TIGER

Journal Articles: 68 results
A Web-Based Interactive Module to Teach Acid–Base Principles of Drug Action  Maria A. Hernandez and Jolanta Czerwinska
Describes interactive compressed video teleconferencing as the distance learning format for an entry-level doctor of pharmacy program.
Hernandez, Maria A.; Czerwinska, Jolanta. J. Chem. Educ. 2008, 85, 1704.
Acids / Bases |
Drugs / Pharmaceuticals
Real-World Topics: Medicinal Chemistry  Arrietta Clauss
Instructors often look for real-world topics that interest students when designing labs and preparing lectures. The chemistry associated with drugs is a fertile area, and the archives of the Journal can be a resource for interesting drug-related activities to enhance student learning.
Clauss, Arrietta. J. Chem. Educ. 2008, 85, 1657.
Enrichment / Review Materials |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Applications of Chemistry
Investigating the Stability of Benzoyl Peroxide in Over-the-Counter Acne Medications  Marina Canepa Kittredge, Kevin W. Kittredge, Melissa S. Sokol, Arlyne M. Sarquis, and Laura M. Sennet
Students use peroxide strips to investigate the stability of the benzoyl peroxide found in an over-the-counter acne medication when added to various solutions of water, ethanol, polyethylene glycol, and isopropyl myristate.
Canepa Kittredge, Marina; Kittredge, Kevin W.; Sokol, Melissa S.; Sarquis, Arlyne M.; Sennet, Laura M. J. Chem. Educ. 2008, 85, 1655.
Consumer Chemistry |
Drugs / Pharmaceuticals |
Nonmajor Courses |
Solutions / Solvents
Molecules and Medicine (E. J. Corey, Barbara Czakó, and László Kürti)  Robert E. Buntrock
Looking for a book on common drugs and pharmaceuticals? On diseases and medical conditions? On pharmacology? In addition, do you need some background in chemistry to handle all of this information? If you want all of this, and in addition want it under one cover, then this is the book for you.
Buntrock, Robert E. J. Chem. Educ. 2008, 85, 1495.
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Molecular Properties / Structure |
Proteins / Peptides |
Synthesis |
Toxicology
Molecular Models of Real and Mock Illicit Drugs from a Forensic Chemistry Activity  William F. Coleman
The Featured Molecules for this month have been drawn from a forensic chemistry exercise in which model compounds are used to simulate the behavior of various drugs in a series of chemical tests. The compounds considered include chlorpromazine (Thorazine) and phenothiazine, both involved in the manufacture of antipsychotic drugs.
Coleman, William F. J. Chem. Educ. 2008, 85, 880.
Drugs / Pharmaceuticals |
Forensic Chemistry |
Molecular Properties / Structure |
Molecular Modeling
Using Laboratory Chemicals To Imitate Illicit Drugs in a Forensic Chemistry Activity  Shawn Hasan, Deborah Bromfield-Lee, Maria T. Oliver-Hoyo, and Jose A. Cintron-Maldonado
This forensic chemistry activity utilizes forensic procedures (chemical spot tests and thin-layer chromatography) on laboratory chemicals that mimic actual street drugs to produce screening results similar to those for controlled substances.
Hasan, Shawn; Bromfield-Lee, Deborah; Oliver-Hoyo, Maria T.; Cintron-Maldonado, Jose A. J. Chem. Educ. 2008, 85, 813.
Applications of Chemistry |
Drugs / Pharmaceuticals |
Forensic Chemistry |
Thin Layer Chromatography
A Simple Experiment in the Separation of a Solid-Phase Mixture and Infrared Spectroscopy for Introductory Chemistry  Paul S. Szalay
In this guided-inquiry experiment, a two-component solid mixture of caffeine and ibuprofen is separated through a series of solution extractions and precipitations. The components are then analyzed using IR spectrophotometry to determine how effectively they were separated.
Szalay, Paul S. J. Chem. Educ. 2008, 85, 285.
Acids / Bases |
Drugs / Pharmaceuticals |
IR Spectroscopy |
Qualitative Analysis |
Separation Science |
Solutions / Solvents
Receptor Surface Models in the Classroom: Introducing Molecular Modeling to Students in a 3-D World  Werner J. Geldenhuys, Michael Hayes, Cornelis J. Van der Schyf, David D. Allen, and Sarel F. Malan
Proposes a novel method for teaching drug interactions with a receptor, enzyme, or any other macromolecule or protein using plastic molecular models and aluminum foil.
