Action  Maria A. Hernandez and Jolanta Czerwinska
Describes interactive compressed video teleconferencing as the distance learning format for an entry-level doctor of pharmacy program.
Hernandez, Maria A.; Czerwinska, Jolanta. J. Chem. Educ. 2008, 85, 1704.
Acids / Bases |
Drugs / Pharmaceuticals
Real-World Topics: Medicinal Chemistry  Arrietta Clauss
Instructors often look for real-world topics that interest students when designing labs and preparing lectures. The chemistry associated with drugs is a fertile area, and the archives of the Journal can be a resource for interesting drug-related activities to enhance student learning.
Clauss, Arrietta. J. Chem. Educ. 2008, 85, 1657.
Enrichment / Review Materials |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Applications of Chemistry
Investigating the Stability of Benzoyl Peroxide in Over-the-Counter Acne Medications  Marina Canepa Kittredge, Kevin W. Kittredge, Melissa S. Sokol, Arlyne M. Sarquis, and Laura M. Sennet
Students use peroxide strips to investigate the stability of the benzoyl peroxide found in an over-the-counter acne medication when added to various solutions of water, ethanol, polyethylene glycol, and isopropyl myristate.
Canepa Kittredge, Marina; Kittredge, Kevin W.; Sokol, Melissa S.; Sarquis, Arlyne M.; Sennet, Laura M. J. Chem. Educ. 2008, 85, 1655.
Consumer Chemistry |
Drugs / Pharmaceuticals |
Nonmajor Courses |
Solutions / Solvents
View all 71 articles
Other Resources: 2 results
Molecular Models of Real and Mock Illicit Drugs from a Forensic Chemistry Activity  William F. Coleman
The Featured Molecules for this month come from the paper by Shawn Hasan, Deborah Bromfield-Lee, Maria T. Oliver-Hoyo, and Jose A. Cintron-Maldonado (1). The authors describe a forensic chemistry exercise in which model compounds are used to simulate the behavior of various drugs in a series of chemical tests. Structures of a number of the chemicals used in the experiment, and several of the drugs they are serving as proxy for, have been added to the molecule collection. Other substances used in the experiment are already part of the collection, including caffeine and aspirin. One structure that may be both intriguing and confusing to students is that of chlorpromazine (Thorazine, Figure 1). A majority of students might well expect the ring portion of the molecule to show a planar structure. This is not what is found from calculations at the HF/6311++G(d,p) level in both the gas phase and in water. Instead, the three rings are in a V-like formation with a deformation of approximately 50 degrees from planarity. Tracking down the source of this non-planarity would be a useful computational exercise. Does it arise from the presence of the alkyl chain (steric effect), from the chloro group (electronic effect), or from electronic effects involving the elements of the heterocyclic ring? As a starting point to addressing these questions, students could be introduced to the use of model compounds in computation. One such compound would be the parent ring system phenothiazine (Figure 2). That molecule contains neither a chloro substituent nor an extended alkyl group. Is it also found to be non-planar? Is the deformation angle the same, larger, or smaller than in chlorpromazine? Does the addition of chloro group to phenothiazene change the angle significantly? What about the addition of an alkyl group? If the model compound is forced to be planar are all of the vibrational frequencies real (positive)? If not, what type of deformation is suggested by the imaginary (negative) vibration?
Drugs / Pharmaceuticals |
Forensic Chemistry
Molecular Models of Plant Hormones  William F. Coleman
The paper "Synthesis of Plant Auxin Derivatives and Their Effects on Ceratopteris richardii" by Corey E. Stilts and Roxanne Fisher describing an experiment begun in the organic labs and completed in a biochemistry cell biology lab provides the featured molecules for this month. The molecules in Figure 1 of that paper have been added to the collection. There is nothing particularly surprising about their structures, but students might be interested in seeing whether they can determine any structure/regulating effect relationships as the number of synthesized auxin derivatives grows. Additionally, students with little or no biochemistry background might wish to explore other systems that act as growth regulating hormones in plants, as an introduction to the variety of molecular structures that can display such bioactivity. Such molecules range from the very simple, ethene, to the adenine-derived cytokinins (an example of which, zealtin, is shown here) and the brassinosteroids. Brassinolide, a commonly occurring brassin, is also shown. These latter two structures have also been added to the molecule collection. All of the structures have been optimized at the HF/6-31G(d) level.
Synthesis |
Biological Cells |
Hormones |
Bioorganic Chemistry