Geldenhuys, Werner J.; Hayes, Michael; Van der Schyf, Cornelis J.; Allen, David D.; Malan, Sarel F. J. Chem. Educ. 2007, 84, 979.
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Laboratory Computing / Interfacing |
Medicinal Chemistry |
Molecular Modeling |
Enzymes
Nature's Way To Make the Lantibiotics  Heather A. Relyea and Wilfred A. van der Donk
This article focuses on one class of antimicrobial compounds, the lantibiotics, and discusses their biosynthetic pathways as well as their molecular mode of action. In the course of the review, the meaning of the terms regio-, chemo-, and stereoselectivity are discussed.
Relyea, Heather A.; van der Donk, Wilfred A. J. Chem. Educ. 2006, 83, 1769.
Applications of Chemistry |
Bioorganic Chemistry |
Biotechnology |
Biosynthesis |
Catalysis |
Drugs / Pharmaceuticals |
Proteins / Peptides
An Introduction to UV–Vis Spectroscopy Using Sunscreens  Harriet P. Moeur, Andrew Zanella, and Thomas Poon
Two commercially available lotions that utilize only one active ingredient as a sunscreen were used to develop a general chemistry laboratory experiment involving the quantitative determination of the active component in each lotion by UVvis spectroscopy.
Moeur, Harriet P.; Zanella, Andrew; Poon, Thomas. J. Chem. Educ. 2006, 83, 769.
Drugs / Pharmaceuticals |
Fluorescence Spectroscopy |
Spectroscopy |
UV-Vis Spectroscopy
The Discovery and Development of Cisplatin  Rebecca A. Alderden, Matthew D. Hall, and Trevor W. Hambley
Cisplatin is currently one of the most widely used anticancer drugs in the world. The unlikely events surrounding the discovery of its anticancer activity, subsequent introduction into the clinic, and the continuing research into platinum compounds is the subject of this review.
Alderden, Rebecca A.; Hall, Matthew D.; Hambley, Trevor W. J. Chem. Educ. 2006, 83, 728.
Bioinorganic Chemistry |
Coordination Compounds |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Metallic Bonding |
Oxidation State |
Synthesis
Presumptive and Confirmatory Drug Tests  Craig Anderson
Tests for illegal drugs were performed on unknowns obtained from over-the-counter cold medicines. Substances that tested positive for the qualitative Marquis color test were found to be false positives for illegal substances, while scopolamine hydrochloride shows a false positive for cocaine hydrochloride with the cobalt thiocyanate reagent.
Anderson, Craig. J. Chem. Educ. 2005, 82, 1809.
Drugs / Pharmaceuticals |
Qualitative Analysis |
Acids / Bases |
Gas Chromatography |
IR Spectroscopy |
Mass Spectrometry
Exploration of the Chemistry of Plants: A General Education Course  Margareta Séquin
Plant-related topics, from carbon dating and soil chemistry to plant colors, odors, and poisons, are used to introduce and illustrate increasingly complex chemistry topics. Additional sections on plant-derived foods, dyes, and medicines stress human dependence on plant compounds.
Séquin, Margareta. J. Chem. Educ. 2005, 82, 1787.
Drugs / Pharmaceuticals |
Dyes / Pigments |
Natural Products |
Nonmajor Courses |
Plant Chemistry
Stoichiometry of Calcium Medicines  Gabriel Pinto
Calcium supplements provide an excellent context in which to review most of the core content of general chemistry, namely, stoichiometry, concentration units, hydration of salts, inorganic and organic salts, physiological importance of elements, resonance in ions, geometry of polyatomic ions, and isomerism.
Pinto, Gabriel. J. Chem. Educ. 2005, 82, 1509.
Stoichiometry |
Applications of Chemistry |
Drugs / Pharmaceuticals |
Medicinal Chemistry
Based on a True Story: Using Movies as Source Material for General Chemistry Reports  Mark A. Griep and Marjorie L. Mikasen
Presents a list of one dozen, highly rated movies in which the focus is either a scientist's chemical research or the societal impact of some chemical compound. The method by which two of these movies were used as source material for a written report in a general chemistry course is described.
Griep, Mark A.; Mikasen, Marjorie L. J. Chem. Educ. 2005, 82, 1501.
Medicinal Chemistry |
Women in Chemistry |
Applications of Chemistry |
Drugs / Pharmaceuticals |
Industrial Chemistry |
Nonmajor Courses |
Nuclear / Radiochemistry
A Supramolecular Approach to Medicinal Chemistry: Medicine Beyond the Molecule  David K. Smith
This article emphasizes a conceptual view of medicinal chemistry, which has important implications for the future, as the supramolecular approach to medicinal-chemistry products outlined here is rapidly allowing nanotechnology to converge with medicine. In particular, this article discusses recent developments including the rational design of drugs such as Relenza and Tamiflu, the mode of action of vancomycin, and the mechanism by which bacteria develop resistance, drug delivery using cyclodextrins, and the importance of supramolecular chemistry in understanding protein aggregation diseases such as Alzheimer's and CreutzfieldJacob.
Smith, David K. J. Chem. Educ. 2005, 82, 393.
Drugs / Pharmaceuticals |
Noncovalent Interactions |
Medicinal Chemistry |
Nanotechnology |
Proteins / Peptides
Using Clinical Cases To Teach General Chemistry  Brahmadeo Dewprashad, Charles Kosky, Geraldine S. Vaz, and Charlotte L. Martin
This article describes how a fact-based clinical case was effectively used to motivate and enrich the classroom experience and review many of the concepts covered in general chemistry. The case involves an elderly patient who was brought to the emergency room. The results of his physical examination and laboratory analysis of his blood are presented. The students, in peer-led groups, work through the chemical principles involved in the doctor's diagnosis and treatment options for the patient. The article describes the case study, instructors' observations, and students' perception of the activity.
Dewprashad, Brahmadeo; Kosky, Charles; Vaz, Geraldine S.; Martin, Charlotte L. J. Chem. Educ. 2004, 81, 1471.
Acids / Bases |
Drugs / Pharmaceuticals |
Equilibrium |
Kinetics |
Medicinal Chemistry
The Strange Case of Mole Airlines Flight 1023  Karl F. Jones
Forensic chemistry mystery / puzzle involving determining formulas based on chemical compositions.
Jones, Karl F. J. Chem. Educ. 2003, 80, 407.
Drugs / Pharmaceuticals |
Stoichiometry |
Molecular Properties / Structure |
Enrichment / Review Materials |
Applications of Chemistry |
Forensic Chemistry
A General Chemistry Laboratory Theme: Spectroscopic Analysis of Aspirin  Houston Byrd and Stephen E. O’Donnell
A laboratory sequence designed for introductory chemistry students that focusses on the synthesis and spectroscopic (IR and NMR) and chromatographic (HPLC) analysis of aspirin as an alternative to traditional general chemistry laboratories.
Byrd, Houston; O’Donnell, Stephen E. J. Chem. Educ. 2003, 80, 174.
Drugs / Pharmaceuticals |
Chromatography |
NMR Spectroscopy |
UV-Vis Spectroscopy |
Aromatic Compounds |
Atomic Spectroscopy |
Instrumental Methods
Molecules, Miracles and Medicine
   by Andrew Lasslo  Peggy Geiger
Brief histories of morphine, procaine, aspirin, barbital, sulfanilamide, penicillin, valium, and cortisone.
Geiger, Peggy. J. Chem. Educ. 2002, 79, 805.
Drugs / Pharmaceuticals |
Medicinal Chemistry
Drugs and the Human Body: With Implications for Society, 6th Edition
   by Ken Liska   David J. A. Schedler
Facts about drug sources, history, action in the body, side effects, interactions, tolerance, abuse potential, dosage, dependency, delivery systems, and alternatives to drug use.
Schedler, David J. A. J. Chem. Educ. 2002, 79, 805.
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Applications of Chemistry
Modeling the Drug Discovery Process: The Isolation and Biological Testing of Eugenol from Clove Oil  William H. Miles and Patricia M. Smiley
Experiment that illustrates the principles of modern drug discovery.
Miles, William H.; Smiley, Patricia M. J. Chem. Educ. 2002, 79, 90.
Acids / Bases |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Natural Products |
Separation Science |
Applications of Chemistry
A Modification of a Lactase Experiment by Use of Commercial Test Strips  Tammy J. Melton
Using urinalysis test strips to detect the presence of glucose.
Melton, Tammy J. J. Chem. Educ. 2001, 78, 1243.
Carbohydrates |
Catalysis |
Drugs / Pharmaceuticals |
Enzymes |
Nonmajor Courses |
Qualitative Analysis |
Laboratory Equipment / Apparatus
Combinatorial Synthesis and Discovery of an Antibiotic Compound. An Experiment Suitable for High School and Undergraduate Laboratories  Scott E. Wolkenberg and Andrew I. Su
An experiment designed to introduce students to combinatorial chemistry as applied to drug discovery.
Wolkenberg, Scott E.; Su, Andrew I. J. Chem. Educ. 2001, 78, 784.
Aqueous Solution Chemistry |
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Synthesis |
Combinatorial Chemistry |
Applications of Chemistry
Two Faces of Alkaloids  Jirí Dostál
The article discusses and compares the salts and free bases of six well-known alkaloids: nicotine, morphine, cocaine, sanguinarine, allocryptopine, and magnoflorine. Relevance for the biological and medical uses of these compounds is emphasized.
Dostál, Jirí. J. Chem. Educ. 2000, 77, 993.
Acids / Bases |
Bioorganic Chemistry |
Drugs / Pharmaceuticals |
Natural Products |
Aromatic Compounds |
Medicinal Chemistry
Identification of Pharmaceuticals via Computer-Aided Thin Layer Chromatography  Anthony J. Macherone Jr. and Theodore J. Siek
This analytical laboratory experiment demonstrates the methodology of TLC in its relation to toxicology and forensic chemistry. It is easily adapted for high school seniors or undergraduates and employs experimental techniques associated with TLC and post-lab data analysis with concomitant introduction of concepts.
Macherone, Anthony J., Jr.; Siek, Theodore J. J. Chem. Educ. 2000, 77, 366.
Forensic Chemistry |
Drugs / Pharmaceuticals |
Toxicology |
Thin Layer Chromatography |
Separation Science
Synthesis of the Sweetener Dulcin from the Analgesic Tylenol  Brian D. Williams, Birute Williams, and Louise Rodino
A sequence suitable for the synthesis of the sweetener dulcin from the analgesic acetaminophen. The analgesic phenacetin is isolated during the synthesis as an intermediate and consequently the experiment can be adopted as a multistep synthesis or as either of two single-period transformations.
Williams, Brian D.; Williams, Birute; Rodino, Louise. J. Chem. Educ. 2000, 77, 357.
Synthesis |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Aromatic Compounds
Microwave Irradiation Reactions: Synthesis of Analgesic Drugs  Gholam A. Mirafzal and Jolene M Summer
Over-the-counter analgesics such as aspirin, acetanilide, phenacetin, and acetaminophen are conveniently prepared in a microwave at 30% power for five minutes. Recrystallization from appropriate solvents results in solid products in good to excellent yields.
Mirafzal, Gholam A.; Summer, Jolene M. J. Chem. Educ. 2000, 77, 356.
Drugs / Pharmaceuticals |
Synthesis |
Medicinal Chemistry |
Aromatic Compounds |
Amines / Ammonium Compounds |
Esters
Experiments with Aspirin  Londa L. Borer and Edward Barry
Experiments include (i) synthesis, purification, and characterization of aspirin by mp and TLC, (ii) percentage composition of a commercial aspirin tablet by titration, (iii) kinetics of the hydrolysis of aspirin to salicylic acid under various conditions, (iv) synthesis and characterization of copper(II) aspirinate and copper(II) salicylate, and (v) reaction of copper(II) aspirinate in aqueous solution.
Borer, Londa L.; Barry, Edward. J. Chem. Educ. 2000, 77, 354.
Synthesis |
Kinetics |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Aromatic Compounds
A Brine Shrimp Bioassay for Measuring Toxicity and Remediation of Chemicals  Marya Lieberman
A bioassay using brine shrimp was adapted to measure the toxicity of household chemicals. One project is described in which students collect dose-response curves for seven commercial flea-killing products. Next, groups of students researched the insecticidal ingredients of the flea products. On the basis of the structures of the active ingredients, they chose remediation methods to make the flea product less toxic to brine shrimp; procedures included copper-catalyzed hydrolysis, adsorption onto activated charcoal, bleach treatment, and photodegradation.
Lieberman, Marya. J. Chem. Educ. 1999, 76, 1689.
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Nonmajor Courses |
Toxicology
An Acid-Base Chemistry Example: Conversion of Nicotine  John H. Summerfield
The current government interest in nicotine conversion by cigarette companies provides an example of acid-base chemistry that can be explained to students in the second semester of general chemistry.
Summerfield, John H. J. Chem. Educ. 1999, 76, 1397.
Acids / Bases |
Drugs / Pharmaceuticals |
Equilibrium
Exploring the Ocean- Stating the Case for Chemistry  Paul J. Scheuer
Salinity measurements and carbonate-bicarbonate equilibria used to be the only topics studied under what was known as "marine chemistry". But in the past few decades organic chemists have changed this situation profoundly by exploring the diverse fauna and flora of coral reefs and the ocean floor.
Scheuer, Paul J. J. Chem. Educ. 1999, 76, 1075.
Natural Products |
Drugs / Pharmaceuticals |
Applications of Chemistry
Production, Extraction, and Qualitative Testing of Penicillin: A Biochemistry Experiment for Health Science Chemistry Courses   Richard E. Stevens and Kara C. Billingsley
This laboratory procedure guides students through the growth of a submerged Penicillium chrysogenum culture. Subsequent steps include extraction of the penicillin by adsorption onto activated charcoal, extraction with acetone, and qualitative testing of the drug on a bacterial culture. The laboratory procedure is designed for freshman-level health science chemistry courses.
Stevens, Richard E.; Billingsley, Kara C. J. Chem. Educ. 1998, 75, 1264.
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Nonmajor Courses
Synthesis of Aspirin: A General Chemistry Experiment  John A. Olmsted III
An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. It is the two-step synthesis of aspirin starting from oil of wintergreen. The mechanism for this synthesis provides examples of three major classes of chemical reactions: hydrolysis, condensation, and proton transfer.
Olmsted, John A., III. J. Chem. Educ. 1998, 75, 1261.
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Mechanisms of Reactions |
Aromatic Compounds |
Carboxylic Acids |
Aldehydes / Ketones
The Art and Science of Organic and Natural Products Synthesis  K. C. Nicolaou, E. J. Sorensen, and N. Winssinger
In this article, the history of the art and science of organic and natural products synthesis is briefly reviewed and the state of the art is discussed. The impact of this discipline on biology and medicine is amply demonstrated with examples, and projections for future developments in the field are made.
Nicolaou, K. C.; Sorensen, E. J.; Winssinger, N. J. Chem. Educ. 1998, 75, 1225.
Natural Products |
Synthesis |
Medicinal Chemistry |
Applications of Chemistry |
Drugs / Pharmaceuticals
An Efficient Microscale Procedure for the Synthesis of Aspirin  Sangeeta Pandita and Samta Goyal
We have found that aspirin can be synthesized on microscale by a simple and efficient procedure that eliminates the heating step employed in literature procedures and gives a pure, ferric-negative product (no purple color with alcoholic ferric chloride solution).
Pandita, Sangeeta; Goyal, Samta. J. Chem. Educ. 1998, 75, 770.
Microscale Lab |
Synthesis |
Drugs / Pharmaceuticals
A Study of the pH of Sweat for Horses: A Student-Devised Study by Science and Health Science Majors  John Tierney, Lori Peacock, Erica Sorkin, and Susan Ware
This article describes the results obtained when the pH for horse sweat was measured. Comparisons with the studies on humans are also noted. The pH of perspiration produced by mares and gelding was measured under controlled conditions and found to be between 6.7 to 10.
Tierney, John; Peacock, Lori; Sorkin, Erica; Ware, Susan. J. Chem. Educ. 1997, 74, 1135.
Learning Theories |
Acids / Bases |
Drugs / Pharmaceuticals |
Undergraduate Research
The Thermodynamics of Drunk Driving  Robert Q. Thompson
Biological, chemical, and instrumental variables are described along with their contributions to the overall uncertainty in the value of BrAC/BAC.
Thompson, Robert Q. J. Chem. Educ. 1997, 74, 532.
Thermodynamics |
Nonmajor Courses |
Forensic Chemistry |
Drugs / Pharmaceuticals |
Applications of Chemistry
Reports from Other Journals: Gleanings from Scientific American  Paul F. Schatz
Scientific American provides a rich resource of background and general interest material for topics of chemical interest that can be used to supplement and enhance chemistry lecture and laboratory courses.
Schatz, Paul F. J. Chem. Educ. 1996, 73, A234.
Drugs / Pharmaceuticals |
Nuclear / Radiochemistry |
Calorimetry / Thermochemistry |
Laboratory Equipment / Apparatus |
Applications of Chemistry |
Consumer Chemistry |
Laboratory Management
A Simulated Growth Hormone Analysis  Mary Harris
Growth hormone is a drug that is sometimes abused by amateur or professional athletes for performance-enhancement. This laboratory is a semi-microscale simulation analysis of a sample of "urine" to detect proteins of two very different molecular weights.
Harris, Mary. J. Chem. Educ. 1996, 73, 735.
Hormones |
Proteins / Peptides |
Separation Science |
Microscale Lab |
Drugs / Pharmaceuticals |
Qualitative Analysis
The Analysis of a Drug Circular as a First-Day Assignment for Freshman Chemistry: A Jump Start for the Semester  Anthony J. Millevolte
Introductory assignment to demonstrate the importance and interdisciplinary nature of chemistry; students are asked to answer questions from a drug circular.
Millevolte, Anthony J. J. Chem. Educ. 1995, 72, 1085.
Drugs / Pharmaceuticals |
Enrichment / Review Materials |
Applications of Chemistry
What Do College Students Know About Illegal Drugs?  Christine K. F. Hermann
Survey of student understanding of illegal drugs.
Hermann, Christine K. F. J. Chem. Educ. 1995, 72, 925.
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Enrichment / Review Materials
Determination of Calcium in Analgesic Tablets Using Atomic Absorption Spectrophotometry  Quigley, Michael N.
Procedure to determine the amount of calcium in calcium carbonate coated analgesic tablets using an atomic absorption spectrophotometer.
Quigley, Michael N. J. Chem. Educ. 1994, 71, 800.
Quantitative Analysis |
Atomic Spectroscopy |
Drugs / Pharmaceuticals
Rating antacids in Consumer Reports  Martin, Geoffrey
This article presents a Consumer Reports study on antacid effectiveness via titration.
Martin, Geoffrey J. Chem. Educ. 1988, 65, 214.
Acids / Bases |
Titration / Volumetric Analysis |
Consumer Chemistry |
Drugs / Pharmaceuticals |
Food Science
Consumer applications of chemical principles: Drugs  Hill, John W.; Jones, Susan M.
Acid-base chemistry of drugs (nicotine, cocaine, and aspirin), general anesthesia (nitrous oxide, enflurane, isoflurane, halothane), local anesthetics (procaine, lidocaine, cocaine), and intravenous anesthetics (thiopental, ketamine hydrochloride, phencyclidine).
Hill, John W.; Jones, Susan M. J. Chem. Educ. 1985, 62, 328.
Consumer Chemistry |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Acids / Bases |
Applications of Chemistry
Drug stabilization against oxidative degradation  Akers, Michael J.
Describes the process of oxidation and ways in which pharmaceutical preparations can be protected from oxidative degredation.
Akers, Michael J. J. Chem. Educ. 1985, 62, 325.
Drugs / Pharmaceuticals |
Oxidation / Reduction |
Medicinal Chemistry |
Nonmajor Courses
Separation and identification of commonly used drugs: A thin-layer chromatography experiment for freshman chemistry  Bonicamp, Judith M.
Using a simplified and accelerated TLC kit for drug detection.
Bonicamp, Judith M. J. Chem. Educ. 1985, 62, 160.
Separation Science |
Thin Layer Chromatography |
Drugs / Pharmaceuticals
Understanding drugs: A new interdisciplinary course  Evans, Mildred H.
Course outline, source materials, and film list for a layman's interdisciplinary course.
Evans, Mildred H. J. Chem. Educ. 1984, 61, 671.
Drugs / Pharmaceuticals |
Nonmajor Courses
The role of the humanities in the teaching of chemistry  Labianca, Dominick A.
Integrating chemistry with the humanities to make it meaningful for nonmajors.
Labianca, Dominick A. J. Chem. Educ. 1984, 61, 148.
Drugs / Pharmaceuticals |
Nonmajor Courses |
Applications of Chemistry
The chemical oceanographer   Abel, Robert B.
Oceanography holds fascinating subject matter for students learning chemistry.
Abel, Robert B. J. Chem. Educ. 1983, 60, 221.
Water / Water Chemistry |
Food Science |
Geochemistry |
Atmospheric Chemistry |
Drugs / Pharmaceuticals |
Applications of Chemistry
Chemistry and detective fiction: An interdisciplinary program for the nonscience major  Labianca, Dominick A.; Reeves, William J.
Drugs, poisons, and detective fiction offer many possibilities for science/literature integration. The interdisciplinary teaching methods described in this note can address the problem of the alienation harbored by many non-majors toward science and can certainly contribute to a reversal of negative attitudes and to an increased interest in science beyond the formal classroom setting.
Labianca, Dominick A.; Reeves, William J. J. Chem. Educ. 1981, 58, 683.
Nonmajor Courses |
Forensic Chemistry |
Drugs / Pharmaceuticals |
Toxicology
A non-traditional science laboratory for the nonscience major: An interdisciplinary experience in the reality of science  Dominick, A. Labianca
A non-traditional science laboratory for the nonscience major whose foci are environmental pollution, pharmacology, and toxicology.
Dominick, A. Labianca J. Chem. Educ. 1980, 57, 198.
Nonmajor Courses |
Drugs / Pharmaceuticals |
Toxicology
Drugs in the chemistry laboratory: The conversion of acetaminophen into phenacetin  Volker, Eugene J.; Pride, Ernest; Hough, Charles
The phenolic alcohol group of acetaminophen is alkylated with ethyl iodide using the basic catalyst K2CO3.
Volker, Eugene J.; Pride, Ernest; Hough, Charles J. Chem. Educ. 1979, 56, 831.
Nonmajor Courses |
Applications of Chemistry |
Medicinal Chemistry |
Drugs / Pharmaceuticals |
Synthesis |
Catalysis |
Phenols |
Alcohols
Some biochemistry of sedatives  J. Chem. Educ. Staff
Antianxiety agents / sleep reducers, the discovery of sedatives and their chemistry, and biological responses to sedatives.
J. Chem. Educ. Staff J. Chem. Educ. 1979, 56, 402.
Drugs / Pharmaceuticals |
Applications of Chemistry |
Medicinal Chemistry
Medicinal chemistry of aspirin and related drugs  J. Chem. Educ. Staff
Nonprescription analgesics, the discovery of aspirin, pain and analgesic activity, inflammation and the role of chemical agents, fever and its reduction, aspirin in stroke prevention, and toxicity and side effects.
J. Chem. Educ. Staff J. Chem. Educ. 1979, 56, 331.
Applications of Chemistry |
Medicinal Chemistry |
Drugs / Pharmaceuticals |
Toxicology
Pharmacological projects/case studies for teaching molecular structure and reactivity  Webb, John; Rasmussen, Malcolm
Using pharmacological agents to provide projects that develop and illustrate concepts of molecular stereochemistry, functional groups, and types of reactions and reactivity.
Webb, John; Rasmussen, Malcolm J. Chem. Educ. 1977, 54, 677.
Drugs / Pharmaceuticals |
Stereochemistry |
Reactions |
Mechanisms of Reactions
Emphasis on acids and bases  J. Chem. Educ. Staff
Considers the acidity or basicity in soils and natural waters; the acid-base balance in body chemistry; acidic and basic foods; the approximate pH values of common fluids; examples of acidic, basic, and neutral drugs; and the commercial preparation of nitric acid.
J. Chem. Educ. Staff J. Chem. Educ. 1977, 54, 626.
Acids / Bases |
Water / Water Chemistry |
Food Science |
Applications of Chemistry |
pH |
Drugs / Pharmaceuticals
Copper(II) aspirinate project for the general chemistry laboratory  Dudek, Emily
The weight percent of copper in student-prepared copper(II) aspirinate is measured by electrogravimetric, spectrophotometric, and titrimetric methods.
Dudek, Emily J. Chem. Educ. 1977, 54, 329.
Titration / Volumetric Analysis |
Medicinal Chemistry |
Drugs / Pharmaceuticals |
Synthesis |
Quantitative Analysis
The effects of HCl and aspirin on the stomach: An equilibrium review  DeLorenzo, Ronald
The chemical effect and medical implications of taking aspirin.
DeLorenzo, Ronald J. Chem. Educ. 1977, 54, 306.
Equilibrium |
Acids / Bases |
pH |
Drugs / Pharmaceuticals |
Medicinal Chemistry |
Applications of Chemistry
Questions [and] Answers  Campbell, J. A.
284-289. Six questions and their answers on practical applications of chemistry.
Campbell, J. A. J. Chem. Educ. 1977, 54, 161.
Medicinal Chemistry |
Enzymes |
Nuclear / Radiochemistry |
Drugs / Pharmaceuticals |
Applications of Chemistry |
Enrichment / Review Materials
Separation of an APC mixture. A quantitative analysis experiment  Haddad, Paul; Rasmussen, Malcolm
In this paper the well known technique of pH, controlled extractive separation of a mixture of an acidic, basic, and neutral organic substance has been applied to separation and analysis of a mixture of the drugs aspirin, caffeine, and phenacetin.
Haddad, Paul; Rasmussen, Malcolm J. Chem. Educ. 1976, 53, 731.
Drugs / Pharmaceuticals |
pH |
Acids / Bases |
Separation Science
Physicochemical properties of antacids  Hem, Stanley L.
An experiment to demonstrate the acid neutralizing reaction of sodium carbonate, calcium carbonate, and aluminum hydroxide gel.
Hem, Stanley L. J. Chem. Educ. 1975, 52, 383.
Acids / Bases |
Consumer Chemistry |
Drugs / Pharmaceuticals
Collecting labels for household products: A project for students in chemistry courses for nonscience majors  Melford, Sara Steck
A project that requires students to consider some of the many chemicals that they use and come into contact with on an almost daily basis.
Melford, Sara Steck J. Chem. Educ. 1975, 52, 381.
Nonmajor Courses |
Consumer Chemistry |
Applications of Chemistry |
Drugs / Pharmaceuticals |
Food Science
A new chemistry program for nursing and allied health students  Stanitski, Conrad L.; Sears, Curtis T., Jr.
Outlines and discusses the topics considered in a chemistry program for nursing and allied health students.
Stanitski, Conrad L.; Sears, Curtis T., Jr. J. Chem. Educ. 1975, 52, 226.
Nonmajor Courses |
Applications of Chemistry |
Medicinal Chemistry |
Oxidation / Reduction |
Catalysis |
Acids / Bases |
pH |
Metabolism |
Drugs / Pharmaceuticals
An interdisciplinary approach to science and literature  Labianca, Dominick A.; Reeves, William J.
Describes a literature course that concentrates on readings concerned with certain aspects of drug use and a science course that analyzes the problems associated with such drug intake.
Labianca, Dominick A.; Reeves, William J. J. Chem. Educ. 1975, 52, 66.
Drugs / Pharmaceuticals
TLC detection of caffeine in commercial products  Pavlik, James W.
An introductory experiment that involves the thin layer chromatography detection of caffeine in a variety of familiar pharmaceutical products.
Pavlik, James W. J. Chem. Educ. 1973, 50, 134.
Thin Layer Chromatography |
Chromatography |
Separation Science |
Consumer Chemistry |
Drugs / Pharmaceuticals |
Qualitative Analysis
The thin-layer chromatography of drugs. A laboratory experiment  Neman, R. L.
Students are introduced to thin layer chromatography, are provided samples known to contain alkaloids and barbiturates, separate the mixtures using tlc, determine the components of their unknowns, and calculate Rf values for the components.
Neman, R. L. J. Chem. Educ. 1972, 49, 834.
Chromatography |
Thin Layer Chromatography |
Separation Science |
Drugs / Pharmaceuticals
A pharmaceutical analysis experiment for general chemistry laboratory  Baine, Ogden; Hicks, Sterling
This experiment involves qualitative and quantitative determinations of the active acidic components in tablets of aspirin, para-aminosalicylic acid, ascorbic acid, quinidine sulfate, thiamine hydrochloride, phenobarbital, and sulfathiazole.
Baine, Ogden; Hicks, Sterling J. Chem. Educ. 1959, 36, 388.
Qualitative Analysis |
Drugs / Pharmaceuticals